A5001731962- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Circadian rhythm and melatonin
- Plant and animal studies
- Cell Image Analysis Techniques
- Advanced Fluorescence Microscopy Techniques
- Animal Behavior and Reproduction
- Advanced Electron Microscopy Techniques and Applications
- Microtubule and mitosis dynamics
- Cellular Mechanics and Interactions
- Retinal Development and Disorders
- Visual perception and processing mechanisms
Allen Institute
2023-2024
Allen Institute for Brain Science
2023-2024
Howard Hughes Medical Institute
2021-2024
Janelia Research Campus
2021-2024
Champalimaud Foundation
2024
University of Vermont
2024
Color and polarization provide complementary information about the world are detected by specialized photoreceptors. However, downstream neural circuits that process these distinct modalities incompletely understood in any animal. Using electron microscopy, we have systematically reconstructed synaptic targets of photoreceptors to detect color skylight Drosophila, used light microscopy confirm many our findings. We identified known novel selective for different wavelengths or polarized...
Summary Many animals rely on vision to navigate through their environment. The pattern of changes in the visual scene induced by self-motion is optic flow 1 , which first estimated local patches directionally selective (DS) neurons 2–4 . But how should arrays DS neurons, each responsive motion a preferred direction at specific retinal position, be organized support robust decoding downstream circuits? Understanding this global organization challenging because it requires mapping fine,...
Abstract Flying insects exhibit remarkable navigational abilities controlled by their compact nervous systems. Optic flow , the pattern of changes in visual scene induced locomotion, is a crucial sensory cue for robust self-motion estimation, especially during rapid flight. Neurons that respond to specific, large-field optic patterns have been studied decades, primarily large flies, such as houseflies, blowflies, and hover flies. The best-known optic-flow sensitive neurons are tangential...
Flying insects exhibit remarkable navigational abilities controlled by their compact nervous systems. Optic flow , the pattern of changes in visual scene induced locomotion, is a crucial sensory cue for robust self-motion estimation, especially during rapid flight. Neurons that respond to specific, large-field optic patterns have been studied decades, primarily large flies, such as houseflies, blowflies, and hover flies. The best-known optic-flow sensitive neurons are tangential cells...
Flying insects exhibit remarkable navigational abilities controlled by their compact nervous systems. Optic flow , the pattern of changes in visual scene induced locomotion, is a crucial sensory cue for robust self-motion estimation, especially during rapid flight. Neurons that respond to specific, large-field optic patterns have been studied decades, primarily large flies, such as houseflies, blowflies, and hover flies. The best-known optic-flow sensitive neurons are tangential cells...
Abstract Progress in histological methods and microscope technology has enabled dense staining imaging of axons over large brain volumes, but tracing such volumes requires new computational tools for 3D reconstruction data acquired from serial sections. We have developed a pipeline automated volume assembly densely stained imaged sections, which leverages machine learning-based segmentation to enable stitching alignment with the axon traces themselves. validated this segmentation-driven...
Expansion microscopy and light sheet imaging enable fine-scale resolution of intracellular features that comprise neural circuits. Most current techniques visualize sparsely distributed across whole brains or densely within individual brain regions. Here, we dense distributions immunolabeled proteins early visual cortical areas in adult macaque monkeys. This process may be combined with multiphoton magnetic resonance to produce multimodal atlases large, gyrencephalic brains.
Abstract Color and polarization provide complementary information about the world are detected by specialized photoreceptors. However, downstream neural circuits that process these distinct modalities incompletely understood in any animal. Using electron microscopy, we have systematically reconstructed synaptic targets of photoreceptors to detect color skylight Drosophila , used light microscopy confirm many our findings. We identified known novel selective for different wavelengths or...