A5033422681- Urinary Tract Infections Management
- Gut microbiota and health
- Escherichia coli research studies
- Clostridium difficile and Clostridium perfringens research
- Infections and bacterial resistance
- Pediatric Urology and Nephrology Studies
- Microbial Applications in Construction Materials
- Biomedical Research and Pathophysiology
- Cancer Research and Treatments
- Microbial Community Ecology and Physiology
- Enzyme Production and Characterization
- Biochemical and Molecular Research
- Bacterial Identification and Susceptibility Testing
- Advanced Glycation End Products research
- Helicobacter pylori-related gastroenterology studies
- Bladder and Urothelial Cancer Treatments
- Antibiotic Resistance in Bacteria
- Enzyme Structure and Function
- Gastrointestinal motility and disorders
University of Michigan
2019-2024
Vanderbilt University
2017-2019
Vanderbilt University Medical Center
2019
Nashville Oncology Associates
2018
One of the most common urologic problems afflicting millions people worldwide is urinary tract infection (UTI). The severity UTIs ranges from asymptomatic bacteriuria to acute cystitis, and in severe cases, pyelonephritis urosepsis. primary cause uropathogenic Escherichia coli (UPEC), for which current antibiotic therapies often fail. UPEC forms multicellular communities known as biofilms on catheters, well within bladder epithelial cells. Biofilm formation protects environmental conditions,...
Biofilms are multicellular bacterial communities encased in a self-secreted extracellular matrix comprised of polysaccharides, proteinaceous fibers, and DNA. Organization these components lends spatial organization the biofilm community. Here we demonstrate that oxygen gradients uropathogenic Escherichia coli (UPEC) biofilms lead to spatially distinct expression programs for quinol oxidases—components terminal electron transport chain. Our studies reveal cytochrome bd -expressing...
ABSTRACT A hallmark of Proteus mirabilis infection the urinary tract is formation stones. The ability to induce stone requires urease, a nickel metalloenzyme that hydrolyzes urea. This reaction produces ammonia as byproduct, which can serve nitrogen source and weak base raises local pH. resulting alkalinity induces precipitation ions form Transcriptional regulator UreR activates expression urease genes in urea-dependent manner. Thus, are highly expressed where urea abundant. Production...
This article provides a reusable dataset describing detailed phenotypic and associated clinical parameters in n=303 isolates of urinary
Antibiotics are the primary risk factor for Clostridioides difficile infections (CDIs), but other factors may also increase a person’s risk. In epidemiological studies, proton pump inhibitor (PPI) use has been associated with CDI incidence and recurrence. PPIs have alterations in human intestinal microbiota observational interventional studies. We evaluated effects of PPI omeprazole on structure murine its ability to disrupt colonization resistance C. . found treatment had minimal impact...
Catheter-associated urinary tract infections (CAUTIs) are a significant burden on healthcare systems, accounting for up to 40% of hospital-acquired globally. A prevalent CAUTI pathogen,
Abstract Biofilms are multicellular bacterial communities encased in a self-secreted extracellular matrix comprised of polysaccharides, proteinaceous fibers, and DNA. Organization these components lends spatial organization to the biofilm community such that residents can benefit from production common goods, while being protected exogenous insults. Spatial is driven by presence chemical gradients, as oxygen. Here we quantified localized expression two Escherichia coli cytochrome oxidases...
You have accessJournal of UrologyInfections/Inflammation/Cystic Disease the Genitourinary Tract: Kidney & Bladder II1 Apr 2018MP23-17 CYTOCHROME BD-I IS A POTENTIAL TARGET FOR ERADICATING UROPATHOGENIC E. COLI BIOFILMS Allison Eberly, Connor Beebout, John Brannon, Shuvro De, Madison Fitzgerald, Corrine Baroni, Douglass Clayton, and Maria Hadjifrangiskou EberlyAllison Eberly More articles by this author , BeeboutConnor Beebout BrannonJohn Brannon DeShuvro De FitzgeraldMadison Fitzgerald...
Abstract Proton pump inhibitor (PPI) use has been associated with microbiota alterations and susceptibility to Clostridioides difficile infections (CDIs) in humans. We assessed how PPI treatment alters the fecal whether promotes CDIs a mouse model. Mice receiving were gavaged 40 mg/kg of omeprazole during 7-day pretreatment phase, day C. challenge, following 9 days. found that mice treated not colonized by . When was combined single clindamycin treatment, one cage remained resistant...