A5076685040- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- Influenza Virus Research Studies
- Vaccine Coverage and Hesitancy
- IL-33, ST2, and ILC Pathways
- Dermatology and Skin Diseases
- Genomics, phytochemicals, and oxidative stress
- T-cell and B-cell Immunology
- Pharmacological Effects of Natural Compounds
- Hops Chemistry and Applications
- Toxic Organic Pollutants Impact
- Asthma and respiratory diseases
- Circadian rhythm and melatonin
- Exercise and Physiological Responses
- Fatty Acid Research and Health
- GDF15 and Related Biomarkers
- Chromatography in Natural Products
- Folate and B Vitamins Research
- Respiratory viral infections research
- Gut microbiota and health
Malaghan Institute of Medical Research
2021-2025
There is very little known about SARS-CoV-2 vaccine immune responses in New Zealand populations at greatest risk for serious COVID-19 disease. This prospective cohort study assessed immunogenicity BNT162b2 mRNA recipients without previous COVID-19, with enrichment Māori, Pacific peoples, older adults ≥ 65 years of age, and those co-morbidities. Serum samples were analysed baseline 28 days after second dose presence quantitative anti-S IgG by chemiluminescent microparticle immunoassay...
Mucosal-associated invariant T (MAIT) cells are unconventional which recognize microbial metabolites presented by the major histocompatibility complex class I-related molecule MR1. Although MAIT have been shown to reside in human and murine skin, their contribution atopic dermatitis (AD), an inflammatory skin disease associated with barrier dysfunction translocation, has not yet determined.Genetic deletion of MR1 topical treatment inhibitory ligands, result absence functional inhibition...
Influenza vaccination is an effective public health measure to reduce the risk of influenza illness, particularly when vaccine well matched circulating strains. Notwithstanding, efficacy varies greatly among vaccinees due largely unknown immunological determinants, thereby dampening population-wide protection. Here, we report that dietary fibre may play a significant role in humoral responses. We found intake and abundance fibre-fermenting intestinal bacteria be positively correlated with...
Diets high in fruit and vegetables are perceived to be beneficial for intestinal homeostasis, health as well the context of inflammatory bowel diseases (IBDs). Recent breakthroughs field immunology have highlighted importance ligand-activated transcription factor aryl hydrocarbon receptor (AhR) a critical regulator mucosal immunity, including trafficking CD4+ helper T cells, an immune cell subset implicated wide range homeostatic pathogenic processes. Specifically, AhR has been shown...
The ligand-activated aryl hydrocarbon receptor (AhR) is an important molecular regulator of immune function, whose activity can be modulated by dietary glucosinolate- and tryptophan-derived metabolites. In contrast, the potential use polyphenols as regulators AhR-dependent immunity remains unclear. this perspective, we discuss how cellular metabolism may alter net effect on AhR, thus potentially reconciling some conflicting observations reported in literature. We further provide a...
The ability of a third dose the Pfizer-BioNTech BNT162b2 SARS-CoV-2 vaccine to stimulate immune responses against subvariants, including Omicron BA.1, has not been assessed in New Zealand populations. Unlike many overseas populations, Zealanders were largely infection naïve at time they boosted. This adult cohort 298 participants, oversampled for at-risk was composed 29% Māori and 28% Pacific peoples, with 40% population aged 55+. A significant proportion obese presented least one...
Atopic dermatitis (AD) is a debilitating disease that disproportionately affects infants and young children considered the first step of atopic march—the age-related progression allergic disease. Consequently, there an urgent unmet need to elucidate root causes AD evaluate potential prevention mechanisms.
Abstract Background There is very little known about SARS-CoV-2 vaccine immune responses in New Zealand populations at greatest risk for serious COVID-19 disease. Methods This prospective cohort study assessed immunogenicity BNT162b2 mRNA recipients without previous COVID-19, with enrichment Māori, Pacific peoples, older adults ≥ 65 years of age, and those co-morbidities. Serum samples were analysed baseline 28 days after second dose presence quantitative anti-S IgG by chemiluminescent...
Abstract The ability of a third dose the Pfizer-BioNTech BNT162b2 SARS-CoV-2 vaccine to stimulate immune responses against subvariants, including Omicron BA.1, has not been assessed in New Zealand populations. Unlike many overseas populations, Zealanders were largely infection naïve at time they boosted. This adult cohort 298 participants, oversampled for at-risk was composed 29% Māori and 28% Pacific peoples, with 40% population aged 55+. A significant proportion obese presented least one...