Journal Article THE "YELLOW NAIL" SYNDROME. Get access PETER D. SAMMAN, M.D., F.R.C.P., F.R.C.P. Physician for Diseases of the Skin, Westminister Hospital, London, S.W.I amt The Institute Dermatology, St. John's Hospital. Lisle Street, W.C.2; Senior Registrar, Radiotherapy Department. Westminster Search other works by this author on: Oxford Academic Google Scholar WILLIAM F. WHITE, M.B., B.S., D.M.R.T. British Volume 76, Issue 4, 1 April 1964, Pages 153–157,...

Muscarinic cholinergic activity in the human arcuate nucleus at ventral medullary surface is postulated to be involved cardiopulmonary control. A significant decrease [ 3 H]quinuclidinyl benzilate binding muscarinic receptors now shown occur sudden infant death syndrome (SIDS) infants, compared infants dying acutely of known causes. In with chronic oxygenation abnormalities, low other nuclei, as well nucleus. The deficit SIDS might contribute a failure responses challenges during sleep.

The sudden infant death syndrome (SIDS) is postulated to result from a failure of homeostatic responses life-threatening challenges (e.g. asphyxia, hypercapnia) during sleep. ventral medulla participates in sleep-related responses, including chemoreception, arousal, airway reflex control, thermoregulation, respiratory drive, and blood pressure regulation, part via serotonin its receptors. humans contains the arcuate nucleus, which we have shown isolated defects muscarinic kainate receptor...

1. Brain synaptosomal fractions released both endogenous and exogenously loaded noradrenaline gamma‐aminobutyric acid (GABA) in response to calcium. Elevation of magnesium concentrations the release media decreased calcium‐dependent release. 2. The GABA occurred within 250 msec following application Following initial calcium, progressively with continued declined more rapidly than release, consistent a distribution having greater accessibility process. 3. Sodium was required for loading into...

Abstract— Glutamate and aspartate probably serve as transmitters of hippocampal perforant path commissural afferents, respectively. We therefore used slices regions to evaluate certain biochemical properties markers for sites transmission mediated by these amino acids. In studies content accumulation glutamate were compared with their Ca 2+ ‐dependent effluxes. Hippocampal varied little in contents aspartate, but regio superior dentate gyrus accumulated released more each than inferior. A...

The disappearance of methotrexate (MTX) from the serum after an intravenous bolus injection and infusion was studied over 24 hours in eight four patients respectively. Probenecid given at same time as delayed MTX resulted enhanced concentrations throughout studied. At mean concentration times higher than not probenecid. Overall were even greater those who had received by infusion. We suggest that smaller doses may be treatment costs thereby reduced if probenecid is addition.

Abstract— Superfused slices of the rat dentate gyrus were employed to study release GABA, glutamate and aspartate, which are considered strong neurotransmitter candidates in this region. The introduction Ca 2+ a ‐free superfusion medium containing depolarizing agent augmented efflux all three amino acids. response application nearly always occurred within 30 s, shortest interval tested these studies. rate reached peak 90 s then declined level slightly greater than prestimulation baseline....

The human arcuate nucleus is postulated to be homologous ventral medullary surface cells in animals that participate ventilatory and blood pressure responses hypercarbia asphyxia. Recently, we reported a significant decrease muscarinic cholinergic receptor binding the victims of sudden infant death syndrome compared with control patients died acute causes. To test specificity deficit binding, examined kainate same database. We assessed 3H-kainate receptors tissue autoradiography 17 brainstem...

Journal Article A frameshift mutation in the mouse α1 glycine receptor gene (Gira1) results progressive neurological symptoms and juvenile death Get access Marion S. Buckwalter, Buckwalter Search for other works by this author on: Oxford Academic PubMed Google Scholar Susan A. Cook, Cook 1The Jackson Laboratory, Bar Harbor, ME 04609 Muriel T. Davisson, Davisson W. Frost White, White 2Department of Neuroscience, Pfizer Central Research, Easton Point Road, Groton, CT 06340, USA Sally Camper *...

Maternal cigarette smoking during pregnancy has been shown to be a major risk factor for the sudden infant death syndrome (SIDS). We hypothesized that SIDS is associated with altered 3H-nicotine binding nicotinic receptors in brainstem nuclei related cardiorespiratory control and/or arousal. analyzed 14 regions and brainstems using quantitative tissue receptor autoradiography. Three groups were analyzed: (n = 42), acute controls 15), chronic group oxygenation disorders 18). The arcuate...

The regional distributions of muscarinic receptor subtypes (M1 and M2) in the macaque brain were investigated by vitro autoradiography. Putative distinguished their differential affinities for pirenzepine carbachol competition with [3H]-quinuclidinyl benzilate. Autoradiographic visualization demonstrated marked laminar variations that respected architectonic boundaries. M1 subtype was widely distributed throughout most cortical areas intense over superficial layers. Almost all limbic...

Long-term administration of [D-Leu6, des-Gly-NH210, Pro-ethylamide9]-GnRH, an analog gonadotropin releasing hormone, caused regression neoplastic tissue in a rat bearing spontaneous mammary adenocarcinoma and rats which tumors had been induced by treatment with dimethylbenzanthracene (DMBA). During two separate periods the analog, tumor single animal regressed although it previously grown spontaneously. After third period growth, ovariectomy also regression, suggesting endocrine dependency...

The present study evaluated the effects of two novel N-methyl-d-aspartate (NMDA) receptor blockers and ifenprodil derivatives, CP-101,606 CP-101,581, their racemic mixture CP-98,113, on spatial memory regional cerebral edema following experimental fluid-percussion (FP) brain injury in rat (n = 66). Fifteen minutes after (2.5 atm), animals received either (1) CP-98,113 (5 mg/kg, i.p., n 11), (2) CP-101,581 13), (3) (6.5 12), or (4) DMSO vehicle (equal volume, 12); followed by a continuous...