A5063746988- Renal Diseases and Glomerulopathies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Vasculitis and related conditions
- Potassium and Related Disorders
- Pancreatitis Pathology and Treatment
- Renal and Vascular Pathologies
- Inflammatory Myopathies and Dermatomyositis
- Parathyroid Disorders and Treatments
- Complement system in diseases
- Hormonal Regulation and Hypertension
- Eosinophilic Disorders and Syndromes
- Birth, Development, and Health
- Nephrotoxicity and Medicinal Plants
- Pulmonary Hypertension Research and Treatments
- Parvovirus B19 Infection Studies
- Prostate Cancer Treatment and Research
- Liver Disease Diagnosis and Treatment
- Inflammasome and immune disorders
- Systemic Lupus Erythematosus Research
- Adenosine and Purinergic Signaling
- Vascular Anomalies and Treatments
- IgG4-Related and Inflammatory Diseases
- Renal Transplantation Outcomes and Treatments
- Adrenal and Paraganglionic Tumors
- Traumatic Brain Injury and Neurovascular Disturbances
Pontificia Universidad Católica de Chile
2013-2023
Universidad de la República
2012-2015
Hospital de Clínicas
2015
Universidad Politécnica de Madrid
2011
Brigham and Women's Hospital
2006-2011
Harvard University
2006-2011
University of Massachusetts Amherst
2005
Virginia Commonwealth University Medical Center
1981
To determine whether mineralocorticoid receptor (MR) activation plays a role in diabetic renal injury and this differs types 1 2 diabetes mellitus, we examined the effect of MR antagonist on rodent models type (streptozotocin-treated rat) (db/db mouse) diabetes. We studied three groups 8-wk-old, uninephrectomized Wistar rats for 4 wk: streptozotocin- (55 mg/kg) treated (n = 11), streptozotocin-treated receiving eplerenone 15), nondiabetic 9). In addition, 8-wk-old mice 16 db/db 10), with 8),...
Pathologic changes in nonneoplastic renal parenchyma of nephrectomy specimens for tumors and the significance these with regard to outcome contralateral kidney function have not been studied previously. We examined parenchymal 110 consecutive tumor specimens, we correlated our findings patients' clinical information. The material was presence any glomerular, tubulointerstitial, or vascular pathology. In analysis, only about 10% cases had unremarkable vasculature. A further 28% parenchyma,...
Acute interstitial nephritis is commonly seen in kidney biopsies of patients with acute renal failure; however, granulomatous (GIN) rare. We identified 46 cases GIN a 17-year period this institution and we investigated their most probable etiologies. Complete clinical information was available 38 patients. Seventeen (44.7%) were classified as drug-induced. Renal sarcoidosis responsible for 28.9% cases, the remaining 15.9% included Wegeners granulomatosis, foreign body giant cell reaction,...
Human metapneumovirus (hMPV) is a leading cause of acute respiratory tract infections in children and the elderly. The mechanism by which this virus triggers an inflammatory response still remains unknown. Here, we evaluated whether thymic stromal lymphopoietin (TSLP) pathway contributes to lung inflammation upon hMPV infection. We found that infection promotes TSLP expression both human airway epithelial cells mouse lung. induced infiltration OX40L(+) CD11b(+) DCs. Mice lacking receptor...
Systemic lupus erythematosus is characterized by the presence of circulating anti-nuclear antibodies (ANA) and systemic damage that includes nephritis, haematological manifestations pulmonary compromise, among others. Although major progress has been made in elucidating molecular mechanisms responsible for autoimmunity, current therapies have not improved considerably. Because exposure carbon monoxide (CO) shown to display beneficial immunoregulatory properties different immune-mediated...
Lysinuric protein intolerance (LPI) is an inborn error of metabolism caused by defective transport cationic amino acids in epithelial cells intestines, kidneys and other tissues as well non-epithelial including macrophages. LPI biallelic, pathogenic variants
The association of granulomatous lobular mastitis and carcinoma the breast is very infrequent. We present case a 44-year-old woman with concurrent coryneform bacteria ductal in situ same breast.
