Exosomal microRNAs (miRNAs) are reliable and noninvasive biomarkers for the early diagnosis of cancer. Yet, accurate feasible detection exosomal miRNAs is often hampered by low abundance in exosomes requirement RNA extraction large sample volumes. Here we show a thermophoretic sensor implemented with nanoflares situ miRNAs, without resorting to either or target amplification. Thermophoretic accumulation nanoflare-treated leads an amplified fluorescence signal upon binding nanoflares,...

Using natural membranes to coat nanoparticles (NPs) provides an efficient means reduce the immune clearance of NPs and improve their tumor-specific targeting. However, fabrication these drug-loaded biomimetic NPs, such as exosome membrane (EM)- or cancer cell (CCM)-coated poly(lactic-co-glycolic acid) (PLGA) remains a challenging task owing heterogeneous nature biomembranes labor-intensive procedures. Herein, we report microfluidic sonication approach produce EM-, CCM-, lipid-coated PLGA...

Microfluidic technologies with precise fluid control and rapid microscale mixing have attracted widespread interest in the fabrication engineering of nanomaterials for drug delivery. The drug-loaded prepared by microfluidic methods can exhibit better monodispersity, higher encapsulation efficiency, prolonged blood circulation time as compared to those conventional bench methods. In this review, we summarize recent advances a variety nanomaterials, including organic, inorganic, hybrid...

A novel, synthetically straightforward, selective DMAP‐promoted [4 + 2]/[3 3] annulation domino reaction of o‐acylamino‐aryl Morita−Baylis−Hillman (MBH) carbonates with α,β‐unsaturated imines to construct complex fused [2,7]naphthyridine frameworks has been developed. The provides a step‐economic strategy for the direct synthesis functionalized benzo[c][2,7]naphthyridines containing three stereogenic centers in high yields excellent chemo‐, regio‐, and diastereoselectivity under mild...

Abstract The endosymbiont Wolbachia has been detected in a few parthenogenetic collembolans sampled Europe and America, including three species of Poduromorpha, two Entomobryomorpha, Neelipleona. Based on 16S rRNA ftsZ gene sequences, most the infecting were characterized as members supergroup E showed concordant phylogeny with their hosts. However, neelipleonan symbionts form another unique group, indicating that infected multiple times. In this study, five collembolan identified hosts ,...

Abstract The study aims to search for green, non-toxic bio-based plasticizers replace traditional o-benzene petroleum-based used in polyvinyl chloride films automotive interior decoration. Three – epoxy, polyester, and citrate were chosen characterized based on refractive index, viscosity, plasticizing efficiency. three types of then applied PVC interiors. odor rating, emission properties test, tensile dynamic thermomechanical low-temperature fatigue resistance heat performance test...

Nucleotide-binding oligomerization domain-like receptors (NLRs) are intracellular sensors of pathogen-associated molecular patterns (PAMPs) and damage-associated (DAMPs). Previously, we reported nucleotide-binding domain-containing protein 1 (NOD1) antagonists (11, 12) a NOD2 antagonist (9) that sensitized docetaxel (DTX) or paclitaxel (PTX) treatment for breast lung cancer. In this article, describe the first time 1,4-benzodiazepine-2,5-dione (BZD) derivative (26bh) acts as dual NOD1/NOD2...

A coordinating, copper-catalyzed direct α-C(sp3)–H fluorination method has been developed to prepare vital quaternary α-fluorinated α-amino acid derivatives. Cu(II) catalytic SET oxidative addition mechanism is proposed, involving a key fluoride-coupled charge transfer complex. The protocol can tolerate rich variety of acids, for which the auxiliary group removed in high yield and substituted preparation dipeptide derivatives with detachable, single absolute configurations target compounds.

Herein a simple, catalyst- and solvent-free system for highly atom-economic synthesis of phthalazinones has been developed using phthalaldehydic acid, 2-acyl-benzoic substituted hydrazine as simple substrates. The reaction time was shortened to 20–60 min. Structurally diverse acids, hydrazines were transformed into with nearly 100% yield regardless the aggregate state electronic nature substituents. transformation demonstrated be amenable scale-up multiple liquid solid materials. In...

[reaction: see text] A solid-phase synthesis of trisubstituted 3-alkylamino-1,2,4-triazoles has been developed. The utilizes immobilized N-acyl-1H-benzotriazole-1-carboximidamides as key intermediates. Cyclization with hydrazines under mild conditions furnishes the title compounds regioselectivity and high purity.

A copper-catalyzed C(sp3)–H alkoxylation was developed to prepare quaternary α-alkoxylated amino acid derivatives in good yields. This protocol can be applied a series of α-amino acids bearing variety functional group substituents. Facile removal the auxiliary directing and tolerance condensation conditions for amide bond formation enable potential application this method discovery new peptide drugs future.

A switchable chemo-divergent strategy for γ-amino acid and γ-lactam preparation via intramolecular γ C–H amination of carboxylic acids.

Catechols react chemoselectively, in the presence of either alcohols, 1,2-diols, or simple phenols, with tert-butyl propynoate and methyl to give 2-Boc-ethylidene (Bocdene) 2-Moc-ethylidene (Mocdene) acetals, respectively, 96−100% yields within 30 min at room temperature, provided that 150 mol % DMAP is added. Cleavage these acetals pyrrolidine readily takes place (at temperature!) 95−100% yields. By taking advantage features Bocdene novel catecholamine-related phosphate mimetics have been prepared.

In this paper, we report very general conditions that enable palladium-mediated coupling reactions on the solid support. A wide variety of biaryls and arylamines (including pyrimidines) have been synthesized using protocol. The chemistry facilitates a combinatorial approach to production large numbers medicinally relevant heterocyclic structures.

Abstract In this work, three plasticizers with different molecular structures were used to plasticize poly(vinyl chloride) (PVC), and the influence of on flexural fatigue properties soft PVC was investigated. The plasticizer best plasticizing effect selected, five gradient dosages set study optimal ratio PVC. It found that glass transition temperature samples two phthalate (DPHP, 1012P) lower than trimellitate (TM‐8). has excellent low‐temperature mechanical great resistance. From comparison...

The genus Paracerella Imadaté, 1980 is recorded from China for the first time, with description of a new species, sinensis sp. n. characterized by four pairs A-setae on tergite I, presence setae Pc and P3a VII, eight VIII, seta both sternites VI 4/2 sternite which are different all other members genus. key to species updated. In addition, DNA barcodes populations sequenced their genetic differences analyzed.