A5082183572- Congenital heart defects research
- Adipose Tissue and Metabolism
- Congenital Heart Disease Studies
- Birth, Development, and Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Estrogen and related hormone effects
- Adipokines, Inflammation, and Metabolic Diseases
- Bone and Dental Protein Studies
- Diet and metabolism studies
- Bone health and osteoporosis research
- Breast Cancer Treatment Studies
- Connective tissue disorders research
- Chronic Kidney Disease and Diabetes
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Pregnancy and preeclampsia studies
- Pulmonary Hypertension Research and Treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Circadian rhythm and melatonin
- Breast Lesions and Carcinomas
- Cancer and Skin Lesions
- Lysosomal Storage Disorders Research
- Neuroethics, Human Enhancement, Biomedical Innovations
- Autism Spectrum Disorder Research
- Multiple and Secondary Primary Cancers
Universidad Juárez del Estado de Durango
2004-2024
Autonomous University of Durango
2011-2024
Mexican Social Security Institute
2002-2022
Universidad de Guadalajara
2000
Universidad de Occidente
2000
Abstract Background. Pregnancy is a condition that favors oxidative stress by reactive oxygen species. Oxidative involved in the etiopathogenesis of disorders pregnancy such as pre‐eclampsia. An antioxidant effect estrogens has been described and putative role them antioxidants proposed. The aim this work was to evaluate vitro properties dehydroepiandrosterone sulfate, estradiol, estriol, progesterone, testosterone, five steroid hormones present maternofetal circulation. Methods. were...
Millions of microorganisms compose the human gut microbiota, essential for maintaining metabolic health. Recent research has shown that microbiome people with obesity and diabetes changes significantly in composition functionality. These are characterized by a decrease diversity an overrepresentation certain microbial agents have detrimental effects. Dysbiosis, imbalance contributes to development progression disorders several ways, including increased intestinal permeability, inflammation,...
Cardiovascular disease (CVD) is a major cause of mortality in the Republic Mexico, and metabolic syndrome, complex CVD risk factors, increasingly prevalent. To date, however, there have been few studies genetic epidemiology syndrome Mexico. As first step implementing GEMM Family Study, large, multicenter collaborative study, we recruited 375 individuals 21 extended families, without ascertainment on disease, at 9 medical institutions across Participants were measured for anthropometric...
Objective . To evaluate the association between Haptoglobin (HP) gene polymorphisms with inflammatory status in obese subjects. Materials and Methods A cross-sectional study was carried out. total of 276 apparently healthy men nonpregnant women were enrolled allocated according to HP genotype into 1 / , 2 groups. Distribution genotypes 49, 87, 140 for respectively. The determined using polymerase chain reaction method. multiple linear regression analysis adjusted by age, sex, waist...
Abstract BACKGROUND Cyclophosphamide (CPA) is an alkylating agent widely used as immunosuppressive in the treatment of several autoimmune diseases, including systemic lupus erythematosus. Its teratogenic effect has been well studied different experimental mammalian and non‐mammalian animal models. In humans, 11 cases CPA teratogenesis have documented. CASE We present a case patient with Klippel‐Feil syndrome inadvertently exposed to prednisone utero during first trimester. CONCLUSIONS This...
To evaluate a predictive model of microalbuminuria by using anthropometric, clinical and genetic variables in relatives subjects with diabetic nephropathy.Eligible subjects, aged 18-63 years body mass index<35 kg/m2, first degree patients type 2 diabetes nephropathy were enrolled cross-sectional study. A total 70 individuals compared 60 without microalbuminuria. Based on morning urinary sample, was defined as albumin≥30<300 mg/dL. Genotyping single nucleotide polymorphisms (SNPs) G-174C IL6...
Sinusoidal endothelial liver cells (SECs) have a key role in the pathophysiology of chronic disease. Leptin is an important profibrogenic and proinflammatory cytokine whose expression sinusoidal has not been documented. The authors studied potential rat SECs to express leptin receptor genes. Two cell lines were generated from male by pronase-collagenase perfusion dilution cloning. They characterized according morphology, ploidy, von Willebrand antigen immunoreactivity, CD31 transcription,...
Schizophrenia is a severe mental illness characterized by disconnection from reality, significantly impacting person's ability to function and leading substantial disability. While the exact causes of schizophrenia remain unclear, it understood result combination genetic, neurochemical, environmental factors. The heritability high, although does not follow Mendelian patterns. symptomatology includes both positive symptoms such as hallucinations, delusions, psychotic episodes, negative like...