Lupus nephritis (LN) is one of the most serious manifestations systemic lupus erythematosus (SLE). Based on studies showing potential role heme oxygenase-1 (HO-1), an enzyme that catalyzes degradation and has anti-inflammatory properties in SLE development, we decided to explore HO-1 LN. Accordingly, evaluated levels function circulating infiltrating monocytes neutrophils LN patients. were assessed peripheral patients controls by flow cytometry immunofluorescence microscopy. Phagocytosis...
Acute kidney injury (AKI), characterized by a sudden decline in function involving tubular damage and epithelial cell death, can lead to progressive tissue fibrosis chronic disease due interstitial fibroblast activation repair failures that lack direct treatments. After an AKI episode, surviving renal cells undergo cycles of dedifferentiation, proliferation redifferentiation while activity increases then declines avoid exaggerated extracellular matrix deposition. Appropriate recovery versus...
Granulomatous lobular mastitis is a rare disease whose origin still unknown and shows an increase in its frequency. Morphological, microbiological, molecular biology studies have linked this to lipophilic fastidious corynebacteria, suggesting possible infectious etiology. This series describes reviews detail the distinctive morphological characteristics of bacteria present granulomas disease, usefulness histochemical techniques for their identification, our proposal tissue quantification...
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used by patients all over the world. Five to eighteen percent of who receive NSAIDs can suffer from kidney-related side effects. Among them, most relevant sodium and water retention, hyponatremia, worsening hypertension or preexisting cardiac failure, hyperkalemia, acute kidney injury, chronic disease, papillary necrosis, nephrotic syndrome (NS), interstitial nephritis. We report case a 65-year-old woman developed tubular necrosis NS...
This study presents a case of juxtaglomerular cell tumor (JCT) in 12-year-old girl with hypertension. Fine needle aspirate (FNA) cytology demonstrated neoplasm features papillary carcinoma, prompting right radical nephrectomy. Histological examination revealed solid sheets round epithelioid cells eosinophilic granular cytoplasm, and distinct borders background widespread hemorrhage. Electron microscopy cytoplasmic renin granules. The differential diagnosis renal mass young patient...
Flutamide is a first-generation nonsteroidal antiandrogen, used for treatment of advanced prostate cancer (PCa). We present the clinical case patient with localized high-risk PCa who started flutamide before radical prostatectomy and evolved acute liver failure transplantation. Hepatotoxicity induced by antiandrogen therapy, current indications first generation anti-androgen therapy were reviewed. To our knowledge, this report man diagnosed secondary to flutamide, finally required
Latin American reports on pheochromocytomas and paragangliomas (PPGLs) are scarce. Recent studies demonstrate changes in clinical presentation management of these patients. Herein, we assessed the main characteristics PPGL patients our academic center over past 4 decades.Demographic, clinical, biochemical, perioperative data from 105 were retrospectively prospectively collected 1980-2019 period. Data organized into periods by decade.Age at diagnosis, gender, tumor size percentage...
Monoclonal gammopathy of renal significance (MGRS)-related lesions are infrequent entities. There no publications on these disorders in Latin America (LA). The aim this study was to describe epidemiological and clinical characteristics patients LA.We performed a multicentre retrospective study. Patients with diagnosis MGRS between 2012 2018 were included. Epidemiological data collected from records.Twenty-seven Chile, Argentina, Ecuador Uruguay Half debuted nephrotic syndrome, 32% required...
We report a 23 year old woman presenting with nephrotic syndrome due to minimal change disease, central diabetes insipidus, primary hypothyroidism, vitiligo and universal alopecia. Eleven years later, she presented secondary amenorrhea hypogonadotropic hypogonadism, mild hyperprolactinemia adrenal insufficiency. A magnetic resonance imaging of the sella turcica showed pituitary mass suprasellar extension that was resected using transsphenoidal approach. Pathology confirmed presence...
Rosai-Dorfman-Destombes disease (RDD) or sinus histiocytosis with massive lymphadenopathy (SHML), is a rare disorder, first described by Destombes in 1965 and then Rosai Dorfman reported the clinical series 1969. The etiology of RDD unknown, treatment not standardized. There no data about true number cases that exist worldwide. This occurs mainly children young adults, however, it may occur at any age. It more common males individuals African descent. RDD, presents clinically as painful...