ABSTRACT Introduction Cystic echinococcosis (CE) is a serious global health concern. CE an endemic zoonotic disease in Iran. The substantial genetic diversity of Echinococcus granulosus closely linked to its life cycle, transmission mechanisms and pathogenesis. This study aimed explore the phylogenetic structure genotypes E. sensu lato (s.l.) southwestern Iran (SWI). Methods Seventy‐two hydatid cyst samples were collected from various intermediate hosts, including goats, cattle, sheep,...

Nanoparticles (NPs) with unique chemical and physical properties can be used for therapeutic purposes because of their strong antimicrobial activates. have been as an agents to inhibit microbial growth.In view the activity nanoparticles, biogenic synthesis leishmanicidal rod-shaped zinc oxide (R-ZnO) nanoparticles was explored using Lilium ledebourii tuber extract.The ensuing are characterized by UV-visible spectroscopy, X-ray diffraction transmission electron microscopy evaluated against...

Given the numerous adverse effects of lung cancer treatment, more research on non-toxic medications is urgently needed. Curcumin (CUR) and berberine (BBR) combat drug resistance by controlling expression multidrug resistant pump (MDR1). Fascinatingly, combining these increases effectiveness preventing cancer. Their low solubility poor stability, however, restrict their therapeutic efficacy. Because improved bioavailability increased encapsulation water-insoluble medicines, surfactant-based...

The Toxoplasma gondii calcium-dependent protein kinase-3 (CDPK3) is a key enzyme for parasite egress, control of permeabilization in parasitophorous vacuole membrane and tissue cyst formation. In this study, we comprehensively explored the bioinformatics features to improve vaccine design against T. gondii.Various web servers were employed analysis physico-chemical properties, post-translational modifications, localization subcellular milieu, secondary tertiary structures, as well B-cell,...

Background. This research was aimed at evaluating the seroprevalence of acute and chronic Toxoplasma gondii (T. gondii) infection in pregnant women related risk factors southwest Iran. Methods. In this cross-sectional study, eighty-eight were included from October 2019 to December 2019. The presence anti-T. IgM IgG antibodies measured using enzyme-linked immunosorbent assay (ELISA). addition, a questionnaire consisting demographic information completed for each subject. Results. overall T....

Background: Toxoplasmosis is a zoonotic parasitic disease that affects many different species, including humans. It can cause serious clinical symptoms, neurological symptoms and abortion. Toxoplasma gondii, the causative agent, particularly concerning due to sheep's extraordinary sensitivity disease. spread zoonotically through ingestion of undercooked meat from infected animals. Numerous global investigations have demonstrated T. gondii seroprevalence in sheep vary greatly based on...

The probable association between Toxoplasma gondii (T. gondii) infection and diabetes mellitus (DM) is still controversial, there are several studies with conflicting results. Thus, this study was performed to assess the possible chronic T. type 1 (T1DM) T2DM.In case-control study, a total of 105 diabetic subjects including 36 patients T1DM 69 T2DM were recruited. In addition, 150 nondiabetic enrolled as controls. Each case group had its own control group. participant completed structured...

The angiotensin-converting enzyme 2 (ACE2) and main protease (MPro), are the putative drug candidates for severe acute respiratory syndrome coronavirus (SARS-CoV-2). In this study, we performed 3D-QSAR pharmacophore modeling screened 1264479 ligands gathered from Pubchem Zinc databases. Following calculation of ADMET properties, molecular docking was carried out. Moreover, de novo ligand design performed. MD simulation then applied to survey behavior ligand-protein complexes. Furthermore,...

Toxoplasma gondii is a common protozoan parasite, which infects warm-blooded mammals, including mice and humans, throughout the world. The negative effects of T. infection on human reproductive system have been documented, especially in females. However, only few studies examined male system. Previous research shows that can induce DNA methylation some gene promoters, are key regulators spermatogenesis. Therefore, this study aimed to evaluate curcumin activity methyltransferases (DNMTs), as...

Abstract Objectives Toxoplasma gondii ( T. ), an obligate intracellular apicomplexan parasite, could affect numerous warm-blooded animals, such as humans. Calcium-dependent protein kinases (CDPKs) are essential Ca 2+ signaling mediators and participate in parasite host cell egress, outer membrane motility, invasion, division. Results Several bioinformatics online servers were employed to analyze predict the important properties of CDPK4 protein. The findings revealed that peptide has 1158...

Apicomplexan parasites, including Toxoplasma gondii (T. gondii), express different types of calcium-dependent protein kinases (CDPKs), which perform a variety functions, attacking and exiting the host cells. In current bioinformatics study, we have used several web servers to predict basic features specifications CDPK7 protein. The findings showed that has 2133 amino acid residues with an average molecular weight (MW) 219085.79 D. aliphatic index 68.78 grand hydropathicity (GRAVY) -0.331...

Background: Cutaneous leishmaniasis (CL) is a tropical parasitic infection that involves several factors in its pathogenesis, including oxidative stress. The stress CL may deplete antioxidant nutrients. Objectives: aim of the study was to measure glutathione peroxidase (GPx) activity patients with CL. Methods: investigation included 80 and healthy participants. A diagnostic kit used GPx activity. Results: results showed significant decrease patient group compared control (P < 0.001),...

Microplastic is one of the most important environmental challenges recent decades. Although abundance microplastics in water sources and bodies such as marine were investigated many studies, knowing requires more studies. In this study, litter was urban management primary microplastic secondary environment. For purpose, Clean Environment Index Cigarette Butt Pollution Index, used to interpret density estimate resources Khuzestan province, Iran. The results showed that studied cities...

The protozoan Toxoplasma gondii as an intracellular is widely prevalent in humans and animals. Infection generally occurs through consuming food contaminated with oocysts tissue cysts from undercooked meat. parasite carried sexual fluids like semen but there little information about the effect of T. on male reproductive system. In this study, we examined tachyzoites apoptosis induction type B spermatogonia (GC-1) cells. Fresh taken infected BALB/c mice, GC-1 spg cells were increasing...

Coronavirus disease 2019 (COVID-19) has become a global health challenge with high transmission and mortality rates. This study aimed to identify prognosis factors of the risk death among hospitalized patients COVID-19 in Behbahan City, southwest Iran. Methods: In this study, information 800 admitted Shahidzadeh Hospital City Iran from March 20, 2020, Jan 2021, was investigated. Thereafter, demographic information, clinical symptoms, vital signs, pharmacotherapy, Laboratory findings...

Background: Acute Toxoplasma gondii infection during pregnancy period can cause congenital toxoplasmosis. The aim of this study was to assess the seroprevalence rate immunoglobulin G (IgG) and M (IgM) antibodies against T. associated risk factors in southwest Iran. Methods: This performed on 88 pregnant women from October December 2019 Khorramshahr County, Khuzestan province, Anti-T. IgG IgM were tested through enzyme-linked immunosorbent assay (ELISA) method. Results: Following serological...