A5101597641- Signaling Pathways in Disease
- Genetics, Aging, and Longevity in Model Organisms
- Cellular Mechanics and Interactions
- Microtubule and mitosis dynamics
- Endoplasmic Reticulum Stress and Disease
- Ion channel regulation and function
- Autophagy in Disease and Therapy
- Dental materials and restorations
- Tissue Engineering and Regenerative Medicine
- Endodontics and Root Canal Treatments
- Connective tissue disorders research
- Cardiac electrophysiology and arrhythmias
- Protein Kinase Regulation and GTPase Signaling
- Insect and Arachnid Ecology and Behavior
- Toxin Mechanisms and Immunotoxins
- Cardiac Fibrosis and Remodeling
- Plant Reproductive Biology
- Cancer-related molecular mechanisms research
- Dental Erosion and Treatment
- Mesenchymal stem cell research
- Lipid metabolism and disorders
- Skin and Cellular Biology Research
- Osteoarthritis Treatment and Mechanisms
- Dental Implant Techniques and Outcomes
- Invertebrate Immune Response Mechanisms
Shaanxi Normal University
2017-2025
Zhongshan Hospital of Xiamen University
2021-2022
Xiamen Medical College
2021-2022
Indiana University School of Medicine
2002-2011
University of Maryland, Baltimore
2006-2011
Indiana University – Purdue University Indianapolis
2011
University of Baltimore
2011
University of Maryland, College Park
2011
Biotechnology Institute
2006-2010
University of Maryland Medical Center
2008
Calcium phosphate mediated transfection has been used for delivering DNA into mammalian cells in excess of 30 years due to its most low cost introducing recombinant culture cells. However, multiple factors affecting the transfect efficiency are commonly recognized meanwhile years, this approach on higher differentiated and non-tumor such as CHO C2C12 limits application research.In paper, we systematically evaluated possible rate approach. Two categories, calcium phosphate-DNA...
Background. FK506-binding proteins (FKBP) are immunophilins that interact with the immunosuppressive drugs FK506 and rapamycin. Several FKBP family members such as FKBP12, FKBP12.6, FKBP51 expressed in T cells. It has been speculated these FKBPs possibly redundant immunosuppressant-induced T-cell inactivation. To determine pharmacological relevance of multiple inactivation, we have investigated physiological responses FKBP12-deficient FKBP12.6-deficient mutant cells to agent FK506. Methods....
Hemicentins are recently described extracellular matrix (ECM) proteins with a single ortholog in C. elegans that assembles into discrete tracks constricting broad regions of epithelial cell contact adhesive and flexible line-shaped junctions. There two highly conserved hemicentin genes most vertebrate species; however, nothing is known about the function or distribution hemicentins. To determine hemicentins, we used polyclonal antibody to stain mouse tissue showed hemicentins found...
Prostate cancer (PrCa) progression and mortality are associated with calcium metabolism, parathyroid hormone level, vitamin D level. However, the lack of comprehensive understanding on molecular rationale intake, serum homeostasis, cytoplasmic function, is critically hindering our ability to propose a mechanism based technique for targeting in PrCa. Recently, studies performed PrCa samples have shown that calcium-sensing receptor regulates levels relation extracellular concentrations. Recent...
Macrophage accumulation within the vascular wall is a hallmark of atherosclerosis. Controlling macrophage conversion into foam cells remains major challenge for treatment atherosclerotic diseases. Here, we show that Wip1, member PP2C family Ser/Thr protein phosphatases, modulates migration and phagocytosis associated with plaque formation. Wip1 deficiency increases migratory phagocytic activities under stress conditions. Enhanced Wip1-/- macrophages mediated by Rac1-GTPase PI3K/AKT...
Fibulin-1C and fibulin-1D splice variants have been conserved throughout metazoan evolution distinct functions in Caenorhabditis elegans development. Both are required for the assembly of hemidesmosome-mediated mechanosensory neuron uterine attachments, although molecular associations that underlie their at these locations not known. Here, we show fibulin-1C anchorages is dependent upon components extracellular matrix (ECM): Fibulin-1D neurons attachments a perlecan/ UNC-52 variant includes...
FK506 binding protein12.6 (FKBP12.6) binds to the Ca2+ release channel ryanodine receptor (RyR2) in cardiomyocytes and stabilizes RyR2 prevent premature sarcoplasmic reticulum release. Previously, two different mouse strains deficient FKBP12.6 were reported have abnormal cardiac phenotypes. The first mutant strain displayed sex-dependent hypertrophy, while second exercise-induced arrhythmia sudden death. In this study, we tested whether FKBP12.6-deficient mice that display hypertrophic...
Liver hepatocellular carcinoma (LIHC) remains a global health challenge with poor prognosis and high mortality. FKBP1A was first discovered as receptor for the immunosuppressant drug FK506 in immune cells is critical various tumors cancers. However, relationships between expression, cellular distribution, tumor immunity, LIHC remain unclear. Here, we investigated expression level of its prognostic value via multiple datasets including ONCOMINE, TIMER, GEPIA, UALCAN, HCCDB, Kaplan-Meier...
The ryanodine receptor/Ca(2+) release channels from skeletal (RyR1) and cardiac (RyR2) muscle cells exhibit different inactivation profiles by cytosolic Ca(2+). D3 is one of the divergent regions between RyR1 (amino acids (aa) 1872-1923) RyR2 (aa 1852-1890) may contain putative binding site(s) for Ca(2+)-dependent RyR. To test this possibility, we have deleted region (DeltaD3-RyR1), residues 1038-3355 (Delta(1038-3355)-RyR2) inserted into Delta(1038-3355)-RyR2 to generate sD3-RyR2. formed...
Interactions between extracellular matrix (ECM) proteins and their transmembrane receptors mediate cytoskeletal reorganization corresponding changes in cell shape during migration, adhesion, differentiation polarization. Cytokinesis is the final step division as cells employ a contractile ring composed of actin myosin to partition one into two. Cells undergo dramatic process, creating new membrane forming an invagination called cleavage furrow. However, existing models cytokinesis include no...
Interactions between extracellular matrix (ECM) proteins and transmembrane receptors mediate changes in cell shape during migration, adhesion, differentiation polarization. Cytokinesis is the final step division as cells employ a contractile ring composed of actin myosin to partition one into two. During process, an invagination nascent membrane forms new space called cleavage furrow. Despite dramatic cytokinesis, existing models include no role for ECM. In recent paper, we show that...
Interactions between extracellular matrix (ECM) proteins and transmembrane receptors mediate changes in cell shape during migration, adhesion, differentiation polarization. Cytokinesis is the final step division as cells employ a contractile ring composed of actin myosin to partition one into two. During process, an invagination nascent membrane forms new space called cleavage furrow. Despite dramatic cytokinesis, existing models include no role for ECM. In recent paper, we show that...
During chick embryo development, the liquid crystals appear in more than 20 organs at certain developmental stages, and vanish early post-natal stage. In this study, we found a complex embryo, YS-J/I tunnel system, charge of transporting LCs CCVCs preserved from yolk sac into embryo. This transportation initiates connecting to central region/reservoir via main tunnel, spreads radically various parts digestive system sub-tunnels. Our data indicate that could be best form nutrition which is...