A5090130293- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease and Transplantation
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal and GI Pathology
- Gastrointestinal disorders and treatments
- Gallbladder and Bile Duct Disorders
- Organ Transplantation Techniques and Outcomes
- Gastrointestinal Bleeding Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Esophageal Cancer Research and Treatment
- Nutrition and Health in Aging
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Liver Diseases and Immunity
- Folate and B Vitamins Research
- Colorectal Cancer Screening and Detection
- Biliary and Gastrointestinal Fistulas
- Mosquito-borne diseases and control
- Abdominal Trauma and Injuries
- Cancer Risks and Factors
- Genetic factors in colorectal cancer
Gangneung Asan Hospital
2017-2023
Inje University Sanggye Paik Hospital
2021-2023
University of Ulsan
2017-2021
Ulsan College
2017-2021
Inje University
2021
Soonchunhyang University
2011-2016
Background/Aims Therapies involving bone-marrow-derived mesenchymal stem cells (BM-MSCs) have considerable potential in the management of hepatic disease. BM-MSCs been investigated regenerative medicine due to their ability secrete various growth factors and cytokines that regress fibrosis enhance hepatocyte functionality. The aim this study was determine antifibrosis effect on activated stellate (HSCs) mechanism underlying how modulate function HSCs. Methods We used HSCs both direct...
Background/aims Recent studies have demonstrated the utility of FibroScan® device in diagnosing liver steatosis, but its usefulness has not been thoroughly appraised. We investigated controlled attenuation parameter (CAP) detecting and quantifying steatosis. Methods A prospective analysis was applied to 79 chronic disease patients who underwent a biopsy, FibroScan investigation, ultrasonography, hepatic steatosis index (HSI). The presence degree as measured by device, ultrasonography HSI...
Patients with liver cirrhosis and hepatocellular carcinoma (HCC) are often ineligible for resection or local ablation therapy due to poor function and/or difficult location. The aim of this study is evaluate therapeutic outcomes stereotactic body radiotherapy (SBRT) combined transarterial chemoembolization (TACE) compared TACE alone HCC measuring less than 5 cm. From March 2011 December 2016, 85 patients underwent SBRT (SBRT-TACE group) 114 (TACE at 4 tertiary hospitals. Local control rate...
Background and aims We investigated associations between body mass index (BMI) hepatocellular carcinoma (HCC) in patients with hepatitis B (HBV) C (HCV) virus infection, alcoholic liver disease (ALD), non-alcoholic fatty (NAFLD), cirrhosis (LC). Methods followed 350,608 Korean who underwent routine health examinations from 2003–2006 until December 2018 via national hospital discharge records. Multivariable adjusted hazard ratios (HRs) per 5-kg/m 2 BMI increase (BMI ≥25 kg/m ) for HCC risk...
The aim of this study was to investigate parameters that predict radiation-induced liver disease (RILD) following stereotactic body radiotherapy (SBRT) in patients with hepatocellular carcinoma (HCC) and identify the clinical significance RILD.We retrospectively reviewed medical records 117 HCC who were treated by SBRT from March 2011 February 2015. RILD defined as elevated transaminases more than five times upper normal limit or a worsening Child-Pugh (CP) score 2 within 3 months after...
Convincing data that support routine use of preventive therapy against hepatitis B virus (HBV) reactivation in radiotherapy (RT) for hepatocellular carcinoma (HCC) are lacking. The aim this study was to investigate the incidence, clinical significance, and risk factors HBV after RT. Medical records 133 HBsAg (+) HCC patients who received from March 2009 February 2016 were reviewed. Patients divided into two groups: 1) non-antiviral group, those did not receive antiviral before RT (n = 27);...
Ingested foreign objects frequently require emergency removal. This study aimed to investigate the clinical outcomes of endoscopic removal bodies from upper gastrointestinal tract and risk factors for adverse events.Adults (> 18 years) who underwent management ingested at two centers, one inland on coast, between January 2008 December 2017 were eligible. Clinical characteristics procedure-related retrospectively reviewed. Patients divided into groups, based whether sharp or blunt in shape.A...
