A5012926945- Gene Regulatory Network Analysis
- Respiratory viral infections research
- Influenza Virus Research Studies
- Bacterial Genetics and Biotechnology
- RNA and protein synthesis mechanisms
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Pneumonia and Respiratory Infections
- Single-cell and spatial transcriptomics
- Pharmacovigilance and Adverse Drug Reactions
- Viral Infections and Vectors
- Neonatal Respiratory Health Research
- Smoking Behavior and Cessation
- COVID-19 Impact on Reproduction
- Viral gastroenteritis research and epidemiology
- Bioinformatics and Genomic Networks
- Long-Term Effects of COVID-19
- Microfluidic and Bio-sensing Technologies
- Microbial Metabolic Engineering and Bioproduction
- Vaccine Coverage and Hesitancy
- Statistical Methods in Clinical Trials
- Protein Degradation and Inhibitors
- Evolution and Genetic Dynamics
- Social and Educational Sciences
- Biosimilars and Bioanalytical Methods
Instituto de Salud Carlos III
2023-2025
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
2023-2025
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2024
Centro de Investigación Biomédica en Red
2024
South Dakota State University
2022
Institute for Integrative Systems Biology
2022
SIB Swiss Institute of Bioinformatics
2019-2021
University of Basel
2014-2021
Although it is well appreciated that gene expression inherently noisy and transcriptional noise encoded in a promoter’s sequence, little known about the extent to which levels of individual promoters vary across growth conditions. Using flow cytometry, we here quantify Escherichia coli genome-wide 8 conditions find systematically decrease with rate, condition-dependent lower bound on noise. Whereas constitutive consistently exhibit low all conditions, regulated are both more average variable...
The impact of RSV in older adults is under-recognized, and the limited existing studies on incidence hospitalizations show great variability. This study aims to estimate seasonal rates (IRs) among aged 60 (≥60) evaluate how different case definitions influence these estimates. A prospective, multicentre observational with active monitoring conducted over 10 seasons (2010/2011 2019/2020) 4-10 hospitals (depending season) that covered 21-46% region's total population (around 5 million people)....
We aimed to identify influential drivers of the cost-effectiveness older adult respiratory syncytial virus (RSV) vaccination in Denmark, Finland, Netherlands and Valencia-Spain. A static multi-cohort model was parameterised using country- age-specific hospitalisations three approaches: (A) International Classification Diseases (ICD)-coded hospitalisations, (B) laboratory RSV-confirmed (C) time-series modelling (TSM). Plausible hypothetical RSV vaccine characteristics were derived from two...
Abstract Background With the licensure of maternal respiratory syncytial virus (RSV) vaccines in Europe and United States, data are needed to better characterize burden RSV-associated acute infections (ARI) pregnancy. The current study aimed determine among pregnant individuals proportion ARI testing positive for RSV incidence rate, hospitalizations, deaths, perinatal outcomes. Methods We conducted a systematic review, following PRISMA 2020 guidelines, using 5 databases (Medline, Embase,...
This study explores the relationship between influenza infection, both clinically diagnosed in primary care and laboratory confirmed hospital, atherothrombotic events (acute myocardial infarction ischemic stroke) Spain. A population-based self-controlled case series design was used with individual-level data from electronic registries (n = 2 230 015). The risk of subjects ≥50 years old increased more than 2-fold during 14 days after mildest cases patients fewer factors 4-fold severe most...
The reconstruction of genome-scale metabolic models and their applications represent a great advantage systems biology. Through use as flux simulation models, production industrially-interesting metabolites can be predicted. Due to the growing number studies driven by increasing genomic sequencing projects, it is important conceptualize steps analysis. We have focused our work in cyanobacterium Synechococcus elongatus PCC7942, for which several analyses insights are unveiled. A comprehensive...
Fluorescence flow cytometry is increasingly being used to quantify single-cell expression distributions in bacteria high-throughput. However, there has been no systematic investigation into the best practices for quantitative analysis of such data, what biases exist, and accuracy sensitivity can be obtained. We investigate these issues by measuring same E. coli strains carrying fluorescent reporters using both microscopic setups systematically comparing resulting distributions. Using...
The aim of this study was to assess the possible extent bias due violation a core assumption (event-dependent exposures) when using self-controlled designs analyse association between COVID-19 vaccines and myocarditis.
Introduction: Respiratory Syncytial Virus (RSV) is a major cause of morbidity in older adults. With the emergence coronavirus disease 2019 (COVID-19) and subsequent changes respiratory viral circulation, it crucial to reassess RSV-associated healthcare burden This study assessed adults six European countries before during COVID-19 pandemic. Methods: We conducted retrospective analysis using national hospital admissions data from Denmark, England, Finland, Netherlands, Scotland, regional...
Abstract We test the robustness of self-controlled risk interval (SCRI) design in a setting where time between doses may introduce time-varying confounding, using both negative control outcomes (NCOs) and quantitative bias analysis (QBA). All vaccinated cases identified from 5 European databases September 1, 2020, end data availability were included. Exposures 1-3 Pfizer, Moderna, AstraZeneca, Janssen COVID-19 vaccines; myocarditis and, as NCO, otitis externa. The SCRI used 60-day window...
Abstract Background We aimed to identify influential drivers of the cost-effectiveness older adult respiratory syncytial virus (RSV) vaccination in Denmark, Finland, Netherlands and Valencia-Spain. Methods A static multi-cohort model was parameterised using country-and age-specific hospitalisations three approaches: (1) International Classification Diseases (ICD)-coded hospitalisations, (2) laboratory RSV-confirmed (3) time-series modelling (TSM). Plausible hypothetical RSV vaccine...
Abstract Although it is well appreciated that gene expression inherently noisy and transcriptional noise encoded in a promoter’s sequence, little known about the variation across growth conditions. Using flow cytometry we here quantify E. coli genome-wide 8 conditions, find regulation are intimately coupled. Apart from growth-rate dependent lower bound on noise, individual promoters show highly condition-dependent shaped by propagation regulators to their targets. A simple model of...
Abstract Fluorescence flow cytometry is a highly attractive technology for quantifying single-cell expression distributions in bacteria high-throughput. However, so far there has been no systematic investigation of the best practices quantitative analysis such data, what biases exist, and accuracy sensitivity can be obtained. We here investigate these issues by systematically comparing measurements fluorescent reporters E. coli with same strains microscopic setups develop method rigorous...
Abstract Introduction The aim of this study was to assess the possible extent bias due violation a core assumption (event-dependent exposures) when using self-controlled designs analyse association between COVID-19 vaccines and myocarditis. Methods We used data from five European databases (Spain: BIFAP, FISABIO VID, SIDIAP; Italy: ARS-Tuscany; England: CPRD Aurum) converted ConcePTION Common Data Model. Individuals who experienced both myocarditis were vaccinated against 1 September 2020...