Breast cancer is a complex disease resulting from the interaction between genetic and environmental factors, addressing them constitutes one of major challenges in treatment this disease. Resistance to therapies represents significant obstacle achieving effective results breast cancer, multiple therapeutic approaches are available address patients. The majority cases show estrogen receptor (ERα) expression, treatments targeting pathway critical their approach. However, emergence resistance...
Pulmonary arterial hypertension (PAH) is a devastating disease characterized by progressive increase in pressure the pulmonary arteries. This leads to vascular remodeling and, eventually, right heart failure. Variants BMPR2 gene, which encodes bone morphogenetic protein receptor type 2, are most common genetic cause of hereditary and idiopathic PAH. These variants disrupt transforming growth factor-beta (TGF-β) signaling pathway, triggering abnormal proliferation artery smooth muscle cells...
Osteogenesis imperfecta is colloquially known as brittle bone disease because it an inherited characterized by a connective tissue disorder that causes decreased mass, increased fragility and abnormalities in skeletal structure. This caused mutation the type I collagen genes, specifically COL1A1 COL1A2, resulting variety of clinical manifestations ranging from mild to lethal. The impact on quality life patients with OI can be complicated, which why they need multidisciplinary management...
Metformin is the first-line antidiabetic therapy for type 2 diabetes in Mexico, despite recent recommendations highlighting alternatives like GLP-1 receptor agonists individuals with obesity. elimination reliant on liver and kidney function, variants transport proteins such as Multidrug Toxin Extrusion Protein 1 (MATE1), MATE2, Organic Cation Transporter (OCT2) can influence its pharmacokinetics. Understanding these variants' frequencies Mexican population crucial tailoring personalized...
This article examines the genetic and clinical features of two main types porphyrias: acute intermittent porphyria (AIP) cutanea tarda (PCT). AIP, a common hereditary disorder in young women, is characterized by severe neurovisceral crises, with abdominal pain, neuromuscular dysfunction psychiatric disturbances, which are caused mutations HMBS gene, affecting heme synthesis, causing intense symptoms nervous gastrointestinal systems. PCT manifests mainly adults, associated photosensitivity,...
Leukemia represents one of the greatest challenges in medical oncology due to its aggressiveness and biological complexity. Immunotherapy has recently emerged as a promising option for treatment leukemias, however, genetic complexity represented challenge it. ALL AML present different alterations, such mutations, chromosomal rearrangements signaling pathways. Currently, several therapies have been investigated applied try treat leukemia, among them, CAR T-cell therapy shown great...
This review explores the connection between genetic factors and psychiatric disorders, emphasizing role of MAOA gene, cortisol, testosterone, their interaction with environmental influences. Specifically, it investigates how gene hormone levels contribute to behavioral tendencies, such as aggression impulsivity, by affecting prefrontal cortex, amygdala, limbic system. The study also considers predispositions are intensified external stressors like trauma, highlighting gene-environment...
The use of tobacco is widespread among men and poses a significant concern for reproductive health. This review synthesizes recent evidence on the impact cigarette smoking spermatogenesis, emphasizing its effects semen quality, hormone levels, metabolic profile, sperm DNA fragmentation, which contribute to infertility. Smoking associated with increased oxidative stress fragmentation in sperm, both impair fertility outcomes. By examining these adverse effects, this underscores importance...
The maternal organism, including the microbiome of oral cavity, vaginal and intestinal microbiome, influences risk pregnancy outcomes related to fetal health even after birth. Recent research reveals that it is not only blood circulation, placenta or amniotic fluid contain bacteria. While interaction bacteria their metabolites with fetus newborn has serious consequences by causing diseases malformations. An alternative for women undergoing cesarean section seeding, a practice involves...
At present, cancer is a global problem, among all the types that exist, one of those was taken into account for this research thyroid cancer, especially associated with predisposing genes RET rearrangement and BRAF gene mutation, which incite rapid exit papillary carcinoma, from MAPK signaling pathways conformational change by mutation in at position (V600E) (V599E). The aim subsequent study to provide recent information on involved, as well potential impact targeted therapies inhibit these...
Celiac disease is a multisystem disorder that triggered by the consumption of gluten in genetically predisposed people, particularly those who carry HLA-DQ2 and HLA-DQ8 alleles. Environmental factors certain epigenetic mechanisms play fundamental role manifestation disease. It has been shown gut microbiome can influence progression to some extent. presents with gastrointestinal extraintestinal symptoms complicate diagnosis. Classic include digestive disorders, while non-classic anemia,...
Breast cancer is one of the leading causes death among women, which implies an urgent need to explore further alternative therapeutic strategies than conventional surgery, chemotherapy, and radiotherapy treatments. Thus, prevention should be highlighted through early genetic screening, not only patients with clear risk factors but also general population in order discover predisposition intervene earlier. The current innovations are focused on improving such treatments by devising less...