A5007238903- Listeria monocytogenes in Food Safety
- Essential Oils and Antimicrobial Activity
- Cancer therapeutics and mechanisms
- Food Safety and Hygiene
- Salmonella and Campylobacter epidemiology
- Antibiotic Resistance in Bacteria
- Vibrio bacteria research studies
- Bioactive Compounds and Antitumor Agents
- Microbial Inactivation Methods
- Bacterial biofilms and quorum sensing
- Bacterial Identification and Susceptibility Testing
- Nanocomposite Films for Food Packaging
- Aquaculture disease management and microbiota
- Identification and Quantification in Food
- Antibiotics Pharmacokinetics and Efficacy
- Bioactive Natural Diterpenoids Research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Antimicrobial Resistance in Staphylococcus
- Phytochemicals and Antioxidant Activities
- Postharvest Quality and Shelf Life Management
- Bacteriophages and microbial interactions
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- RNA modifications and cancer
- Advanced Cellulose Research Studies
University of Helsinki
2017-2025
Plant & Food Research
2012-2024
Universidade de São Paulo
2007-2009
Instituto de Ciências Farmacêuticas
2008
Drexel University
1994
Biofilms are formed by a complex bacterial community encapsulated polymeric matrix, with strong adherent properties and persistent phenotype. considered one of the most challenging areas modern medicine. Existing antibiotics have been developed against free-floating cells, thus, many treatments biofilm-related infection fail. In this study, we compared effects different media on biofilm growth clinical reference strains Staphylococci Enterococci, including multi-drug resistant...
The shelf life of fresh fish and meat transported over long distances could be extended by using plant-based extracts to control spoilage bacteria. goals the present study were identify that effectively suppress main bacteria chilled lamb assess their antioxidant capacity. phenolic compounds in wood-based tannins isolated from byproducts fruit processing industry identified and/or quantified. total phenol content, but not flavonoid ratio, was strongly associated with higher antibacterial...
A series of quaternary ammonium fluoroquinolones was obtained by exhaustive methylation the amine groups present at 7-position fluoroquinolones, including ciprofloxacin, enoxacin, gatifloxacin, lomefloxacin, and norfloxacin. The synthesized molecules were tested for their antibacterial antibiofilm activities against Gram-positive Gram-negative human pathogens, i.e. Staphylococcus aureus Pseudomonas aeruginosa. study showed that compounds are potent agents (MIC values lowest 6.25 μM) with low...
ABSTRACT The food-borne pathogen Vibrio parahaemolyticus has been reported as being present in New Zealand (NZ) seawaters, but there have no outbreaks of infection from commercially grown NZ seafood. Our study determined the current incidence V. oysters and Greenshell mussels prevalence tdh trh strains. Pacific (235) dredge (21) oyster samples mussel (55) were obtained commercial shellfish-growing areas between December 2009 June 2012. Total numbers presence pathogenic genes using FDA...
We designed and synthesized a series of inhibitors the bacterial enzymes DNA gyrase topoisomerase IV, based on our recently published benzothiazole-based inhibitor bearing an oxalyl moiety. To improve antibacterial activity retain potent enzymatic activity, we systematically explored chemical space. Several strategies modification were followed: varying substituents pyrrole carboxamide moiety, alteration central scaffold, including variation substitution position and, most importantly,...
Abstract Global antimicrobial resistance poses a major threat to human health and is largely driven by bacterial biofilms, which demonstrate significantly greater antibiotic than planktonic bacteria. While most biofilm research targets the development of antibiofilm surfaces, materials that intentionally promote formation are crucial for creating screening tools discover new agents. The transition from static flow‐through assay systems also necessary increase methodological readiness...
The outer membrane factor TolC is an essential component of various efflux pump complexes in E. coli and represents a potential target for antibiotic adjuvants. By means virtual screen TolC-binding compounds, we identified the kinase inhibitor CEP-37440 to shift minimum inhibitory concentration antibiotics piperacillin levofloxacin coli. To determine substructure relevant binding, hit deconstruction approach was applied, resulting fragment-like compound with low affinity AcrB (LP-115)....
Tree stems contain wood in addition to 10–20% bark, which remains one of the largest underutilized biomasses on earth. Unique macromolecules (like lignin, suberin, pectin, and tannin), extractives, sclerenchyma fibers form main part bark. Here, we perform detailed investigation antibacterial antibiofilm properties bark-derived fiber bundles discuss their potential application as wound dressing for treatment infected chronic wounds. We show that yarns containing at least 50% willow bark...
Potent DNA gyrase and topoisomerase IV inhibitor bearing a siderophore mimic moiety displays improved antibacterial activity against Escherichia coli under iron-depleted conditions.
Listeriosis is caused by the food-borne pathogen Listeria monocytogenes, which can be found in seafood and processing plants. To evaluate risk to human health associated with production New Zealand, multi-virulence-locus sequence typing (MVLST) was used define types (STs) of 31 L. monocytogenes isolates collected from seafood-processing plants, 15 processed foods, 6 listeriosis cases. The STs these were then compared those a collection epidemic strains overseas. A total 17 Zealand clustered...
Increased Gram-negative bacteria resistance to antibiotics is becoming a global problem, and new classes of with novel mechanisms action are required. The caseinolytic protease subunit P (ClpP) serine conserved among that considered as an interesting drug target. ClpP function involved in protein turnover homeostasis, stress response, virulence other processes. focus this study was identify inhibitors Escherichia coli understand their mode action. A focused library based on diaryl...