A5028408994- Hepatitis C virus research
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- Mosquito-borne diseases and control
- Hepatitis B Virus Studies
- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Vibrio bacteria research studies
- Medicinal Plants and Bioactive Compounds
- Lung Cancer Research Studies
- Biochemical and Molecular Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Inflammatory Biomarkers in Disease Prognosis
- Immune responses and vaccinations
- Folate and B Vitamins Research
- Inhalation and Respiratory Drug Delivery
- Infectious Encephalopathies and Encephalitis
- Research on Leishmaniasis Studies
- COVID-19 Clinical Research Studies
- Renal and related cancers
- Vitamin D Research Studies
- Glycosylation and Glycoproteins Research
- SARS-CoV-2 detection and testing
- Drug Transport and Resistance Mechanisms
Shanxi Medical University
2023-2024
First Affiliated Hospital of Kunming Medical University
2024
Kunming Medical University
2024
National Vaccine and Serum Institute
2022-2024
Yangzhou University
2010-2022
Guangzhou University of Chinese Medicine
2021
Hubei University of Chinese Medicine
2021
Macau University of Science and Technology
2021
Rutgers New Jersey Medical School
2019
Rutgers, The State University of New Jersey
2019
The interaction between gut microbiota-derived metabolites and the body plays a significant role in occurrence development of cancer. Secondary bile acids (BAs) are important products produced from microbial fermentation primary BAs, mainly deoxycholic acid (DCA) lithocholic (LCA). In gut, they can influence structure communities. Several studies have demonstrated that secondary as signaling molecules, activate variety pathways. They inhibit apoptosis cancer cells, induce progression cell...
Background Gastric cancer represents a highly aggressive form of malignant tumor originating from the epithelial cells lining gastric mucosa. Despite notable improvements in treatment approaches over last few years, associated mortality rate continues to be considerably high. Therefore, there is pressing requirement for dependable biomarkers that can utilized predict and monitor prognosis, as well formulate targeted strategies patient groups at high risk. Methods We conducted an analysis...
Since the beginning of COVID-19 pandemic, numerous variants severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged, including five concern (VOC) strains listed by WHO: Alpha, Beta, Gamma, Delta and Omicron. Extensive studies shown that most these VOC strains, especially currently dominant variant Omicron, can escape host immune response induced existing vaccines to different extents, which poses considerable risk health human beings around world. In present study, we...
Gastric neuroendocrine carcinoma (GNENs), as a highly malignant gastrointestinal tumor, is characterized by easy postoperative metastasis, and its prognosis has always been poor compared to other tumors. Due rarity, there have few case reports studies on it. As of now, no clear diagnosis treatment sequence guidelines. In this report, we present GNENs that underwent first-line after surgery. The patient achieved an excellent survival combination chemotherapy resistance immunotherapy. This...
Abstract Background As one of the most malignant tumors digestive tract, gastric cancer has a high incidence rate and mortality in recent years, lacks significant prognostic indicators. D-dimer, as degradation product fibrin, is conventional biomarker for coagulation been studied to have potential promoting effects on postoperative patients. However, there are also contradictory results, with some studies reporting effect, while others not shown any effect. Therefore, actual impact D-dimer...
Gastric cancer, one of the most aggressive tumors affecting digestive tract, has seen a rise in both incidence and mortality rates recent years, with lack clear prognostic indicators. D‑dimer, byproduct fibrin degradation, is conventional coagulation biomarker that been investigated as potential adverse factor for postoperative cancer patients. However, conflicting results exist, some studies suggesting D‑dimer an independent risk prognosis gastric others there no significant association...
Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2019, virus has been mutating continuously, resulting continuous variants and creating challenges for epidemic prevention control. Here, we immunized mice with different vaccine candidates, revealing immune, protein, metabolomic changes that take place vaccines composed variants. We found prototype strain Delta- Omicron-variant inactivated candidates could all induce a high level neutralizing...
Abstract Background: Alzheimer's disease (AD) is the commonest neurodegenerative characterized with a progressive loss of cognitive functions and memory decline. Kai Xin San (KXS), traditional Chinese herbal classic prescription, has been used to ameliorate dysfunction for thousands years. However, its specific pharmacological molecular mechanisms have not fully clarified. Methods: The ingredients KXS their corresponding targets were firstly screened from ETCM database. AD-related target...
There are some concerns about the safety of live attenuated yellow fever vaccines (YF-live), particularly viscerotropic adverse events, which have a high mortality rate. The cellular production vaccine will not cause these effects and has potential to extend applicability those who allergic reactions, immunosuppression, age. In this study, inactivated (YF) was prepared adsorbed with Alum/CpG. humoral immunities were investigated in mouse model. results showed that Alum/CpG (20 μg/mL) could...