A5051646748- Adipokines, Inflammation, and Metabolic Diseases
- Fatty Acid Research and Health
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Food composition and properties
- Cancer, Lipids, and Metabolism
- High Altitude and Hypoxia
- Gut microbiota and health
- Metabolism and Genetic Disorders
- Diet, Metabolism, and Disease
- Regulation of Appetite and Obesity
- Muscle metabolism and nutrition
- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
- Coffee research and impacts
- Traumatic Brain Injury and Neurovascular Disturbances
- Metabolism, Diabetes, and Cancer
- Nutrition and Health in Aging
- Metabolomics and Mass Spectrometry Studies
- Exercise and Physiological Responses
- Receptor Mechanisms and Signaling
- Amino Acid Enzymes and Metabolism
- Obesity, Physical Activity, Diet
- Peroxisome Proliferator-Activated Receptors
- Probiotics and Fermented Foods
University of Guelph
2015-2024
Savannah River National Laboratory
2024
University of Dundee
2019-2022
University of Copenhagen
2009
University of Alberta
1998-2008
University of Toronto
2004
Copenhagen University Hospital
2004
University of California, Riverside
1984-1986
Common beans contain non-digestible fermentable components (SCFA precursors) and phenolic compounds (phenolic acids, flavonoids anthocyanins) with demonstrated antioxidant anti-inflammatory potential. The objective of the present study was to assess in vivo effect cooked whole-bean flours, differing compound levels profiles, a mouse model acute colitis. C57BL/6 mice were fed 20 % navy bean or black flour-containing diet an isoenergetic basal (BD) for 2 weeks before induction experimental...
Adiponectin, a protein secreted from adipose tissue, has been shown to have anti-diabetic and anti-inflammatory effects, but its regulation is not completely understood. Long-chain n-3 fatty acids eicosapentaenoic acid (20:5n-3; EPA) docosahexaenoic (22:6n-3; DHA) may be involved in adiponectin as they are potential ligands for peroxisome proliferator-activated receptor-γ (PPARγ), key transcription factor the gene. To examine this, 3T3-L1 adipocytes were incubated with 125 µmol·L –1 EPA,...
Adiponectin, an anti-inflammatory and insulin-sensitizing protein secreted from adipose tissue, may be modulated by dietary fatty acids, although the mechanism is not fully known. Our objective was to investigate effect of long-chain n-3 polyunsaturated acids (PUFAs) on adiponectin in cultured human adipocytes, elucidate role peroxisome proliferator-activated receptor-γ (PPARγ) this regulation. Isolated adipocytes were for 48 h with 100 µmol/l eicosapentaenoic acid (C20:5n-3, EPA),...
Twenty-one soluble proteins, five tRNAs, and three protein-nucleic acid complexes were studied in a systematic manner with regard to their crystallization behavior from polyethylene glycol ammonium sulfate solutions the presence of 0 1.5% beta-octyl glucoside. Our observations suggest that this neutral detergent does influence very positive way growth characteristics macromolecules included experiment. In general, more reproducible rapid was noted an increased number large individual...
To determine the effect of feeding formula containing long-chain PUFA (LCP) on immune function, healthy term infants were randomised at age 2 weeks to either a standard (Formula; n 14) or same supplemented with LCP 20 : 4 -6 and 22 6 -3 (Formula+LCP; 16). Peripheral blood was collected measure cell response (the rate [ 3 H]thymidine uptake cytokine production after stimulation phytohaemagglutinin (PHA)). Compared cells from receiving only human milk (HM), in PHA, but not IL-2 production,...
Paracrine interactions between adipocytes and macrophages contribute to chronic inflammation in obese adipose tissue. Dietary strategies mitigate such include long-chain polyunsaturated fatty acids, docosahexaenoic (DHA) eicosapentaenoic (EPA) which act through PPARγ-dependent independent pathways. We utilized an vitro co-culture model designed mimic the ratio of macrophages:adipocytes tissue, whereby murine 3T3-L1 were cultured with RAW 264.7 direct contact, or separated by a trans-well...
Flaxseed (FS), a dietary oilseed, contains variety of anti-inflammatory bioactives, including fermentable fiber, phenolic compounds (lignans), and the n-3 polyunsaturated fatty acid (PUFA) α-linolenic acid. The objective this study was to determine effects FS its PUFA-rich kernel or lignan- soluble fiber-rich hull on colitis severity in mouse model acute colonic inflammation. C57BL/6 male mice were fed basal diet (negative control) supplemented with 10% FS, 6% kernel, 4% for 3 wk prior...
Structural characteristics and baking conditions influence the metabolic responses to carbohydrate-containing foods. We hypothesized that consumption of whole wheat or sourdough breads would have a favourable effect on biomarkers glucose homeostasis after first second meals, compared with those for white bread. Ten overweight volunteers consumed 50 g available carbohydrate each four (white, wheat, sourdough, barley) followed 3 h later by standard meal. Blood was sampled following bread...