A5077341972- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Advanced MRI Techniques and Applications
- Pharmacological Effects and Toxicity Studies
- Neurogenesis and neuroplasticity mechanisms
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Anesthesia and Neurotoxicity Research
- Face Recognition and Perception
- Genomics and Rare Diseases
- Autism Spectrum Disorder Research
- Glioma Diagnosis and Treatment
- Multisensory perception and integration
- Advanced Neuroimaging Techniques and Applications
- Neurobiology of Language and Bilingualism
- Memory and Neural Mechanisms
- Neuroscience and Neural Engineering
- Atomic and Subatomic Physics Research
- Renal and related cancers
- Color perception and design
- Neural and Behavioral Psychology Studies
- Nerve injury and regeneration
- Radiomics and Machine Learning in Medical Imaging
Capital Medical University
2019-2025
Objective By studying the surgical outcome of deep brain stimulation (DBS) different target nuclei for patients with refractory epilepsy, we aimed to explore a clinically feasible nucleus selection strategy. Methods We selected epilepsy who were not eligible resective surgery. For each patient, performed DBS on thalamic [anterior thalamus (ANT), subthalamic (STN), centromedian (CMN), or pulvinar (PN)] based location patient's epileptogenic zone (EZ) and possible epileptic network involved....
Emotion processing is an integral part of everyone's life. The basic neural circuits involved in emotion perception are becoming clear, though the emotion's cognitive remains under investigation. Utilizing stereo-electroencephalograph with high temporal-spatial resolution, this study aims to decipher pathway responsible for discriminating low-arousal and high-arousal emotions. This involves 19 patients pharmacologically resistant epilepsy who participate a delayed match/mismatch sample task...
Epilepsy is a chronic brain disease, which prone to relapse and affects individuals of all ages worldwide, particularly the very young elderly. Up one-third these patients are medically intractable require resection surgery. However, outcomes epilepsy surgery rely upon clear identification epileptogenic zone (EZ). The combination cortico-cortical evoked potential (CCEP) electrocorticography (ECoG) provides an opportunity observe connectivity human network more comprehensive information that...
Diagnostic challenges exist in the presurgical evaluation of patients with magnetic resonance imaging (MRI) negative cingulate epilepsy (CE) because heterogeneity clinical semiology and lack localizing findings on scalp electroencephalographic (EEG) recordings. We aimed to examine neuroimaging characteristics a consecutive cohort MRI-negative CE focus two image post-processing methods, including MRI morphometric analysis program (MAP) 18F-fluorodeoxyglucose-positron emission tomography-MRI...
Abstract Aims Focal cortical dysplasia (FCD) is a major cause of drug‐resistant paediatric epilepsy and amenable to successful neurosurgical resection. FCD ILAE Type IIb the most common subtype, brain somatic mutations affecting mTOR pathway play pathogenic role. The aim this study was comprehensively describe genotype–phenotype association 20 patients with histopathologically confirmed FCDIIb using next generation sequencing (NGS) paired blood–brain samples. Methods Clinical...
Abstract Objective We aimed to explore the value of magnetoencephalography in presurgical evaluation patients with posterior cortex epilepsy. Methods A total 39 epilepsy (PCE) and intact (MEG) images were reviewed from August 2019 July 2022. MEG dipole clusters classified into single clusters, multiple scatter dipoles based on tightness criteria. The association surgical outcome classifications was evaluated using Fisher's exact tests. Results Among cases, there 24 cases (61.5%), nine...
BackgroundAltered brain-derived neurotrophic factor (BDNF) concentrations have been detected in the central nervous system tissues and peripheral blood. These alterations are associated with a series of neurological disorders.ObjectiveTo investigate potential causal relationships between genetically determined plasma BDNF levels various diseases using two-sample Mendelian randomisation study.MethodsWe selected single nucleotide polymorphisms strongly related to as instrumental variables....
Neurogenesis, play a vital role in neuronal plasticity of adult mammalian brains, and its dysregulation is present the pathophysiology Parkinson's disease (PD). While subthalamic nucleus deep brain stimulation (STN-DBS) at various frequencies has been proven effective alleviating PD symptoms, influence on neurogenesis remains unclear. This study aimed to investigate effects 1-week electrical 60Hz, 130Hz, 180Hz subventricular zone (SVZ) rats. A hemiparkinsonian rat model was established using...
Magnetoencephalography (MEG) is valuable for guiding resective surgery in patients with epilepsy. However, its value minimally invasive treatment still unknown. This study aims to evaluate the of MEG stereo-electroencephalogram (EEG)-guided radiofrequency thermocoagulation (SEEG-guided RF-TC) magnetic resonance imaging (MRI)-negative epilepsies. Methods: An observational cohort was performed and 19 MRI-negative who underwent SEEG-guided RF-TC our epilepsy center were included. In addition,...
Purpose: Delineation of subtle lesions in magnetic resonance imaging (MRI)-negative patients is great importance preoperative epilepsy evaluation. The aim our study was to explore the diagnostic value novel fluid and white matter suppression (FLAWS) sequence comparison with a voxel-based MRI postprocessing morphometric analysis program (MAP) consecutive cohort non-lesional patients. Methods: Surgical candidates negative finding on an official neuroradiology report were enrolled....
Human performance can be examined using a visual lens. The identification of psychophysical colors and emotional faces with perceptual pathways may remain invalid for simple detection tasks. In particular, how the dorsal ventral processing streams handle discriminative perceptions subsequent cognition activities are obscure. We explored these issues stereoelectroencephalography recordings, which were obtained from patients pharmacologically resistant epilepsy. Delayed match-to-sample...
This study aimed to differentiate temporal-plus epilepsy (TPE) from temporal lobe (TLE) using extraction of radiomics features three-dimensional magnetization-prepared rapid acquisition gradient echo (3D-MPRAGE) imaging data.Data patients with TLE or TPE who underwent surgery between January 2019 and 2021 were retrospectively analyzed. Thirty-three regions interest in the affected hemisphere each patient defined on 3D-MPRAGE images. A total 3531 image extracted patient. Four feature...
Abstract Background Patients with temporal lobe epilepsy (TLE) originating from different seizure onset zones had distinct electrophysiological characteristics and surgical outcomes. In this study, we aimed to investigate the relationship between origin prognosis of TLE, stereoelectroencephalography (SEEG) features. Methods Thirty patients who underwent treatment in our functional neurosurgery department January 2016 December 2017, were enrolled study. All anterior lobectomy after an...
Insular involvement in temporal lobe epilepsy (TLE) has gradually been recognized since the widespread use of stereoelectroencephalography (SEEG). However, correlation between insular and failed surgery remains unclear. In this study, we analyzed surgical outcomes TLE patients who underwent SEEG recordings explored predictors anterior lobectomy (ATL) these with seizures. Forty-one ATL for drug-resistant were examined using recordings. The clinical characteristics, data, postoperative seizure...
Epilepsy affects more than 70 million people in the world. It is characterized by recurrent spontaneous seizures, and it related to many neurological, cognitive, psychosocial consequences. Glutamate neurotransmitter dysfunction has essential functions pathophysiology of epilepsy. In this work, bibliometric analysis was conducted explore trends, frontiers, hotspots global scientific output glutamate epilepsy research past 20 years. The Science Citation Index Expanded Web Core Collection...