A5062671009- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Vagus Nerve Stimulation Research
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Neuroscience and Neural Engineering
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Psychosomatic Disorders and Their Treatments
- Memory and Neural Mechanisms
- Vestibular and auditory disorders
- Glioma Diagnosis and Treatment
- Obstructive Sleep Apnea Research
- Neurobiology of Language and Bilingualism
- Atomic and Subatomic Physics Research
- Neonatal and fetal brain pathology
- Tracheal and airway disorders
- Obsessive-Compulsive Spectrum Disorders
- Fetal and Pediatric Neurological Disorders
- Pharmacological Effects and Toxicity Studies
- Parkinson's Disease Mechanisms and Treatments
- Action Observation and Synchronization
- Memory Processes and Influences
Capital Medical University
2015-2025
Beijing Institute of Neurosurgery
2017
Peking Union Medical College Hospital
1990-1991
Chinese Academy of Medical Sciences & Peking Union Medical College
1990-1991
Epilepsy has been classically seen as a brain disorder resulting from abnormally enhanced neuronal excitability and synchronization. Although it described since antiquity, there are still significant challenges achieving the therapeutic goal of seizure freedom. Deep stimulation anterior nucleus thalamus emerged promising therapy for focal drug-resistant epilepsy; basic mechanism action, however, remains unclear. Here, we show that desynchronization is potential deep by studying local field...
Significance Visual short-term memory (VSTM) is the ability to actively maintain visual information for a short period of time. Classical models posit that VSTM achieved via persistent firing neurons in prefrontal cortex. Leveraging unique spatiotemporal resolution intracranial EEG recordings and analytical power deep neural network uncovering code processing, our results suggest first dynamically extracted multiple representational formats, including higher-order format abstract semantic...
Memory is often conceived as a dynamic process that involves substantial transformations of mental representations. However, the neural mechanisms underlying these and their role in memory formation retrieval have only started to be elucidated. Combining intracranial EEG recordings with deep network models, we provide detailed picture representational from encoding short-term maintenance long-term underlie successful episodic memory. We observed during encoding. Critically, more pronounced...
Objective By studying the surgical outcome of deep brain stimulation (DBS) different target nuclei for patients with refractory epilepsy, we aimed to explore a clinically feasible nucleus selection strategy. Methods We selected epilepsy who were not eligible resective surgery. For each patient, performed DBS on thalamic [anterior thalamus (ANT), subthalamic (STN), centromedian (CMN), or pulvinar (PN)] based location patient's epileptogenic zone (EZ) and possible epileptic network involved....
Objective Pharmaco‐refractory focal motor epileptic seizures pose a significant challenge. Deep brain stimulation (DBS) is recently recognized therapeutic option for the treatment of refractory epilepsy. To identify specific target seizures, we evaluate modulatory effects subthalamic nucleus (STN) because critical role STN in cortico‐subcortical processing. Methods Seven patients with epilepsy who underwent chronic stereoelectroencephalography (SEEG) monitoring were studied presurgical...
Emotion processing is an integral part of everyone's life. The basic neural circuits involved in emotion perception are becoming clear, though the emotion's cognitive remains under investigation. Utilizing stereo-electroencephalograph with high temporal-spatial resolution, this study aims to decipher pathway responsible for discriminating low-arousal and high-arousal emotions. This involves 19 patients pharmacologically resistant epilepsy who participate a delayed match/mismatch sample task...
The mechanisms of vagal nerve stimulation (VNS) for the treatment drug-resistant epilepsy (DRE) remain unclear. This study aimed to measure spontaneous brain activity changes caused by VNS in DRE patients using resting-state functional MRI (rs-fMRI).
Diagnostic challenges exist in the presurgical evaluation of patients with magnetic resonance imaging (MRI) negative cingulate epilepsy (CE) because heterogeneity clinical semiology and lack localizing findings on scalp electroencephalographic (EEG) recordings. We aimed to examine neuroimaging characteristics a consecutive cohort MRI-negative CE focus two image post-processing methods, including MRI morphometric analysis program (MAP) 18F-fluorodeoxyglucose-positron emission tomography-MRI...
Abstract Objective We aimed to explore the value of magnetoencephalography in presurgical evaluation patients with posterior cortex epilepsy. Methods A total 39 epilepsy (PCE) and intact (MEG) images were reviewed from August 2019 July 2022. MEG dipole clusters classified into single clusters, multiple scatter dipoles based on tightness criteria. The association surgical outcome classifications was evaluated using Fisher's exact tests. Results Among cases, there 24 cases (61.5%), nine...
Magnetoencephalography (MEG) is valuable for guiding resective surgery in patients with epilepsy. However, its value minimally invasive treatment still unknown. This study aims to evaluate the of MEG stereo-electroencephalogram (EEG)-guided radiofrequency thermocoagulation (SEEG-guided RF-TC) magnetic resonance imaging (MRI)-negative epilepsies. Methods: An observational cohort was performed and 19 MRI-negative who underwent SEEG-guided RF-TC our epilepsy center were included. In addition,...
Abstract Background Vagus nerve stimulation (VNS) is an effective treatment for patients with refractory epilepsy, yet varied predictive factors and heterogeneous long-term outcomes. Adjustment of VNS parameters critical obtaining favorable efficacy. In this study, we aimed to investigate the outcomes possible in epilepsy. Methods Eighty-six (59 males 27 females) who underwent implantation epilepsy between May 2016 2017 at five Epilepsy Centers were enrolled. The clinical data, including...
We investigated both the metabolic differences and interictal/ictal discharges of anterior nucleus thalamus (ANT) in patients with epilepsy to clarify relationship between ANT epileptic network.Nineteen drug-resistant who underwent stereoelectroencephalography were studied. Metabolic analyzed using [18F] fluorodeoxyglucose-positron emission tomography three-dimensional (3D) visual quantitative analyses. Interictal ictal time-frequency The interictal discharge was analyzed.We found that...