A5055294558- Sports Performance and Training
- Sports injuries and prevention
- Nutrition and Health in Aging
- Muscle Physiology and Disorders
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Mitochondrial Function and Pathology
- Diet and metabolism studies
- Cardiovascular and exercise physiology
- Sports Dynamics and Biomechanics
- Muscle activation and electromyography studies
- GDF15 and Related Biomarkers
- Exercise and Physiological Responses
- Children's Physical and Motor Development
- Shoulder Injury and Treatment
- Alzheimer's disease research and treatments
- Lower Extremity Biomechanics and Pathologies
- Genetics, Aging, and Longevity in Model Organisms
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Nerve injury and regeneration
- Trace Elements in Health
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Fatty Acid Research and Health
- Genetics and Physical Performance
Florida Atlantic University
2016-2025
University of California, Berkeley
2023
The Lundquist Institute
2015-2018
Harbor–UCLA Medical Center
2015-2018
Lifespan
2018
Florida State University
2010-2017
UCLA Medical Center
2015-2016
California State University, Fullerton
2009-2015
Eulji University
2015
Daejin University
2015
Abstract The accumulation of dysfunctional mitochondria has been implicated in aging, but a deeper understanding mitochondrial dynamics and mitophagy during aging is missing. Here, we show that upregulating Drp1—a Dynamin-related protein promotes fission—in midlife, prolongs Drosophila lifespan healthspan. We find short-term induction Drp1, sufficient to improve organismal health prolong lifespan, observe midlife shift toward more elongated morphology, which linked the aged flight muscle....
Schick, EE, Coburn, JW, Brown, LE, Judelson, DA, Khamoui, AV, Tran, TT, and Uribe, BP. A comparison of muscle activation between a Smith machine free weight bench press. J Strength Cond Res 24(3): 779-784, 2010-The press exercise exists in multiple forms including the It is not clear though how each mode differs its effect on activation. The purpose this study was to compare anterior deltoid, medial pectoralis major during at lower (70% 1 repetition maximum [1RM]) higher (90% 1RM)...
Zourdos, MC, Jo, E, Khamoui, AV, Lee, S-R, Park, B-S, Ormsbee, MJ, Panton, LB, Contreras, RJ, and Kim, J-S. Modified daily undulating periodization model produces greater performance than a traditional configuration in powerlifters. J Strength Cond Res 30(3): 784–791, 2016—The primary aim of this study was to compare 2 (DUP) models on one-repetition maximum (1RM) strength the squat, bench press, deadlift, total volume (TV) lifted, temporal hormone response. Eighteen male, college-aged (21.1...
High-force activities have demonstrated postactivation potentiation (PAP) and may enhance performance in athletes; however, the efficacy of high-force to generate PAP recreationally trained men remains unclear. The purpose this study was investigate effect back squat volume on vertical jump (VJ) height, ground reaction force (GRF), impulse (IMP), takeoff velocity (TOV) men. Sixteen (age 24.56 +/- 2.10 years, height 174.53 8.54 cm, mass 84.59 14.75 kg, 1 repetition maximum [1RM] 124.71 17.58...
Previous research has investigated the force-time curve characteristics of isometric and dynamic muscle actions; however, few studies have addressed their relationship to exercise velocity-time variables. The purpose this study was investigate relationships between (high pull vertical jump peak velocity rate development [HPPV, HPRVD, VJPV, VJRVD]), (isometric force [IsoPF], body mass adjusted [IsoPF/BM], at different millisecond windows [IsoRFD50-250], [HPPF], [HPPF/BM]), height (VJHeight)....
Uribe, BP, Coburn, JW, Brown, LE, Judelson, DA, Khamoui, AV, and Nguyen, D. Muscle activation when performing the chest press shoulder on a stable bench vs. swiss ball. J Strength Cond Res 24(4): 1028-1033, 2010-The aim of this study was to examine effects surface (bench) an unstable (Swiss ball) muscle dumbbell press. Sixteen healthy men (24.19 ± 2.17 years) performed 1 repetition maximum (1RM) tests for surface. A minimum 48 hours post 1RM, subjects returned perform 3 consecutive...
In addition to skeletal muscle dysfunction, cancer cachexia is a systemic disease involving remodeling of nonmuscle organs such as adipose and liver. Impairment mitochondrial function associated with multiple chronic diseases. The tissue-specific control in not well defined. This study determined respiratory capacity coupling muscle, white tissue (WAT), liver colon-26 (C26) tumor-induced cachexia. Tissues were collected from PBS-injected weight-stable mice, C26 mice moderate (10% weight...
Aerobic training (AT) can support brain health in Alzheimer's disease (AD); however, the role of resistance (RT) AD is not well established. Aside from direct effects on brain, exercise may also regulate function through secretion muscle-derived myokines. Aims. This study examined AT and RT hippocampal BDNF IGF-1 signaling, β-amyloid expression, myokine cathepsin B triple transgenic (3xTg-AD) model AD. 3xTg-AD mice were assigned to one following groups: sedentary (Tg), aerobic trained...
