New pyranocoumarin and coumarin-sulfonamide derivatives were prepared evaluated for their antioxidant, antimicrobial, and/or anti-inflammatory activities. Coumarin-sulfonamide compounds 8a-d demonstrated significant antioxidant activity, while 7c,d, 8c,d, 9c,d exhibited antimicrobial activity equal to or higher than the standard antimicrobials against at least one tested microorganism. Regarding testing, pyranocoumarins 2b, 3a,b 5c compound 9a showed more potent antiproteinase aspirin in...

Background: Diethylnitrosamine (DENA), a well-known dietary carcinogen, related to cancer initiation of variousorgans. The present study investigated the deleterious mechanisms involved in early destructive changes DENAin different organs namely, liver, stomach and colon potential protective effect GE against these mechanisms.Methods: Adult male albino rats were assigned into four groups. A normal control group received vehicle, anothergroup was injected with single necrogenic dose DENA (200...

Diabetes is the most common metabolic disorder in both developing and non-developing countries, a well-recognized global health problem. The WHO anticipates an increase cases from 171 million 2000 to 366 by 2030. In present study, we focus on preparation of pyrimidine derivatives as potential antidiabetic antimicrobial agents. Thein vivoeffect total serum glucose concentration, cholesterol antioxidant activity was assessed adult male albino Wister rats compared reference drug glimperide....

Abstract Purpose In several nations, it has been known that Boswellia carterii (BC) plants have a long history of usage as an anti-inflammatory medicine. Our current study deals with the two different ways extraction BC volatile oil and fixed main constituents (Octyl acetate, 46.46% β-Boswellic acid, 10.21%, respectively), preparation, evaluation Nano sponges loaded either dexamethasone (DEX) or B. volatile/fixed mixture. Methods were created utilizing ultrasound-assisted synthesis method....

Background/aim Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Increased oxidative stress has been shown to be prominent and early feature in AD. Medicinal plants with antioxidant activities have used traditionally the treatment of several human diseases. The present study aimed investigate possible prophylactic therapeutic effects aqueous infusions Boswellia serrata on AD induced rats. Materials methods Ninety adult male Sprague Dawley rats were enrolled this...

Boswellia carterii (BC) resins plants have a long historical background as treatment for inflammation, indicated by information originating from multiple countries. Twenty-seven diterpenoids been identified in ethyl acetate and total methanol BC, comprising seventeen boscartins of the cembrane-type ten boscartols prenylaromadendrane-type diterpenoids. Moreover, twenty-one known triterpenoids also found, encompassing nine tirucallane-type, six ursane-type, four oleanane-type, two lupane-type....

Honey is a natural sweet substance that bees produce by transforming flower nectar or other secretions of plants. It has widespread use in traditional medicine various parts the world. been reported to assist building entire central nervous system. The beneficial effects honey have attributed possible polyphenolic contents and some constituents. geographical locations sources plant nectars may contribute samples. Thus, we evaluated neuropharmacological six samples (10%, 20% 40%V/v, p.o.)...

Fruit by-products are considered nature's golden gift for human health and a good starting point to discover new drugs depending on the fact that they contain millions of bio-active compounds responsible therapeutic activities. In this context, main goal study is recycle Citrus aurantium (C. aurantium) seeds produce pharmaceutical molecules be used in prevention progressive neurological damage associated with Alzheimer disease (AD). Donepezil (0.75 mg/kg), hesperidin (125 250 mg/kg)...

Brain damage caused by cerebral ischaemia/reperfusion (I/R) can lead to handicapping. So, the present study aims evaluate prophylactic and therapeutic effects of geraniol in form intranasal polymeric mixed micelle (PMM) on central nervous system injury. A 32 factorial design was used prepare optimize PMM investigate polymer stabilizer different concentrations particle size (PS) percent entrapment efficiency (%EE). F3 possessing highest desirability value (0.96), with a PS 32.46 ± 0.64 nm, EE...

Abstract Musa acuminata (MA) is a popular fruit peels in the world. Non-food parts of plant have been investigated for their antioxidant and anti-ulcerative colitis activity. Metabolomic approaches were found to be informative as screening tool. It discovered different metabolites depending on statistical analysis. The activity content was measured by colorimetric method. Seventy six observed. identities some these markers confirmed based MS 2 fragmentation NMR spectroscopy. These include:...

The relationship between the incidence of cardiovascular abnormalities and non-alcoholic fatty liver disease (NAFLD) has long been postulated. Curcumin (CUR) is a potential anti-atherosclerotic agent but its poor water solubility hinders pharmacological use. Therefore, present study aimed to investigate effect formulation CUR nanoemulsion prepared using spontaneous emulsification technique on high fat fructose (HFHF)-induced hepatic cardiac complications. Fifty Wistar rats were divided into...

