A5056561375- Ion channel regulation and function
- Calcium signaling and nucleotide metabolism
- Aquaculture Nutrition and Growth
- Cardiac electrophysiology and arrhythmias
- Aquaculture disease management and microbiota
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Plant Molecular Biology Research
- Photoreceptor and optogenetics research
- Crustacean biology and ecology
- stochastic dynamics and bifurcation
- Autophagy in Disease and Therapy
- Cellular transport and secretion
- Nanocluster Synthesis and Applications
- Electrochemical Analysis and Applications
- Retinal Development and Disorders
- Infectious Aortic and Vascular Conditions
- Nanomaterials for catalytic reactions
- Chemical Thermodynamics and Molecular Structure
- Reproductive biology and impacts on aquatic species
- Neurobiology and Insect Physiology Research
- Nicotinic Acetylcholine Receptors Study
- Phase Equilibria and Thermodynamics
- Plant Stress Responses and Tolerance
- Aortic aneurysm repair treatments
Zhejiang Hospital
2025
Hefei National Center for Physical Sciences at Nanoscale
2021-2024
University of Science and Technology of China
2019-2024
CAS Key Laboratory of Urban Pollutant Conversion
2022
China National Petroleum Corporation (China)
2020
PetroChina Southwest Oil and Gas Field Company (China)
2020
Huazhong University of Science and Technology
2013-2019
Xiangtan University
2016
Guangdong Ocean University
2012
Neuronal ceroid lipofuscinoses (NCLs) are a group of autosomal recessive lysosomal storage diseases. One variant form late-infantile NCL (vLINCL) is caused by mutations membrane protein CLN7, the function which has remained unknown. Here, we identified CLN7 as novel endolysosomal chloride channel. Overexpression increases currents and enlarges endolysosomes through Ca2+/calmodulin-dependent way. Human its yeast homolog exhibit characteristics channels sensitive to channel blockers. Moreover,...
Abstract Cancer stem cells (CSCs) are a sub-population of possessing high tumorigenic potential, which contribute to therapeutic resistance, metastasis and recurrence. Eradication CSCs is widely recognized as crucial factor in improving patient prognosis, yet the effective targeting these remains major challenge. Here, we show that lysosomal cation channel TRPML1 represents promising target for CSCs. highly expressed breast cancer exhibits sensitivity salinomycin, drug known selectively...
Using the icosahedra M<sub>13</sub> (M = Au, Ag, Cu, Pt, Pd) and heteroatom doped Au<sub>18</sub>M clusters as model systems, role of co-adsorbed CO molecule played in oxidation reaction is explored on basis density functional theory (DFT) calculations.
Lysosomes are degradation centers of cells and intracellular hubs signal transduction, nutrient sensing, autophagy regulation. Dysfunction lysosomes contributes to a variety diseases, such as lysosomal storage diseases (LSDs) neurodegeneration, but the mechanisms not well understood. Altering activity examining its impact on occurrence development disease is an important strategy for studying lysosome-related diseases. However, methods dynamically regulate function in living or animals still...
Large-conductance calcium-activated potassium (BK) channels regulate the electric properties and neurotransmitter release in excitable cells. Its auxiliary β2 subunits not only enhance gating, but also confer inactivation via a short-lived preinactivated state. However, mechanism of enhancement preinactivation BK by remains elusive. Using our newly developed methods, we demonstrated that electrostatic forces played crucial role forming multiple complementary pairs binding sites between α β...
KCNQ1 channels play vital roles in cardiovascular, gastric and other systems. The conductance dynamics of could be modulated by different single transmembrane helical auxiliary proteins (such as KCNE1, KCNE2 others). In this study, detail function modulations regions KCNE1 or were examined using combinational methods electrophysiology, immunofluorescence, solution NMR related backbone flexibility analysis. the presence N-terminus, decreased surface expression consequent low activities...
Abstract Ca 2+ ions play crucial roles in mediating physiological and pathophysiological processes, yet dynamics local to the source, either from influx via calcium permeable ion channels on plasmic membrane or release internal stores, is difficult delineate. Large-conductance calcium-activated K + (BK-type) channels, abundantly distribute excitable cells often localize proximity of voltage-gated (VGCCs), spatially enabling coupling intracellular signal channel gating regulate excitability...
KCNE β-subunits play critical roles in modulating cardiac voltage-gated potassium channels. Among them, KCNE1 associates with KCNQ1 channel to confer a slow-activated IKs current, while KCNE2 functions as dominant negative modulator suppress the current amplitude of KCNQ1. Any anomaly these channels will lead serious myocardial diseases, such long QT syndrome (LQTS). Trafficking defects have been reported account for pathogenesis LQT5. However, molecular mechanisms underlying forward...
Hydrocarbon dew point (HCDP) is one of the most important quality specifications natural gas. Measuring and predicting HCDP accurately are essential for gas industry. However, comprehensive experimental curve data still rare, knowledge about adopting proper prediction models remains unclear. In view this, determination work by use an improved test system model evaluation based on more than 1000 points have been done to improve aforementioned dilemma. three gravimetrically prepared synthetic...
Lysosomes are essential degradative organelles and signaling hubs within cells, playing a crucial role in the regulation of macroautophagy/autophagy. Dysfunction lysosomes impaired autophagy closely associated with development various neurodegenerative diseases. Enhancing lysosomal activity boosting levels holds great promise as effective strategies for treating these However, there remains lack methods to dynamically regulate living cells or animals. In our recent work, we applied...
Large-conductance Ca2+- and voltage-activated potassium (BK) channels are widely expressed in tissues. As a voltage calcium sensor, BK play significant roles regulating the action potential frequency, neurotransmitter release, smooth muscle contraction. After associating with auxiliary β2 subunit, mammalian BK(β2) (mouse or human Slo1/β2) exhibit enhanced activation complete inactivation. However, how subunit modulates Drosophila Slo1 channel remains elusive. In this study, by comparing...
Large-conductance calcium-activated potassium (BK) channels regulate the electric properties and neurotransmitter release in excitable cells. Its auxiliary β2 subunits not only enhance gating, but also confer inactivation via a short-lived preinactivated state. However, mechanism of enhancement preinactivation BK by remains elusive. Using our newly developed methods, we demonstrated that electrostatic forces played crucial role forming multiple complementary pairs binding sites between α β...
Sphingosine-1-phosphate (S1P) is a widely expressed biologically active sphingolipid that plays an important role in cell differentiation, migration, proliferation, metabolism and apoptosis. S1P activates various signaling pathways, some of which evoke Ca<sup>2+</sup> signals the cytosol. Few studies have focused on mechanism by evokes neurons. Here, we show global SH-SY5Y cells hippocampal Removal extracellular calcium largely abolished S1P-induced increase intracellular...