A5085077287- Extracellular vesicles in disease
- Pulmonary Hypertension Research and Treatments
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Alkaloids: synthesis and pharmacology
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Plant-based Medicinal Research
- HIV-related health complications and treatments
- Chronic Kidney Disease and Diabetes
- Berberine and alkaloids research
- Innovation and Knowledge Management
- Estrogen and related hormone effects
- Cancer Cells and Metastasis
- Lung Cancer Diagnosis and Treatment
- Pharmaceutical and Antibiotic Environmental Impacts
- Cardiac Structural Anomalies and Repair
- Diverse Scientific Research Studies
- Renal and related cancers
- Tuberculosis Research and Epidemiology
- Circular RNAs in diseases
- Chemical Reactions and Isotopes
- Medical Imaging and Pathology Studies
- Computational Drug Discovery Methods
University of Michigan
2021-2024
Pulmonary and Critical Care Associates
2021
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2013-2020
University of Kansas Medical Center
2018-2020
University of Kansas
2018
Bangalore Medical College and Research Institute
2012
Background Podocyte injury is an early feature of diabetic nephropathy (DN). Recently, urinary exosomal Wilm's tumor-1 protein (WT1), shed by renal epithelial cells, has been proposed as a novel biomarker for podocyte injury. However, its usefulness not verified yet. We investigated WT1 in type-1 patients to confirm role non-invasive predicting function decline. Methods The expression exosomes from spot urine samples diabetes mellitus (n = 48) and healthy controls 25) were analyzed. Patients...
Non-invasive renal signatures can help in serial monitoring of diabetic patients. We tested whether urinary exosomal (UE) microRNA (miR) analysis could non-invasively predict pathology rats during the course diabetes. Diabetes mellitus (DM) was induced male Wistar by a single intraperitoneal injection streptozotocin (STZ, 50 mg/kg body weight). Non-diabetic control (CTRL) were injected with vehicle. Insulin (INS) treatment (5U/d, s.c.) provided to 50% DM rats. Urine samples collected at...
Introduction: Lung cancer is the most commonly occurring worldwide accounting for 12.4% of total new cases and also leading cause deaths (18.7%). In India, accounts 5.8% 8.2% deaths. Chemotherapy Radiation therapy plays a major role in treatment especially inoperable cases. this study we evaluated factors which could affect Overall Survival (OS) Disease -Free (DFS) patients with carcinoma treated by Sequential Chemoradiation (CTRT) Concurrent CTRT. Materials Method: A retrospective review...
Abstract Statins, 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors have been shown to improve diabetic nephropathy. However, whether they provide protection via Histone deacetylases (HDAC) inhibition is not clear. We conducted a comparative evaluation of Atorvastatin (AT) versus the non-statin cholesterol-lowering drug, Ezetimibe (EZT) on severity Streptozotocin-treated male Wistar rats were fed cholesterol-supplemented diet and gavaged daily with vehicle, AT or EZT. Control...
Micro-RNAs (miRs) encapsulated inside urinary exosomes (uEs) have the potential as early biomarkers. Previously, we reported that a rise in uE miR-451 predicted albuminuria diabetic rats; however, whether was protective or detrimental, and occurred response to injury general hyperglycemia, unknown. To address this, studied both human rat models of renal disease. In humans, approximately twofold higher subjects with early-stage chronic kidney disease (CKD; serum creatinine < 2.0 mg/dl; n =...
Background Earlier, we reported that the simultaneous exposure of pulmonary arterial smooth muscle cells to HIV proteins and cocaine results in attenuation antiproliferative bone morphogenetic protein receptor‐2 ( BMPR 2) expression without any decrease its mRNA levels. Therefore, this study, aimed investigate micro RNA ‐mediated posttranscriptional regulation 2 expression. Methods Results We identified a network targeting s including miR‐216a be upregulated response Tat‐mediated...
