A5100730145- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Mesenchymal stem cell research
- Cancer Immunotherapy and Biomarkers
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Genomic variations and chromosomal abnormalities
- Dysphagia Assessment and Management
- Melanoma and MAPK Pathways
- Voice and Speech Disorders
- Immunodeficiency and Autoimmune Disorders
- Hearing, Cochlea, Tinnitus, Genetics
- AI in cancer detection
- Congenital Heart Disease Studies
- Quinazolinone synthesis and applications
- Amoebic Infections and Treatments
Ningbo No. 2 Hospital
2023-2025
University of British Columbia
2025
Fujian Medical University
2024-2025
Shanxi Medical University
2023-2024
Peking Union Medical College Hospital
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Second Hospital of Shanxi Medical University
2024
Moffitt Cancer Center
2023-2024
Huashan Hospital
2024
Fudan University
2024
Background The microbiota-gut-lung axis has elucidated a potential association between gut microbiota and idiopathic pulmonary fibrosis (IPF). However, there is paucity of population-level studies with providing robust evidence for establishing causality. This two-sample Mendelian randomization (MR) analysis aimed to investigate the causal relationship IPF as well lung function. Materials methods Adhering Mendel’s principle inheritance, this MR utilized summary-level data from respective...
Lymph node metastasis (LNM) plays a critical role in the prognosis of head and neck squamous cell carcinoma (HNSCC). To enhance prognostic predictions investigate molecular interplay between LNM HNSCC, we developed an LNM-associated gene signature. Data was sourced from The Cancer Genome Atlas (TCGA), encompassing RNA-sequencing clinical profiles. We stratified patients based on status identified differentially expressed genes (DEGs) lymph node-negative (N0) node-positive (N1-3) groups. A...
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Introduction Cervical cancer, a major global health concern, is primarily caused by human papillomavirus (HPV) infection. Although cervical intraepithelial neoplasia grade 2 (CIN2), precancerous lesion, exhibits high spontaneous regression rates (50%–60%), particularly in younger women, current clinical management lacks accurate risk stratification. This study examines HPV integration status as prognostic biomarker women aged 18–45 diagnosed with CIN2, the objective of developing predictive...
Leptomeningeal disease (LMD) remains a rapidly lethal complication for late-stage melanoma patients. Here, we characterize the tumor microenvironment of LMD and patient-matched extra-cranial metastases using spatial transcriptomics in small number clinical specimens (nine tissues from two patients) with extensive vitro vivo validation. The landscape is characterized by lack immune infiltration instead exhibits higher level stromal involvement. tumor-stroma interactions at leptomeninges...
Objective: This study aimed to evaluate the role of plasma cytokine detection in endometrial cancer screening and tumor progression assessment patients with abnormal uterine bleeding.Methods: In this multicenter retrospective cohort 287 bleeding, comprehensive clinical information laboratory assessments, including cytokines, routine blood tests, markers, were performed.Associations between indicators carcinogenesis/progression evaluated.The independent risk factors for deep myometrial...
Radiomics features hold significant value as quantitative imaging biomarkers for diagnosis, prognosis, and treatment response assessment. To generate radiomics ultimately develop signatures, various factors can be manipulated, including image discretization parameters (e.g., bin number or size), convolutional filters, segmentation perturbation, multi-modality fusion levels. Typically, only one set of is employed, resulting in a single "flavour" each feature. In contrast, we propose "tensor...
Leptomeningeal disease (LMD) remains a rapidly lethal complication for late-stage melanoma patients. The inaccessible nature of the site and lack understanding biology this unique metastatic are major barriers to developing efficacious therapies patients with LMD. Here, we characterize tumor microenvironment leptomeningeal tissues patient-matched extra-cranial sites using spatial transcriptomic analyses in vitro vivo validation. We show landscape LMD be characterized by immune infiltration...
The burgeoning recognition of the nexus between renal functionality and prevalence dementia has precipitated a surge in research endeavors. This study aims to substantiate causal relationship kidney dementia.