<title>Abstract</title> <bold>Background:</bold> Drug-resistant epilepsy is characterized by the failure of adequate trials two well selected anti-seizure drugs with tolerable side effects. Surgical intervention often performed to mitigate or stop seizures. Different imaging techniques are used evaluate those patients presurgically. Herein, we aimed describe correlation between seizure semiology, long term video-EEG and neuro-imaging modalities including high resolution three-dimensional...

Abstract Alzheimer’s disease (AD) is a widespread condition that affects adults and the community considerably. The causes are yet unknown, except from advanced age genetic predisposition. Natural products provided advantageous advantages for managing AD due to their efficacy, safety, accessibility. memory boosting effects of chemically characterized Ipomoea carnea ethanol extract (IPC-EtOH) on behavioral, biochemical, histological, molecular levels against cognitive impairment induced by...

<title>Abstract</title> <bold>Background and Aim: </bold>Acute allergic contact dermatitis is an inflammatory skin condition characterized by swollen, itchy lesions. This study aimed to evaluate the soothing wound-healing effects of fixed volatile oils <italic>Boswellia sarca</italic>, as well extracts <italic>Glycyrrhiza glabra</italic> <italic>Acacia nilotica</italic>, on acute in rats. <bold>Materials Methods</bold>: Phytochemical analysis revealed presence flavonoids, tannins, saponins,...

The possible protective effect of Ginger on Alzheimer’s disease induced in rats was investigated. Ninety were used as follows: control group, AD group using AlCl3, 3rd, 4th, and 5th groups received orally Rivastigmine, (108 216 mg/kg/day) respectively, for two weeks followed by combination each treatment another 4 weeks. 6th is a therapeutic while 7th, 8th & 9th are treated with the same doses Rivastigmine 12 At baseline after treatment, behavioral stress tests, Rotarod T-Maze tests done....

Gastric ulcer and hepatotoxicity due to irrational drug overuse are two of the most serious conditions associated with inflammation oxidative stress that affect digestive system. This study aimed experimentally evaluate hepatoprotective/gastroprotective effects aqueous butanol citrus peel extracts hesperidin in rat models hepatotoxicity. Acute toxicity was performed for determining safe dose analyze efficacy. In experiments on hepatoprotective gastroprotective effects, rats were classified...

Pimenta racemosa tree has many traditional uses where its leaves are used as herbal tea for treatment of flatulence, gastric disorder, osteoarthritis, colds and fever in addition to analgesic anti-inflammatory activities. So, this study aimed isolate phenolic constituents 80% aqueous methanol extract (AME) evaluate biological The defatted AME was chromatographed structures the isolated compounds were elucidated using UV, NMR spectroscopy UPLC-ESI-MS analysis. Antioxidant activity...

Objective: Hypertension is a chronic medical condition. Diet can improve blood pressure control and decrease the risk of health complication.Methods: In this study, four plants: Roselle, Marjoram, Chamomile, Doum were extracted by water. Equal portions them mixed. Lethaldose 50% mixture was assayed; dose which did not cause any mortality 266.94 mg/100 g body weight. Animals classified into fivegroups: Negative group, positive group where hypertension induced L-name, two groups treated with...

Gastric and duodenal ulcers affect a considerable number of people in the world.Young women have lower prevalence ulcer than age-matched men.Female hormones modulatory role on vascular permeability increase mucus secretion.Administration progesterone to female rats decreases ulcerations.Flaxseed oil has anti-inflammatory properties.The aim this study was show protective effect flaxseed against ethanol induced gastric ulcer.Rats were classified into non ovariectomized negative control groups,...

Hyperlipidemia is characterized by abnormally elevated levels of lipids and positively associated with cerebrovascular diseases. The aim the present study was evaluation possible effects allopurinol against brain injury in hyperlipidemic rats. induced maintaining rats on high fat diet for 6 weeks. prepared adding 1% cholesterol powder, 0.2% cholic acid, 10% to rat powdered standard laboratory diet., At end 4th week animals were treated fluvastatin (2.5 mg/kg, p.o) three dose (50, 100 200...

Hypertension is one of the most typical causes morbidity and mortality. The present study investigated possible antihypertensive cardiovascular effects an herbal mixture extract Hibiscus, Corn silk, Marjoram, Chamomile. HPLC analysis water prepared from aerial parts four plants their was done to detect predominant compounds. A safety prior efficacy determine dose ensure extract's in female rats. induced ovariectomized non-ovariectomized rats by oral administration 50 mg/kg LName for 30 days;...