Extracellular vesicles (EVs) have emerged as important mediators in cell-cell communication; however, their relevance pulmonary hypertension (PH) secondary to human immunodeficiency virus (HIV) infection is yet be explored. Considering that circulating monocytes are the source of increased number perivascular macrophages surrounding remodeled vessels PH, this study aimed identify role small EVs and released by HIV-infected monocyte-derived development PH. We report significantly higher...
Objective: Previously, we reported presence of Wilms' tumor 1 (WT1) in urinary exosomes ~50% diabetic (T1D) population without proteinuria as oppose to 100% T1D with proteinuria.Here, investigated if subjects detectable WT1 (UE) progress faster a 2 year follow-up study.Method: 52 (age < 60 years) were enrolled.Urine and blood samples collected for analysis.WT1 immunoblotting was performed on UE isolated by ultracentifugation urine samples.Urine microalbumin, serum creatinine glycated...
Abstract Rationale Extracellular vesicles (EVs) have emerged as important mediators in cell-cell communication and disease pathogenesis; however, their relevance pulmonary hypertension (PH) secondary to HIV infection is yet be explored. Objective To examine the role of circulating small EVs monocyte-derived macrophage (MDM) development HIV-associated PH Methods isolated from plasma HIV-infected drug users non-users with/without supernatants MDMs treated second hit cocaine were studied for...
Over a third of diabetes patients develop diabetic nephropathy. To categorize such subset there is need for non‐invasive biomarker that regulate very early in the pathogenesis. We tested miRNAs urinary exosomes (UE) as candidate molecule using serial urine sample from rats before and during course diabetes. Wistar were injected with streptozotocin (50 mg/kg. body weight). For exosome isolation, samples collected (ND) after induction. Differentially expressed identified small RNA sequencing,...
Abstract One of the most challenging aspects PDAC is intense therapeutic resistance towards radiotherapy. Cellular signaling pathways are tightly regulated to protect and withstand constant DNA-damaging insults. Similarly, pancreatic cancer cells known activate important metabolic events in advent cellular stress. Fuel sources obtained via high flexibility confer on them enhanced survival ability escape therapy-induced cell death. To this end, we aim dissect role altered reprogramming...
Background: The outcome of tuberculosis (TB) treatment is influenced by Human Immunodeficiency Virus (HIV) infection, and known to be less successful when compared HIV uninfected. A clear picture the treatment-outcomes with current strategies in India i.e. Revised National Tuberculosis Control Program(RNTCP)'s Directly observed short course(DOTS) & AIDS Program(NACP)'s ART, factors that influence such outcomes could prove useful improving existing programs. Methods: Objectives: To know type...
Introduction and hypothesis: Intravenous drug use (IVDU) is considered to be one of the important risk factors in development HIV-associated pulmonary arterial hypertension (HPAH). Our previous findings demonstrate that exposure cocaine HIV infected individuals has an additive effect enhancing proliferation smooth muscle cells, thus further amplifying arteriopathy. Furthermore, various studies suggest failure Hippo pathway increased YAP/TAZ activity (PH). Based on this, we hypothesized YAP...
Summary form only given. The study has been an attempt to understand the dimensions of technological developments (TDs) across different phases product life cycle (PLC). is exploratory one, conducted in a sample 63 Indian organizations manufacturing general-purpose machinery. To achieve objectives cross sectional design was adopted conduct study. Eleven processes related development variables were identified from literature and listed four PLC. From results, it evident that TD are point view...
Abstract Large-scale chromosomal alterations, particularly deletions in cancer genomes confer functional advantages to cells via the loss of tumor suppressor genes (TSGs). However, due nature these focal and arm-level deletions, essential house-keeping neighborhood TSGs are potentially lost. We explore emergence metabolic adaptations vulnerabilities that arise collateral genes. In our previous work, we showed genomic locus containing SMAD4 ME2 pancreatic ductal adenocarcinomas forces rely on...