A5004872562- Veterinary Equine Medical Research
- Obstructive Sleep Apnea Research
- Streptococcal Infections and Treatments
- Sports, Gender, and Society
- Telemedicine and Telehealth Implementation
- Enhanced Recovery After Surgery
- Retirement, Disability, and Employment
- Education Systems and Policy
- Antibiotic Resistance in Bacteria
- Veterinary Practice and Education Studies
- Asthma and respiratory diseases
- Cardiovascular Effects of Exercise
- Pain Mechanisms and Treatments
- Legionella and Acanthamoeba research
- Military history and social perspectives
- Automotive and Human Injury Biomechanics
- Multiple Myeloma Research and Treatments
- Sleep and Work-Related Fatigue
- Hypothalamic control of reproductive hormones
- Infant Health and Development
- Pharmacology and Obesity Treatment
- Primary Care and Health Outcomes
- Vibrio bacteria research studies
- Legume Nitrogen Fixing Symbiosis
- Veterinary medicine and infectious diseases
Guy's and St Thomas' NHS Foundation Trust
2016-2023
St Thomas' Hospital
2022-2023
Baylor University
2022
The Royal Free Hospital
2017
University College London
2017
University of Surrey
2015
University of Liverpool
2008-2012
University of Manchester
2012
Leverhulme Trust
2009
Royal Veterinary College
2008
S ummary . When isoniazid and pyridoxal are mixed in equimolar quantities a hydrazone is formed which able to complex with iron. The oral administration of this compound rats single doses 25–100 mg/kg leads an increase faecal iron excretion up 8 times the normal level. In tissue culture remove from Chang cells. results suggest that may be potential value for therapy overload.
The aim of this study was to compare the effects aspirin on platelet function as measured by 'classical' template bleeding time with a new ex vivo method measuring closure times using PFA-100 machine. Platelet aggregation in response arachidonic acid also vivo.The trial randomized, double-blind, placebo-controlled crossover design, each volunteer taking 750 mg (BP) or placebo, three day for 5 days, an 18 wash-out period between treatments. Bleeding and were before first dose 0.5 h after last...
BACKGROUND--The cysteinyl leukotrienes may play a central part in the mechanisms of aspirin-sensitive asthma. Previous work has shown that individuals with asthma have high basal urinary LTE4 levels which increase further upon aspirin ingestion, and sulphidopeptide leukotriene receptor antagonists attenuate aspirin-induced airflow obstruction. If cause asthmatic reactions, inhibition 5-lipoxygenase pathway should prevent bronchospasm. This hypothesis been tested ZD2138, specific non-redox...
Abstract The current study aims to make welfare-based recommendations for gun/cartridge combinations and shooting positions that will ensure death of the sheep (horned, unhorned, rams ewes), without need either sticking or pithing. examined pathophysiology captive-bolt gun (CBG) injuries result in incomplete concussion leading death. Behavioural, brainstem cranial/spinal responses were along with gross pathology 489 animals (116 polled ewes, 134 horned 117 122 rams) following a variety...
Summary Reasons for performing study: Idiopathic headshaking is often a facial pain syndrome, but diagnostic protocol has not been described. In previous study, caudal compression of the infraorbital nerve treatment offered fair success rate, low case numbers and short follow‐up time were limitations. Objectives: To describe headshaking, examining role bilateral local analgesia posterior ethmoidal (PET block). report longer‐term after surgery original cases further to determine whether...
An assessment of mental impairment and behavioral disabilities in 289 residents six old people9s homes indicated that 50.6% were probably demented 54% needed considerable help daily living, 74% taking prescribed medication, 11% four or more drugs. There was a wide variation between those rated as behaviourally disabled, the amount medication prescribed. A follow-up 60 mentally impaired showed few remediable psychiatric disorders psychotoxic drug effects. community nurse working with...
Summary Reasons for designing and reporting technique : Idiopathic headshaking has remarkable similarities to human neuropathic facial pain syndromes associated with post herpetic trigeminal neuralgia. These derive from abnormal sensory function within the peripheral or central pathways of nerve (TgN). Limiting input TgN can be helpful in controlling perception pain. Rhizotomy infraorbital branch as it emerges canal been reported but a poor efficacy. A novel involves compression at more...
BACKGROUND--Leukotrienes are lipid mediators generated from arachidonic acid by the 5-lipoxygenase pathway which may play an important part in pathophysiology of asthma. Previous studies have demonstrated attenuation allergen-induced early and late asthmatic responses leukotriene receptor antagonists. The effect inhibitor ZD2138, a non-redox lipoxygenase inhibits synthesis for 24 hours after single doses 350 mg, on has been assessed. METHODS--Eight subjects with baseline FEV1 > 70% were...
Background. Antimicrobial resistance is an emerging global health issue. Data on the epidemiology of multidrug-resistant organisms are scarce for Africa, especially in HIV-infected individuals who often have frequent contact with healthcare. We investigated prevalence extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) carriage stool among children attending HIV outpatient department Harare, Zimbabwe. Methods. recruited were stable antiretroviral therapy (ART) a clinic...
Iron chelation therapy for patients maintained on a regular transfusion regime is at present best carried out by means of daily infusions desferrioxamine (Hussain et al 1977; Pippard 1978) but this onerous the patient and has social economic disadvantages. Many recent attempts to provide more effective drugs iron have been summarized Jacobs (1979) increasing attention now being paid possibility oral therapy. Hoy showed that when isonicotinic acid hydrazide (INH) pyridoxal are mixed in...
The major extracellular enzyme of Legionella pneumophila, a metalloprotease, has been proposed as pathogenic factor in Legionnaires' disease due to its cytotoxic, tissue-destructive, and phagocyte-inhibitory properties. relevance these activities depends on the production protease during infection, i.e. by L. pneumophila multiplying intracellularly. In this study, was demonstrated produce guinea-pig human alveolar macrophages infected vitro. After 24 h approximately 0.1 0.2 micrograms per...
Summary The intestine of neonatal mammals must be able to secrete lactase enzyme hydrolyse lactose in its mother's milk. Failure results failure digest lactose. This osmotic diarrhoea, weight loss, thrive, lethargy, colic and abdominal distension. Lactose intolerance may occur secondarily intestinal bacterial infection. Primary is recognised human infants. Here we report 2 cases suspected primary foals. foals responded well oral administration exogenous enzyme.
Summary This project investigated the clinical value of a human whole blood point‐of‐care (POC) triglyceride (TG) measurement device to determine equid TG concentrations. Equid plasma measurements were determined in commercial laboratory and also using on POC from patients with concentrations within normal range severely hypertriglyceridaemic. Results compared between methods Bland‐Altman method for validation. Seventy‐four samples collected: 35 inappetent or starved (considered ‘at‐risk’...
Unilateral lymphadenopathy of the groin is commonly seen in general practice. We report on a patient with initial features suggestive sarcoidosis, but who, after careful history taking and further investigation, had cat scratch disease. A 29 year old woman visited her practitioner painless swelling right groin. She was referred to surgeon, who aspirated node. The aspirate contained blood range lymphoid cells, suggesting reactive lymph Ultrasonography confirmed numerous large nodes...
Adele Williams and colleagues argue that assumptions made by some regarding remote prescribing from telemedicine providers are incorrect, such services can help to improve animal health welfare reduce the burden on physical veterinary practices.