A5078345975- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Pelvic floor disorders treatments
- Ovarian cancer diagnosis and treatment
- Porphyrin and Phthalocyanine Chemistry
- Medical and Health Sciences Research
- Pregnancy and preeclampsia studies
- Photoacoustic and Ultrasonic Imaging
- Pregnancy-related medical research
- Endometrial and Cervical Cancer Treatments
- Maternal and Perinatal Health Interventions
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Maternal and fetal healthcare
- Optical Imaging and Spectroscopy Techniques
- Preterm Birth and Chorioamnionitis
- Neonatal Respiratory Health Research
- Health and Medical Studies
- Urinary Bladder and Prostate Research
- Cancer and Skin Lesions
- Urinary Tract Infections Management
- Appendicitis Diagnosis and Management
- Breast Implant and Reconstruction
- Intestinal and Peritoneal Adhesions
- Nonmelanoma Skin Cancer Studies
University of St. Gallen
2012-2024
Kantonsspital St. Gallen
2014-2024
University Hospital of Zurich
1998-2024
University Hospital of Basel
2022
Olgahospital
2008-2021
Innsbruck Medical University
2020
Universität Innsbruck
2020
Kantonsspital Baden
2020
Allergiezentrum Wien West
2019
Universitäts Frauenklinik
2007-2018
Near infrared diffuse optical spectroscopy and imaging are promising methods that eventually may enhance or replace existing technologies for breast cancer screening diagnosis. These techniques based on highly sensitive, quantitative measurements of functional contrast between healthy diseased tissue. In this study, we examine whether changes in physiology caused by exogenous hormones, aging, fluctuations during the menstrual cycle result significant alterations tissue contrast. A...
Exposure to nanoparticles (NPs) in pregnancy is increasingly linked adverse effects on embryo-fetal development and health later life. However, the developmental toxicity mechanisms of NPs are largely unknown, particular potential placental secretome, which orchestrates many processes pivotal for success. This study demonstrates extensive material- stage-specific deregulation signaling from a single exposure human explants physiologically relevant concentrations engineered (silica (SiO
Abstract Background and Objectives To determine the feasibility of photodynamic therapy (PDT) vulvar vaginal condyloma intraepithelial neoplasia (VIN, VAIN) to compare PDT results with conventional treatments. Study Design/Materials Methods Thirty‐eight patients or (VIN) grade II/III (n = 22) 16) had 10% 5‐aminolevulinic acid (ALA)‐gel applied topically. After 2–4 hours, 80–125 J/cm 2 laser light at a wavelength 635 nm was applied. compared treatments for (CO evaporation) VIN III (laser...
The aims of this study were: (i) to quantify near-infrared optical properties normal cervical tissues and high-grade squamous intra-epithelial lesions (H-SIL); (ii) assess the feasibility differentiating from H-SIL on basis these properties; (iii) determine how tissue change following photodynamic therapy (PDT) in vivo. Using frequency domain photon migration technique, non-invasive measurements dysplastic ecto-cervical properties, i.e. absorption (μa) effective scattering coefficients,...
Chest wall recurrences are a frequent problem in patients treated by mastectomy for breast cancer. Surgery and ionizing radiation established treatment modalities these cases. Photodynamic therapy (PDT) provides an alternative modality using photosensitizer laser light to induce selective tumor necrosis. PDT was performed as compassionate use 7 aged 57.6 years (+/-12.6 SD). A total of 89 metastatic skin nodes were 11 sessions. As meta-tetra(hydroxyphenyl)chlorin (m-THPC) applied...
Abstract: Axillary lymph node dissection (ALND) is the standard of care for nodal staging patients with invasive breast cancer. Due to significant somatic and psychological side effects, replacement ALND less techniques desirable. The goal this study was evaluate clinical usefulness axillary (ALN) by means positron emission tomography (PET) 18F-fluorodeoxyglucose (FDG) in cancer qualifying sentinel biopsy (SLNB). FDG-PET performed within 1 week before surgery 24 clinically node-negative...
Benzoporphyrin-derivative (BPD)–monoacid-ring A photodynamic therapy (PDT) was performed on subcutaneous tumor implants in a rat ovarian cancer model. In order to assess PDT efficacy the and normal tissue optical properties were measured noninvasively prior during using frequency-domain photon migration (FDPM). FDPM data used quantify absorption reduced scattering (given by parameters μa μ′s, respectively) at four near-infrared (NIR) wavelengths (674, 811, 849 956 nm). Tissue physiologic...
Protocols for the prevention of infections after allogeneic or autologous hemopoietic stem cell transplantations are usual. A questionnaire was sent out to members European Group Bone and Marrow Transplantation (EBMT) in spring 1999. total 308 questionnaires from 180 centers were returned. Both transplantation reported 128 centers, alone four 48 respectively. Hemopoietic is still a domain university hospitals. Intensive measures isolation Allotransplantation commonly performed single rooms...
Abstract Objective The aim of this study was to investigate guidelines on preterm birth, analyze decision-criteria, and identify consensus discrepancies among these guidelines. Design analysis Sample Ten international birth. Methods Relevant decision criteria were singleton vs. twin pregnancy, history, cervical length, surgery / trauma or Mullerian anomaly. Eight treatment recommendations extracted. For each decision-making the most commonly recommended identified, level evaluated. Main...
Abstract Background Preeclampsia remains one of the most serious complications pregnancy. Effective therapies are yet to be developed. Recent research has identified an imbalance angiogenic and antiangiogenic factors as a root cause preeclampsia. In particular, soluble fms‐like tyrosine kinase‐1 (sFlt‐1) been shown bind vascular endothelial growth factor (VEGF) placental (PlGF), reducing blood vessel growth. Increasing preclinical clinical evidence suggests that removal sFlt‐1 protein may...
Photodynamic therapy (PDT) uses laser light to activate a photosensitizer that has been absorbed preferentially by cancer cells after systemic administration. A phototoxic reaction ensues resulting in cell death and tissue necrosis. Some cells, however, may survive PDT. This study was performed determine if surviving human breast (MCF-7) can become resistant PDT, chemotherapy or radiotherapy. The MCF-7 were cultured under standard conditions prior being exposed the photosensitizer,...