Abstract Leptomeningeal disease is a devastating complication characterized by the rapid onset of debilitating neurological symptoms and markedly poor prognosis. It diagnosed in 5-15% hematological cancers. Here, we aim to identify metabolic immune remodeling tumor leptomeningeal microenvironment Non-Hodgkin lymphoma through comprehensive multi-omic analysis patient specimens, vivo models, vitro functional studies. Cerebrospinal fluid (CSF) from (LML) patients tumor-free controls were...
Background: Benign ovarian tumors in children and adolescents require individualized decision-making, including considerations for fertility, physical psychological health. We aimed to compare outcome of single-port multiport laparoscopy with benign China.Methods: Data all patients diagnosed International Classification Diseases-10 codes the electronic medical records database six gynecological oncology centers Fujian Province, China were retrospectively reviewed. Children aged ≤18 years...
Chronic lymphocytic leukemia (CLL) is a subtype of mature B-cell proliferative neoplasms characterized by abnormally increasing lymphocytes in circulation. The diagnosis CLL usually established on peripheral blood analysis and typical flow cytometric immunophenotype rather than biopsy. In particular, the high RMH (Royal Marsden Hospital Scoring System for CLL) score has highly sensitive weight diagnostic value. However, immunophenotyping cytometry may also be misleading specific clinical...
Abstract Purpose The immune cells that infiltrate the tumor microenvironment most frequently are tumor-associated macrophages (TAMs). Increasing evidence has shown positive correlation of TAMs with poor outcomes in human cancers. Yet, only a small number studies have revealed unique TAM characteristic HNSCC. development TAM-related forecasting model HNSCC was main aim this research. Methods Tumor Immune Single-cell Hub single-cell RNA-seq database searched to investigate putative genes Using...
Leptomeningeal disease (LMD) remains a rapidly lethal complication for late-stage melanoma patients. The inaccessible nature of the site and lack understanding biology this unique metastatic are major barriers to developing efficacious therapies patients with LMD. Here, we characterize tumor microenvironment leptomeningeal tissues patient-matched extra-cranial sites using spatial transcriptomic analyses
Abstract Background : Acute myeloid leukemia (AML) is a complex hematological disease characterized by genetic and clinical heterogeneity. The identification understanding of chromosomal abnormalities are important for the diagnosis management AML patients. Compared with recurrent translocations in AML, t(8;16)(p11.2;p13.3) can be found any age group but very rare typically associated poor prognosis. Methods Conventional cytogenetic studies were performed among 1,824 patients recorded our...
Abstract Background : Acute myeloid leukemia (AML) is a complex hematological disease characterized by genetic and clinical heterogeneity. The identification understanding of chromosomal abnormalities are important for the diagnosis management AML patients. Compared to recurrent translocations in AML, t(8;16)(p11.2;p13.3) can be found any age group, but very rare typically associated with poor prognosis. Methods Conventional cytogenetic studies were performed among 1,824 patients from our...
Abstract Mesenchymal stem cells (MSC) are a popular candidate in cellular therapy for many diseases. MSCs well known by their feature of self-renewal and differentiation potential. NESTIN is cytoskeletal protein expressed MSC that functions directly cell proliferation differentiation. Here, we demonstrated adding UltraGRO, medium supplement, could maintain partially recover the expression human umbilical cord derived (UC-MSCs). Furthermore, UC-MSCs cultured with UltraGRO showed better...
Abstract Mesenchymal stem cells (MSC) are a popular candidate in cellular therapy for many diseases. It is well known by its feature of self-renewal and differentiation potential. NESTIN cytoskeletal protein that expresses MSC plays an important role cell proliferation differentiation. Here, we demonstrated adding UltraGRO, which medium supplement, could maintain partially recover the expression human umbilical cord derived MSCs (UC-MSCs). Furthermore, UC-MSCs cultured with UltraGRO showed...