A5073777205- Central Venous Catheters and Hemodialysis
- Cell Adhesion Molecules Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neurological Disease Mechanisms and Treatments
- Vascular Procedures and Complications
- Aquaculture disease management and microbiota
- Fetal and Pediatric Neurological Disorders
- Invertebrate Immune Response Mechanisms
- Neurobiology and Insect Physiology Research
- Acute Kidney Injury Research
- S100 Proteins and Annexins
- Microbial metabolism and enzyme function
- Cerebrospinal fluid and hydrocephalus
- Vagus Nerve Stimulation Research
- Heme Oxygenase-1 and Carbon Monoxide
- EEG and Brain-Computer Interfaces
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Alcohol Consumption and Health Effects
- Cardiac and Coronary Surgery Techniques
- Venous Thromboembolism Diagnosis and Management
- Ultrasound and Hyperthermia Applications
- Eicosanoids and Hypertension Pharmacology
- Bone health and osteoporosis research
- Inflammation biomarkers and pathways
The Affiliated Yongchuan Hospital of Chongqing Medical University
2016-2024
Chongqing Medical University
2016-2024
First Affiliated Hospital of Xi'an Jiaotong University
2022-2024
Institute of Hematology & Blood Diseases Hospital
2023
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2021
Wenzhou Medical University
2021
China Pharmaceutical University
2021
Capital Medical University
2020
Fuzhou University
2020
Scripps Research Institute
2020
Structural and functional studies of HIV envelope glycoprotein (Env) as a transmembrane protein have long been complicated by challenges associated with inherent flexibility the molecule membrane-embedded hydrophobic regions. Here, we present approaches for incorporating full-length, wild-type HIV-1 Env, well C-terminally truncated stabilized versions, into lipid assemblies, providing modular platform Env structural single particle electron microscopy. We reconstitute full-length clone...
Reactive oxygen species (ROS) contribute to cellular redox environment and serve as signaling molecules. Excessive ROS can lead oxidative stress that are involved in a broad spectrum of physiological pathological conditions. Stem cells have unique regulation while cancer frequently show constitutive is associated with the invasive phenotype. Antioxidants been proposed forestall tumor progression targeted oxidants used destroy cells. However, delicate beneficial range levels for stem under...
Osteosarcoma (OS) is well-known for poor prognosis due to its high incidence of proliferation and metastasis. Researches have provided valuable insights into the tumorigenesis S100A9 in some cancers. We aimed understand expression level, functions mechanisms human osteosarcoma first time. The protein was detected 120 tissues 40 normal bone using tissue microarrays analysis. knockdown induced by RNA interference (RNAi) method three cell lines (U2OS, 143B, MG63) applied analyze effects on...
The mechanisms of vagal nerve stimulation (VNS) for the treatment drug-resistant epilepsy (DRE) remain unclear. This study aimed to measure spontaneous brain activity changes caused by VNS in DRE patients using resting-state functional MRI (rs-fMRI).
Toll-like receptors (TLRs), which are essential components of the innate immune response, play an important role in acute kidney injury (AKI). receptor 2 (TLR2) is constitutively expressed tubular epithelial cells and participates cisplatin-induced AKI. The autophagy a dynamic catabolic process that maintains intracellular homeostasis, involved pathogenesis Recent studies demonstrate PI3K/Akt signaling pathway regulates response to various stimuli. Therefore, we propose cisplatin might...
Renalase, a novel secretory flavoprotein with amine oxidase activity, is secreted into the blood by kidneys and hypothesized to participate in pressure (BP) regulation. We investigated associations of renalase BP risk hypertension examining single nucleopeptide polymorphism (SNPs), serum levels, renal expression humans.① Subjects (n = 514) from original Baoji Salt-Sensitive Study cohort were genotyped investigate association SNPs longitudinal changes during 14 years follow-up. ② Two thousand...
Rationale: Transplant rejection is a major impediment to long-term allograft survival, in which the actions of immune cells are fundamental importance.However, cell dynamics and local intercellular communication acute cardiac not completely clear.Methods: Here we performed single-cell RNA sequencing on CD45 + isolated from grafts spleens model murine heterotopic heart transplantation.Moreover, applied unsupervised clustering, functional enrichment analysis, trajectory construction analysis...
Chronic kidney disease (CKD) poses a formidable challenge for public healthcare worldwide as vast majority of patients with CKD are also at risk accelerated cardiovascular and death. Renal fibrosis is the common manifestation that usually leads to end-stage renal although molecular events leading chronic eventually failure remain be fully understood. Nonetheless, emerging evidence suggests an aberrant activation PI3Kγ signaling may play important role in regulating profibrotic phenotypes....
To study and compare the effect of neutrophil elastase inhibitors (GW311616A sivelestat) on proliferation apoptosis U937 cells.Inhibitory effects GW311616A sivelestat cells were assayed by MTT assay. The morphologic changes detected transmission electron microscope, was observed AnnexinV-FITC/PI staining. cell cycle flow cytometry. expression NE in indirect immunofluorescence, variations content activity measured through ELISA assay colorimetric method.MTT showed that both could inhibit a...
Abstract Adipose tissue CD11c + myeloid cell is an independent risk factor associated with obesity and metabolic disorders. However, the underlying molecular basis remains elusive. Here, we demonstrated that liver kinase B1 (Lkb1), a key bioenergetic sensor, involved in cell-mediated immune responses diet-induced obesity. Loss of Lkb1 cells results resistance but lower glucose tolerance, which accompanies tissue-specific abnormalities. The accumulation CD80’s expression deficient...
Angioplasty balloon rupture is a rare complication during percutaneous transluminal angioplasty (PTA). Conventional approach to retrieve circumferentially ruptured balloons open surgery. This study examined the feasibility of novel which can remove PTA in vascular access.
Arteriovenous (AV) grafts are an alternative vascular access for chronic hemodialysis. AV graft failure is often due to stenosis of the feeding artery, graft, or draining vein. We report four cases dysfunction and rarely caused by delamination dissection. Two males two females aged 47-67 years had been on Ultrasound examination detected dissection between 1 33 months after Acuseal implantation. were successfully treated with stenting partial replacement, respectively. False lumen volume...