Nafi Aygün

ORCID: 0000-0003-4631-0533
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About
Contact & Profiles
Research Areas
  • Head and Neck Surgical Oncology
  • Medical Imaging Techniques and Applications
  • Head and Neck Cancer Studies
  • Cerebrospinal fluid and hydrocephalus
  • Radiation Dose and Imaging
  • Advanced X-ray and CT Imaging
  • Salivary Gland Tumors Diagnosis and Treatment
  • Spinal Fractures and Fixation Techniques
  • Sinusitis and nasal conditions
  • Medical Imaging and Analysis
  • Glioma Diagnosis and Treatment
  • Spine and Intervertebral Disc Pathology
  • Meningioma and schwannoma management
  • Intracranial Aneurysms: Treatment and Complications
  • Advanced MRI Techniques and Applications
  • Head and Neck Anomalies
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Fetal and Pediatric Neurological Disorders
  • Vascular Malformations Diagnosis and Treatment
  • Ear and Head Tumors
  • Cerebral Venous Sinus Thrombosis
  • Neurosurgical Procedures and Complications
  • Spinal Dysraphism and Malformations
  • Tumors and Oncological Cases
  • Cerebrovascular and Carotid Artery Diseases

Moffitt Cancer Center
2022-2025

Johns Hopkins Hospital
2008-2022

Johns Hopkins University
2013-2022

Johns Hopkins Medicine
2007-2022

Siemens Healthcare (United States)
2015

Carestream (United States)
2015

Uppsala University
2014

Hanover College
2014

Gendarmerie Nationale
2005

Cleveland Clinic
2002

In image-guided spine surgery, robust three-dimensional to two-dimensional (3D-2D) registration of preoperative computed tomography (CT) and intraoperative radiographs can be challenged by the image content mismatch associated with presence surgical instrumentation implants as well soft-tissue resection or deformation. This work investigates similarity metrics in 3D-2D offering improved robustness against mismatch, thereby improving performance reducing eliminating need for manual masking....

10.1088/0031-9155/61/8/3009 article EN Physics in Medicine and Biology 2016-03-18

To assess the safety of 1.5 T magnetic resonance imaging (MRI) in patients with cochlear implants (CIs) internal magnets.Retrospective review CI who underwent an MRI at Johns Hopkins.Sixteen a mean age 43 ± 22 years total clinically indicated MRI. Devices from 3 major manufactures were represented.Binding mold material and gauze was performed before Some also administered sedative. Intravenous gadolinium contrast used all but 1 patient.Patients assessed regard to ability complete MRI, size...

10.1097/mao.0b013e3181ec1d61 article EN Otology & Neurotology 2010-08-20

CT is the frontline imaging modality for diagnosis of acute traumatic brain injury (TBI), involving detection fresh blood in (contrast 30-50 HU, detail size down to 1 mm) a non-contrast-enhanced exam. A dedicated point-of-care system based on cone-beam (CBCT) could benefit early TBI and improve direction appropriate therapy. However, flat-panel detector (FPD) CBCT challenged by artifacts that degrade contrast resolution limit application soft-tissue imaging. We present evaluate fairly...

10.1088/0031-9155/60/4/1415 article EN Physics in Medicine and Biology 2015-01-22

<h3>Background</h3> Joubert syndrome is a clinically and genetically heterogeneous ciliopathy. Neuroimaging findings have not been systematically evaluated in large cohort of patients with correlation molecular genetic cause cognitive function. <h3>Methods</h3> Brain MRI 110 was included this study. A comprehensive evaluation brain studies for infratentorial supratentorial morphological abnormalities performed. Genetic identified by whole-exome sequencing, functions were assessed...

10.1136/jmedgenet-2016-104425 article EN Journal of Medical Genetics 2017-01-13

Background The benefit of immune checkpoint inhibitors (ICIs) in patients with leptomeningeal metastases (LMM) is unknown. Methods We undertook a phase II trial pembrolizumab LMM from solid tumors. Eligible had radiologic/cytologic and Eastern Cooperative Oncology Group performance status 0–1. Pembrolizumab was administered intravenously at 200 mg q3W until disease progression/unacceptable toxicity. primary endpoint central nervous system (CNS) response after four cycles, defined...

10.1136/jitc-2021-002473 article EN cc-by-nc Journal for ImmunoTherapy of Cancer 2021-08-01

Abstract Objective 18F‐Fluorodeoxyglucose positron emission tomography (FDG‐PET) is widely used in presurgical assessment patients with drug‐resistant focal epilepsy (DRE) if magnetic resonance imaging (MRI) and scalp electroencephalography (EEG) do not localize the seizure onset zone or are discordant. Methods In this multicenter, retrospective observational cohort study, we included consecutive DRE who had undergone FDG‐PET as part of their workup. We assessed utility FDG‐PET, which was...

10.1111/epi.17194 article EN cc-by-nc-nd Epilepsia 2022-02-15

<h3>Objective</h3>To determine the value of positron emission tomography (PET) with contrast-enhanced computed (CT) in assessing need for neck dissection by retrospectively reviewing pathology reports patients human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (SCC).<h3>Design</h3>Retrospective cohort study.<h3>Setting</h3>Tertiary medical center.<h3>Patients</h3>Seventy-seven HPV-related SCC.<h3>Main Outcome Measures</h3>Seventy-seven consecutive a diagnosis SCC who...

10.1001/jamaoto.2013.607 article EN cc-by Archives of Otolaryngology - Head and Neck Surgery 2012-11-01
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