A5103158070- CRISPR and Genetic Engineering
- Transgenic Plants and Applications
- SARS-CoV-2 and COVID-19 Research
- Plant tissue culture and regeneration
- Genetically Modified Organisms Research
- COVID-19 Clinical Research Studies
- Animal Genetics and Reproduction
- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- SARS-CoV-2 detection and testing
- Vector-borne infectious diseases
- Viral Infections and Vectors
- Insect and Pesticide Research
- Bioeconomy and Sustainability Development
- Biochemical and Molecular Research
- Autophagy in Disease and Therapy
- Plant Micronutrient Interactions and Effects
- RNA regulation and disease
- Mosquito-borne diseases and control
- Cancer Immunotherapy and Biomarkers
- Toxin Mechanisms and Immunotoxins
- Fungal Infections and Studies
- Neuroscience and Neuropharmacology Research
- Immunotherapy and Immune Responses
- Herpesvirus Infections and Treatments
Euroimmun Medizinische Labordiagnostika (Germany)
2022
University of Montana
2017
University of California, San Diego
2017
Universitat de Lleida
2008-2014
Human cytomegalovirus (HCMV) is the top viral cause of birth defects worldwide, and current therapies have high toxicity. We previously reported that mTOR-independent autophagy-inducing disaccharide trehalose inhibits HCMV replication in multiple cell types. Here, we examine mechanism inhibition introduce autophagy inducer SMER28 as an additional inhibitor acting through a different mechanism. find induces vacuolation acidification vacuoles debris, including debris with appearance consistent...
Introduction: Lyme disease (LD) affects ∼476,000 people each year in the United States. Symptoms are variable and include rash flu-like symptoms. Reasons for wide variation outcomes unknown. Powassan virus (POWV) is a tick-borne flavivirus that causes ranging from asymptomatic infection to encephalitis, neurologic damage, death. POWV LD geographic case distributions overlap, with Ixodes species ticks as common vectors. Clinical ramifications of coinfection or sequential
Cereal seeds are versatile platforms for the production of recombinant proteins because they provide a stable environment protein accumulation. Endogenous seed storage proteins, however, include several prolamin-type polypeptides that aggregate and crosslink via intermolecular disulfide bridges, which could potentially interact with multimeric such as antibodies, assemble in same manner. We investigated this possibility by sequentially extracting human antibody expressed maize endosperm,...
Abstract Background In 2023, the US Food and Drug Administration approved LEQEMBI, a monoclonal antibody therapy targeting beta-amyloid plaques, for patients with early-stage Alzheimer’s disease (AD). However, anti-amyloid drug trials demonstrated an elevated risk amyloid-related imaging abnormalities cerebral edema (ARIA-E) in carriers of AD allele apolipoprotein E epsilon 4 (APOE-ɛ4), especially ɛ4/ɛ4 homozygous individuals [1-3]. Here, we report on evaluation new real-time polymerase...
Abstract Background Serodiagnosis of Lyme disease caused by Borrelia burgdorferi commonly affords the combination a sensitive antibody screening test followed confirmatory immunoblot analysis. We developed and evaluated new system enabling multiparametric analysis anti-Borrelia antibodies means miniaturized line blots in fully automated microplate format. Methods The EUROMicroblots Anti-Borrelia (IgG IgM, EUROIMMUN) are based on diagnostically relevant Borrelia-specific antigens. Diagnostic...
<h3>Objective</h3> To assess adaptive immunity to SARS-CoV-2 in anti-CD20 treated individuals with mRNA vaccination. <h3>Background</h3> Anti-CD20 therapies attenuate humoral responses vaccines. However, their effect on T cell is less clear. We examined B and following COVID-19 vaccination patients receiving therapy for multiple sclerosis (MS) other autoimmune inflammatory neurologic diseases (AINDs, e.g., encephalitis, stiff person syndrome, etc.). <h3>Design/Methods</h3> MS AIND were...
Abstract Background T-cell responses are a crucial constituent in the adaptive immunity to SARS-CoV-2 and can be quantified using interferon-gamma (IFN-γ) release assays (IGRAs). This study aimed at comparing results of two commercial IGRA systems, EUROIMMUN Quan-T-Cell Oxford Immunotec T-SPOT.COVID, presenting first head-to-head comparison these for evaluation SARS-CoV-2-specific activity. Methods Blood samples were collected Public Health Institute Ostrava from 90 health care professionals...
Abstract Background Autoantibodies against the glomerular basement membrane (GBM) are important markers in diagnosis and monitoring of autoimmune glomerulonephritides. Fast reliable detection these autoantibodies is crucial as anti-GBM disease can progress rapidly with fatal outcome. Here, we investigated diagnostic performance a newly developed, standardized chemiluminescence immunoassay (ChLIA). Methods The EUROIMMUN Anti-GBM ChLIA (IgG), processed on RA Analyzer 10, was assessed using...