A5025779338- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Osteoarthritis Treatment and Mechanisms
- Orthopedic Infections and Treatments
- Mesenchymal stem cell research
- Hip disorders and treatments
- Periodontal Regeneration and Treatments
- Knee injuries and reconstruction techniques
- Tendon Structure and Treatment
- Hip and Femur Fractures
- Laser Applications in Dentistry and Medicine
- Venous Thromboembolism Diagnosis and Management
- Advanced materials and composites
- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Cellular Mechanics and Interactions
- Lower Extremity Biomechanics and Pathologies
- Proteoglycans and glycosaminoglycans research
- Bone and Joint Diseases
- Pelvic and Acetabular Injuries
- Silk-based biomaterials and applications
- Bone Metabolism and Diseases
- Spine and Intervertebral Disc Pathology
- Musculoskeletal synovial abnormalities and treatments
- Innovations in Medical Education
University of Malaya
2014-2025
General Electric (Israel)
2025
Jabatan Perkhidmatan Awam Malaysia
2024
Misurata University
2017
Faculty (United Kingdom)
2014
Hospital Kuala Lumpur
2014
Chonnam National University Hwasun Hospital
2008-2014
Orthopaedic Research
2012
University Malaya Medical Centre
2006-2011
International University of Africa
2007
Abstract The use of mesenchymal stem cells (MSCs) for cartilage repair has generated much interest owing to their multipotentiality. However, significant presence in peripheral blood (PB) been a matter debate. objectives this study are isolate and characterize MSCs derived from PB and, compare chondrogenic potential MSC bone marrow (BM). BM 20 patients were isolated characterized. From 2 ml BM, 5.4 ± 0.6 million 10.5 0.8 adherent cells, respectively, obtained by cell cultures at passage 2....
The Asia Pacific Society of Infection Control (APSIC) launched the APSIC Guidelines for Prevention Surgical Site Infections in 2018. This document describes guidelines and recommendations setting prevention surgical site infections (SSIs). It aims to highlight practical a concise format designed assist healthcare facilities at region achieving high standards preoperative, perioperative postoperative practices.The were developed by an appointed workgroup comprising experts region, following...
Pulse electromagnetic fields (PEMFs) have been shown to recruit calcium-signaling cascades common chondrogenesis. Here we document the effects of specified PEMF parameters over mesenchymal stem cells (MSC) chondrogenic differentiation. MSCs undergoing chondrogenesis are preferentially responsive an efficacy window defined by field amplitude, duration and frequency exposure. Contrary conventional practice administering prolonged repetitive exposures PEMFs, optimal outcome is achieved in...
The use of growth differentiation factor 5 (GDF-5) in damaged tendons has been shown to improve tendon repair. It hypothesized that further improvements may be achieved when GDF-5 is used promote cell proliferation and induce tenogenic human bone marrow-derived mesenchymal stem cells (hMSCs). However, the optimal conditions required produce these effects on hMSCs have not demonstrated previous studies. A study determine exposed different concentrations (0, 5, 25, 50, 100 500 ng/ml) was thus...
Stem cell differentiation is guided by contact with the physical microenvironment, influence both topography and mechanical properties of matrix. In this study, combined effect substratum nano-topography stiffness in directing mesenchymal stem (MSC) chondrogenesis was investigated. Three polyesters varying were thermally imprinted to create nano-grating or pillar patterns same dimension. The surface nano-patterned substrate coated chondroitin sulfate (CS) provide an even chemistry,...
Alendronate inhibits osteoclastic activity. However, some studies suggest alendronate also has effects on osteoblast We hypothesized would enhance osteoblastic differentiation without causing cytotoxicity of the osteoblasts. evaluated effect osteogenic mouse mesenchymal stem cells. D1 cells (multipotent cells) were cultured in medium for 7 days and then treated with 2 before being subjected to various tests using MTT assays, Alizarin Red, enzyme-linked immunosorbent assay, energy-dispersive...
The present study was conducted to establish the amount of mechanical strain (uniaxial cyclic stretching) required provide optimal tenogenic differentiation expression in human mesenchymal stromal cells (hMSCs) vitro, view its potential application for tendon maintenance and regeneration. Methods. In study, hMSCs were subjected 1 Hz uniaxial stretching 6, 24, 48, 72 hours; compared unstretched cells. Changes cell morphology observed under light atomic force microscopy. tenogenic, osteogenic,...
Background Casting and splinting are crucial components of fracture management, making it essential for medical students to acquire proper application skills during their orthopaedic rotations. In this study, the authors aimed investigate potential enhancement skill acquisition through inclusion an instructional video. Methods The study was conducted at a tertiary education centre in Malaysia July 2015, convenience sampling final-year used. sample consisted 108 who were assigned into three...
Surgical site infections (SSIs) are a persistent challenge in healthcare, contributing significantly to patient morbidity, mortality, and healthcare costs. Despite advancements preventive measures, SSIs remain prevalent, especially countries like Malaysia where rates higher than high-income nations. A prospective, cohort study was conducted at the University Malaya Medical Center (UMMC), Malaysia, from November 2020 May 2023. Clinical microbiological data were collected, logistic regression...
To date, the molecular signalling mechanisms which regulate growth factors-induced MSCs tenogenic differentiation remain largely unknown. Therefore, a study to determine global gene expression profile of in human bone marrow stromal cells (hMSCs) using factor 5 (GDF5) was conducted. Microarray analyses were conducted on hMSCs cultures supplemented with 100 ng/ml GDF5 and compared undifferentiated adult tenocytes. Results QuantiGene® Plex assay support use interpretation inferred profiles...
Osteoarthritis (OA) contributes to significant medical and socioeconomic burden in many populations. Its prevalence is expected rise continuously owing the combined effects of aging increase risk factors, including obesity, physical inactivity, joint injuries. Pain a hallmark presentation OA. Topical nonsteroidal anti-inflammatory drugs (NSAIDs) are recommended by international guidelines as an early treatment option management osteoarthritic pain. However, use topical NSAIDs remains low...