A5042274114- Blood Pressure and Hypertension Studies
- Sodium Intake and Health
- Cardiovascular Health and Disease Prevention
- Birth, Development, and Health
- Heart Rate Variability and Autonomic Control
- Microbial metabolism and enzyme function
- Chronic Kidney Disease and Diabetes
- Nutritional Studies and Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced Glycation End Products research
- Heme Oxygenase-1 and Carbon Monoxide
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Renin-Angiotensin System Studies
- Renal function and acid-base balance
- Alcohol Consumption and Health Effects
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Hormonal Regulation and Hypertension
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Eicosanoids and Hypertension Pharmacology
First Affiliated Hospital of Xi'an Jiaotong University
2021-2025
Elevated blood pressure (BP) in childhood is associated with adult hypertension and arterial stiffness. However, the effect of long-term time target range (TTR) for BP since on risk stiffness midlife remains unclear. The purpose this study was to determine independent association TTR systolic (SBP) from adulthood. This used data ongoing cohort Hanzhong Adolescent Hypertension Study. SBP-TTR assessed over 36 years, ranges SBP defined as 90th 95th percentile age, sex, height childhood, 110 130...
Vascular aging, as assessed by structural and functional arterial properties, is an independent predictor of cardiovascular outcomes. We aimed to explore the associations individual risk factors from childhood midlife their accumulation over a 30-year span with vascular aging in midlife.Using data ongoing cohort Hanzhong Adolescent Hypertension study, 2180 participants aged 6 18 years at baseline were followed for 30 years. Distinct trajectories systolic blood pressure (SBP), body mass index...
Recent evidence indicates that long-term visit-to-visit blood pressure variability (BPV) may be associated with risk of cardiovascular disease. We, therefore, aimed to determine the potential associations BPV from childhood middle age subclinical kidney damage (SKD) and albuminuria in adulthood.Using data ongoing cohort Hanzhong Adolescent Hypertension study, which recruited children adolescents aged 6 18 years at baseline, we assessed by SD average real (ARV) for 30 (6 visits). Presence SKD...
Objective: Pregnancy-associated plasma protein-A2 (PAPP-A2) is the homolog of PAPP-A in vertebrate genome and its role protecting against salt-induced hypertension salt-sensitive rats has been confirmed. We sought to examine associations PAPP-A2 levels genetic variants with salt sensitivity, blood pressure (BP) changes incidence humans. Methods: Eighty participants (18–65 years old) sequentially consuming a usual diet, 7-day low-salt diet (3.0 g/day) high-salt (18 g/day). In addition, we...
Renalase, a novel secretory flavoprotein with amine oxidase activity, is secreted into the blood by kidneys and hypothesized to participate in pressure (BP) regulation. We investigated associations of renalase BP risk hypertension examining single nucleopeptide polymorphism (SNPs), serum levels, renal expression humans.① Subjects (n = 514) from original Baoji Salt-Sensitive Study cohort were genotyped investigate association SNPs longitudinal changes during 14 years follow-up. ② Two thousand...
Background: Uromodulin, also named Tamm Horsfall protein, has been associated with renal function and regulation of sodium homeostasis. We aimed to examine the associations serum uromodulin levels its genetic variants longitudinal blood pressure (BP) changes hypertension incidence/risk. Methods: A total 514 participants from original Baoji Salt-Sensitive Study cohort were genotyped variations in gene BP incidence over 8 years follow-up. In addition, 2,210 subjects Hanzhong Adolescent...
Neural precursor cell expressed developmentally downregulated 4-like (NEDD4L), a member of the E3 ubiquitin-protein ligases, encoded by NEDD4L gene, was found to be involved in salt sensitivity regulating sodium reabsorption salt-sensitive rats. The authors aimed explore associations genetic variants with sensitivity, blood pressure (BP) changes and hypertension incidence Chinese adults. Participants from 124 families Northern China Baoji Salt-Sensitive Study Cohort 2004, who received...
Background and aims Obesity is an independent risk factor for cardiovascular disease development. Here, we aimed to examine compare the predictive values of three novel obesity indices, lipid accumulation product (LAP), visceral adiposity index (VAI), triglyceride-glucose (TyG) index, subclinical organ damage. Methods A total 1,773 healthy individuals from Hanzhong Adolescent Hypertension Study cohort were enrolled. Anthropometric, biochemical, urinary albumin-to-creatinine ratio (uACR),...
Abstract The E‐proteinoid 3 receptor (PTGER3), a member of the prostaglandin E2 (PGE2) subtype receptor, belongs to G‐protein‐coupled superfamily receptors. Animal studies have demonstrated its involvement in salt sensitivity by regulating sodium reabsorption. This study aimed investigate association between genetic variants PTGER3 and sensitivity, longitudinal blood pressure (BP) changes, incidence hypertension Chinese adults. A chronic intake intervention was conducted involving 514 adults...
Albuminuria is a marker of vascular dysfunction and associated with chronic renal cardiovascular diseases. Data on the association between longitudinal patterns weight change early in life albuminuria later are limited. We aimed to identify body mass index (BMI) trajectory across 30-year span evaluate its middle-age albuminuria.Of 4623 participants aged 6-18-year-old recruited by Hanzhong Adolescent Hypertension Study cohort northern China from March 10, 1987 June 3, 2017, total 1,825...
Abstract Normoalbuminuria has recently been associated with increased cardiovascular risk, and vascular aging is proposed as the early manifestation of disease. Here, authors aimed to examine association high‐normal albuminuria in a Chinese cohort. From our previously established cohort, 1942 participants estimated glomerular filtration rate ≥60 mL/min/1.73 m 2 or urinary albumin‐creatinine ratio (UACR) <30 mg/g were enrolled. Brachial‐ankle pulse wave velocity (baPWV) ≥1400 cm/s and/or...
Objective: Vascular aging, as assessed by structural and functional arterial properties, is an independent predictor of cardiovascular outcomes. In this study, we aimed to investigate the associations ultra long-term blood pressure (BP) variability from childhood midlife with vascular aging in midlife. Methods: Using data longitudinal cohort Hanzhong Adolescent Hypertension Study, 2065 participants aged 6–18 years were enrolled followed up seven visits over 30 years. Ultra BP (BPV) was...