ring-array photoacoustic tomography (PAT) system has been widely used in noninvasive biomedical imaging. However, the reconstructed image usually suffers from spatially rotational blur and streak artifacts due to non-ideal imaging conditions. To improve towards higher quality, we propose a concept of convolution formulate process, then build regularized restoration problem model accordingly design an alternating minimization algorithm which is called blind deconvolution achieve restored...

A zinc-mediated cross-electrophile coupling of benzyl sulfonium salts with thiosulfonates via C-S bond cleavage was achieved. The reductive thiolation proceeded well under transition metal-free conditions to afford the desired sulfides in good yields, exhibiting both broad substrate scope and functionality tolerance. In addition, reaction could be applied use selenosulfonate as an effective selenylation agent subjected scale-up synthesis.

The concise and divergent total synthesis of (−)-indoxamycins A, C, F has been completed for the first time by using a tricyclic enone as common late-stage intermediate. key steps strategy are based on an Ireland–Claisen rearrangement, stereodivergent reductive 1,6-enyne cyclization, tandem 1,2-addition/oxa-Michael/methylenation reaction. As service to our authors readers, this journal provides supporting information supplied authors. Such materials peer reviewed may be re-organized online...

Abstract A non‐oxidant and metal‐free strategy for synthesizing iso‐coumarin by using a continuous electrochemical microreactor to initiate an oxidative cyclization reaction of o ‐(1‐alkynyl) benzoate radicals. This efficient clean electrosynthesis method not only avoids the complicated gas protection operation production by‐products in batch processes, but also help overcome difficulty that metal catalysis electrocatalysis are difficult scale up, has potential pilot‐scale experiment.

This study introduces a traceless linker strategy for pentadehydro-Diels–Alder (PDDA) cyclization, in which the sulfide/sulfone is strategically repurposed as diene surrogate. As excellent electron-donating dienes, these linkers react with electron-deficient alkenes and alkynes, resulting series of highly selective cyclization products. cascade reaction efficiently integrates PDDA transformation, formally eliminating need permanent structural constraints. By exploiting intrinsic reactivity...

Abstract A concise total synthesis of rac‐alsmaphorazine D has been described for the first time. The efficient synthetic strategy features four key transformations: 1) a catalytic intramolecular oxidative cyclization δ‐lactamindole backbone; 2) an cyclic aminal formation hexahydropyrrolo[2,3‐b]pyrrole framework; 3) transannular radical construction diazabicyclo[3.3.1]nonane structure; and 4) one‐pot desilylation/double epimerization reaction that affirms relative stereochemistry.

A concise and efficient approach for the diastereoselective total synthesis of salvileucalin C, as well their biosynthetically related diterpenoids D, salvipuberulin, isosalvipuberulin, dugesin B, has been reported first time. The key features strategy are based on a Beckwith-Dowd ring expansion, tandem Stille coupling/debromination/desilylation/lactonization reaction, photoinduced electrocyclic contraction.

Abstract In this study, a concise and stereoselective approach for the divergent total synthesis of (−)‐indoxamycins A–F is described. The key steps strategy include an Ireland–Claisen rearrangement, enantioselective 1,6‐enyne reductive cyclization, tandem 1,2‐addition/oxa‐Michael/methylenation reaction. relative absolute configuration these natural products has been unambiguously elucidated, their cytotoxic activities against HT‐29 A‐549 tumor cell lines are also reported.

Abstract A concise total synthesis of rac‐alsmaphorazine D has been described for the first time. The efficient synthetic strategy features four key transformations: 1) a catalytic intramolecular oxidative cyclization δ‐lactamindole backbone; 2) an cyclic aminal formation hexahydropyrrolo[2,3‐b]pyrrole framework; 3) transannular radical construction diazabicyclo[3.3.1]nonane structure; and 4) one‐pot desilylation/double epimerization reaction that affirms relative stereochemistry.

Eine effiziente und divergente Totalsynthese der (−)-Indoxamycine A, C F wurde durch die Verwendung eines tricyclischen Enons als gemeinsames spätes Intermediat ermöglicht. Die Schlüsselschritte Synthese sind eine Ireland-Claisen-Umlagerung, stereodivergente reduktive 1,6-Enin-Cyclisierung Tandemreaktion bestehend aus 1,2-Addition, Oxa-Michael-Reaktion Methylenierung. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials...

The hexadehydro-Diels–Alder (HDDA) reaction converts a 1,3-diyne bearing tethered alkyne (the diynophile) into bicyclic benzyne intermediates upon thermal activation. With only few exceptions, this unimolecular cycloisomerization requires, depending on the nature of atoms connecting diyne and diynophile, temperatures ca. 80–130 °C to achieve convenient half-life (e.g., 1–10 h) for reaction. In report, we divulge new variant HDDA process in which tether contains central, quaternized nitrogen...

Here we describe the use of hexadehydro-Diels–Alder (HDDA) reaction for de novo construction isoindolinone scaffold and its application to synthesis title natural products. The key isoindolinone-forming HDDA involved an unprecedented substrate motif in which amide carbonyl group was conjugated 4π 1,3-diyne component. In addition, a dimethylsilyl (−SiMe2H) substituent exploited trigger Fleming–Tamao–Kumada oxidation installation essential phenolic hydroxyl group.

Abstract A strategy for electrochemically synthesizing selenium benzoxazines through o ‐vinylaniline and diselenide has been developed. This metal‐free oxidant‐free electrochemical synthesis method is carried out in an undivided cell under mild conditions, which more environmentally friendly. Moreover, a variety of selenium‐substituted benzoxazine can be prepared good yield with broad scope functional group tolerance, potential industrial application value.

Indoxamycins A–F represent a novel class of polyketides isolated from saline cultures actinomycetes. Owing to their stereochemically congested tricyclic structure and potent biological activities, indoxamycins are attractive targets for synthetic chemists. This report discusses recent progress toward the total synthesis both by Carreira's group ours.

pH sensing is essential in various fields including healthcare, environmental monitoring, food safety, and agriculture. In this Letter, we propose a method for wide-range measurement based on the direct response of liquid crystal (LC) to variations via whispering gallery mode (WGM). The 4-cyano-4'-pentylbiphenyl (5CB) selected its excellent optoelectronic properties birefringence 5CB microdroplets serving as spherical resonators. This sensor achieves without any intermediaries. Polarized...

Abstract Review: [16 refs.

Abstract The preparation of salvileucalin C (I) and its biosynthetically related diterpenoids D (II), salvipuberulin (III), isosalvipuberulin (IV) dugesin B (V) is achieved.

Abstract Based on the total syntheses originally reported structures of target compounds are revised.

Abstract None of the compounds show significant cytotoxic activities against HT‐29 and A‐549 tumor cell lines.

Abstract An efficient synthesis of rivaroxaban has been accomplished by a sequence spanning five steps from 4‐morpholinoaniline and ( S )‐2‐(oxiran‐2‐ylmethyl)isoindoline‐1,3‐dione with an overall yield 44 %. This is concise, environmentally benign cost‐effective, providing good basis for the development new process rivaroxaban.

Lobotoside E is a potent growth inhibitor of various human tumor cell lines. The bayogenin derivative J was elaborated in series C-O bond-forming reactions (numbered sequence) to create the macrocycle.