Cuprous copper [Cu(I)] is an essential cofactor for enzymes that support many fundamental cellular functions including mitochondrial respiration and suppression of oxidative stress. Neurons are particularly reliant on production ATP, with neurodegenerative diseases, Parkinson’s disease, associated diminished function. The gene MBLAC1 encodes a ribonuclease targets pre-mRNA replication-dependent histones, proteins recently found in yeast to reduce Cu(II) Cu(I), when mutated disrupt ATP...
Starting stance plays an important role in influencing short-distance sprint speed and, therefore, the ability to reach a ball during sport play. The purpose of this study was evaluate 4 different starting stances on time. Twenty-six male and female collegiate volleyball players volunteered participate 1 testing session. Each subject performed 3 15-ft trials at each (P-parallel, FS-false step, S-staggered, SFS-staggered false step) random order. Analysis variance revealed that there no...
Abstract Exposure to maternal over-nutrition in utero is linked with developmental programming of obesity, metabolic syndrome and cardiovascular disease offspring, which may be exacerbated by postnatal high-fat (HF) diet. Skeletal muscle mitochondrial function contributes substrate metabolism impaired disease. We examined respiration male female mice exposed HF diet , followed postweaning until middle age. After exposure control (Con) or (45% kcal fat; 39.4% lard, 5.5% soybean oil),...
Eccentric muscle actions cause damage and lead to delayed-onset soreness (DOMS), which may impair performance. The purpose of this study was examine the effect DOMS on elbow flexion strength rate velocity development (RVD). Nineteen college male subjects performed 6 tests (pre- posteccentric every 24 hours for 4 days). In preeccentric tests, each subject reported his arm pain then did 5 concentric repetitions flexion/extension an isokinetic dynamometer at 240 degrees x s(-1). Each completed...
Prominent pathological features of Huntington’s disease (HD) are aggregations mutated Huntingtin protein (mHtt) in the brain and neurodegeneration, which causes characteristic motor (such as chorea dystonia) non-motor symptoms. However, numerous systemic peripheral deficits HD have gained increasing attention recently, since those factors likely modulate progression, including pathology. While whole-body metabolic abnormalities organ-specific pathologies been relatively well described,...
Eurich, AD, Brown, LE, Coburn, JW, Noffal, GJ, Nguyen, D, Khamoui, AV, and Uribe, BP. Performance differences between sexes in the pop-up phase of surfing. J Strength Cond Res 24(10): 2821-2825, 2010-Surfing is a dynamic sport that multidirectional nature requires peak performance variable ocean conditions. Its growing popularity among female population has stirred curiosity as to whether women can will 1 day face their male counterparts head-to-head competition at top levels. The purpose...
Older women exhibit blunted skeletal muscle hypertrophy following resistance training (RT) compared to other age and gender cohorts that is partially due an impaired regenerative capacity. In the present study, we examined whether β-hydroxy-β-methylbutyrate (HMB) provision aged female rodents would enhance mechanisms facilitate RT-induced myofiber growth. Nineteen-month old Sprague-Dawley rats were randomly divided into three groups: HMB (0.48 g/kg/d; n = 6), non-HMB (n control 4). groups...
Cachexia is a life-threatening complication of cancer traditionally characterized by weight loss and muscle dysfunction. Cachexia, however, systemic disease that also involves remodeling nonmuscle organs. The liver exerts major control over metabolism, yet its role in cachexia not well understood. To advance the understanding how contributes to cachexia, we used quantitative proteomics bioinformatics identify hepatic pathways cellular processes dysregulated mice with moderate severe colon-26...
Cachexia is a life-threatening complication of cancer that occurs in up to 80% patients with advanced cancer. reflects the systemic consequences and prominently features unintended weight loss skeletal muscle wasting. impairs treatment tolerance, lowers quality life, contributes cancer-related mortality. Effective treatments for cachexia are lacking despite decades research. High-throughput omics technologies increasingly implemented many fields including stimulate discovery disease biology...
Tran, TT, Brown, LE, Coburn, JW, Lynn, SK, Dabbs, NC, Schick, MK, EE, Khamoui, AV, Uribe, BP, and Noffal, GJ. Effects of different elastic cord assistance levels on vertical jump. J Strength Cond Res 25(12): 3472-3478, 2011-Currently, little research has been conducted using body weight reduction (BWR) as a means to enhance The purpose this study was determine the effects jump height (JH), takeoff velocity (TOV), relative ground reaction force (rGRF), impact (RIF), descent (DV). Thirty...
The purpose of this study was to compare muscle activation the anterior deltoid, medial and pectoralis major during a Smith machine free weight bench press at lower (70% 1RM) higher (90% intensities. Fourteen experienced (age, 19.9 ± 2.1 years; height, 176.3 7.5 cm; mass, 88.5 19.4 kg) twelve inexperienced 20.5 179.8 8.0 75.5 10.4 men completed two testing sessions. Investigators counterbalanced order conditions (free weight, machine) randomized loads (70 90% control for biasing each...