Group 2 innate lymphoid cells (ILCs) are thought to contribute the pathogenesis of atopic dermatitis (AD). IL-4 stimulates T helper type (Th2) and ILC2s proliferate produce cytokines. Dupilumab, an antibody against receptor, is used in AD therapy. We speculated that its efficacy might involve blocking activation Th2 via IL-4. Here, we examined circulating 27 Japanese patients with before after administration dupilumab. Between 0 4 months dupilumab administration, percentages were decreased....

We previously generated a transgenic mouse line expressing skin-specific IL-33 (IL33tg mice) and showed that elicits group 2 innate lymphoid cell (ILC2)-dependent atopic dermatitis-like skin inflammation. ILC2s are believed to be tissue-resident cells under steady-state conditions, but the dynamics of ILC2 migration not fully understood. sorted from draining lymph nodes IL33tg mice analyzed their transcriptomes using single-cell RNA sequencing technique, which revealed had split into two...

The genome of mice with the H-2aw18 haplotype has a deletion approximately 80 kilobases in H-2 class III region chromosome 17. Mice that are homozygous for mutation die soon after birth. A functional form steroid 21-hydroxylase (21-OHase) is encoded by deleted DNA fragment, and homozygotes deficient this enzyme. 21-OHase catalyzes conversion progesterone to deoxycorticosterone during adrenal steroidogenesis mice; therefore, unable synthesize corticosteroids. also includes gene complement...

Dupilumab was effective for 53 patients with moderate-to-severe AD in our daily practice. TARC reduction, however, did not necessarily reflect improved AD.

Autosomal recessive congenital ichthyosis (ARCI) is an entity of rare genetic skin disorders with abnormal keratinization (1).Harlequin the most severe type ARCI, usually caused by truncation mutations in ABCA12.In subtypes such as lamellar ichthy osis (LI) and, ichthyosiform erythroderma (CIE) TGM1, ABCA12, NIPAL4, ALOXE3, ALOX12B, CERS3, CYP4F22 and PNPLA1 have been reported (2-4).Mutations gene encoding NIPA-like domain containing 4 protein (NIPAL4/ichthyin) (5), identified approximately...

Patients with generalized pustular psoriasis (GPP) often present symptoms that must be differentiated from sepsis. Procalcitonin (PCT) and presepsin (P-SEP) are widely used as biomarkers for sepsis; therefore, we examined the serum PCT P-SEP levels in patients psoriatic diseases. The enrolled included 27 vulgaris (PV) (22 males, 5 females; mean age 47.7 years), 12 arthritis (PsA) (8 4 51.3 15 GPP (10 63.7 years). PV, PsA, were 0.01 ng/mL (25th-75th percentile; 0.00-0.03), 0.013 (0.00-0.03),...

The most important side effect of pirfenidone is photosensitivity caused by the phototoxic effect. Here, we report a rare case photosensitive drug eruption due to photoallergic reaction, which was proven through photopatch test and DLST. Pirfenidone medicine for idiopathic pulmonary fibrosis (IPF) released in 2008. exhibits both anti-inflammatory antifibrotic effects, thereby extends progression-free survival time patients with IPF.1 photosensitivity, whose incidence as high 51.7% clinical...

Dear Editor, Chronic hepatitis B virus (HBV) infection is a major cause of cirrhosis and hepatocellular carcinoma, affecting 370 million people worldwide.1 It can also lead to death in de novo acute or reactivated HBV caused by immunosuppressive drugs. In the field dermatology, treatment with biologics for psoriasis other conditions including JAK inhibitors atopic dermatitis (AD) has become therapeutic issue due risk viral reactivation carriers HBV-related previously infected individuals.2...

Abstract Atopic dermatitis (AD) is the most common inflammatory skin disease affecting people of all age groups worldwide. To our knowledge, there are currently no studies estimating effectiveness tacrolimus ointment and dupilumab as a combination therapy for AD. Thus, here we describe safety in with facial rashes patients Overall, included 109 who newly received from April 2018 to July 2020 Dermatology Department Hyogo College Medicine Hospital. Of them, 60 were treated ointment....

We investigated the usefulness of Atopic Dermatitis Control Tool (ADCT) in patients with AD treated dupilumab daily clinical practice. The ADCT score correlated scores other measurement instruments (POEM, DLQI, and EASI) during after treatment. Furthermore, were <7 most who receiving therapy or those bio-free remission discontinuation therapy.

A case of adalimumab-induced interstitial lung disease that was successfully controlled with ixekizumab in a patient psoriatic arthritis. Dear Editor, TNF-α inhibitors, including adalimumab (ADA), increase serum Krebs von den Lungen (KL)-6 levels or without the occurrence (ILD).1, 2 Herein, we report ADA-induced ILD (IXE) Case: 60-year-old man history moderate psoriasis presented as an outpatient exacerbation rash. At previous hospital, ADA monotherapy had been used treatment for 16 months...

ABSTRACT A 70‐year‐old man’s chronic erythematous skin lesion in the extremity had developed into a tumour one year before his first visit at our hospital. biopsy showed atypical lymphocyte‐like cells, and immunostaining identified cells as CD3+, CD4+, CD5+ FOXP3+. Single‐cell RNA sequencing (scRNA‐seq) analysis using BD Rhapsody revealed higher expression of CD3 , CD4 CD5 FOXP3 genes group that highly expressed genes, such PCNA S/M phase, which is agreement with immunofluorescence staining...