Background/Aims: Plug-assisted retrograde transvenous obliteration (PARTO) is widely used to manage gastric varices with a portosystemic shunt.It not clear whether portal pressure and the incidence of complications increase after PARTO.The aim this study was determine changes in associated liver function, ascites, hepatic encephalopathy, especially esophageal varix (EV) PARTO.Methods: From March 2012 February 2018, 54 patients who underwent PARTO were analyzed retrospectively.The parameters...
OBJECTIVES: The optimal duration of fasting after endoscopic hemostasis in patients with peptic ulcer bleeding has not yet been determined. We investigated the appropriate timing feeding high-risk bleeding. METHODS: This study was a randomized, single center, noninferiority trial. Between February 2014 and March 2019, consecutive were randomized to resume either 24 or 48 hours successful hemostasis. A total 209 eligible included intention-to-treat analysis 200 per-protocol (PP) analysis....
Spontaneous bacterial peritonitis (SBP) is one of the severe complications liver cirrhosis. Early detection high-risk patients essential for prognostic improvement. The aim this study to investigate predictive factors related in-hospital mortality in with SBP. This was a retrospective 233 SBP (181 males, 52 females) who were admitted four tertiary referral hospitals between August 2002 and February 2013. patients' laboratory radiologic data obtained from medical records. Child-Turcotte-Pugh...
Background A complete virological response is closely related to the long-term outcome of patients with chronic hepatitis B and prevention emerging HBV mutations. We aimed evaluate efficacy tenofovir disoproxil fumarate (TDF) monotherapy compared entecavir-adefovir dipivoxil (ETV-ADV) combination therapy in suboptimal responses lamivudine-adefovir (LAM-ADV) for nucleoside analogue-resistant B. Methods Patients ( n=60) were randomized TDF or ETV-ADV 96 weeks. All had rt204I/V mutation serum...
Background and Aim: Previous studies reported that serum myostatin is associated with sarcopenia. We aimed to elucidate the association between levels hepatocellular carcinoma (HCC) development in patients alcoholic liver cirrhosis (ALC). Methods: This retrospective, multicenter study assessed 1077 Asian ALC enrolled from 2007 2017. The primary endpoint was of HCC within 5 years. Cox proportional hazards model analyses were used assess development. time-dependent areas under receiver...
Background/Aims: Sepsis-3 criteria and quick Sequential Organ Failure Assessment (qSOFA) have been advocated to be used in defining sepsis the general population. We aimed compare Chronic Liver Failure-SOFA (CLIF-SOFA) scores as predictors of in-hospital mortality cirrhotic patients admitted emergency department (ED) for infections.Methods: A total 1,622 cirrhosis at ED infections were assessed retrospectively. analyzed their demographic, laboratory, microbiological data upon diagnosis...
The optimal timing for discontinuing oral antiviral therapy in patients with HBeAg-positive chronic hepatitis B (CHB) is unclear. aim of our study was to investigate sustained remission after stopping CHB.We analyzed the medical records 58 who were and had discontinued therapy. Antiviral HBeAg seroconversion HBV DNA negativity 6-12 months consolidation Virologic relapse defined as an increase serum >2,000 IU/mL.No difference observed between virologic non-relapse groups baseline level...
Background/Aims Tenofovir disoproxil fumarate (TDF) plays a pivotal role in the management of drug-resistant chronic hepatitis B. However, it remains unclear whether TDF-nucleoside analogue combination therapy provides better outcomes than TDF monotherapy. This study aimed to compare efficacy monotherapy with that patients Methods retrospective cohort included 76 receiving TDF-based rescue for more 12 months. Suboptimal response was defined as serum HBV-DNA level >60 IU/mL during prior...
Background Hepatocellular carcinoma (HCC) recurrence after liver resection depends upon the stage and histological grade of tumor expression certain biomarkers. However, it remains unclear which these factors has highest predictive value regarding HCC surgical resection. Methods This study investigated associations among clinicopathological characteristics, biomarkers, Fifty-four patients having undergone for were enrolled prospectively, their data analyzed retrospectively. Evaluated...
Background/Aim Stereotactic body radiotherapy (SBRT) may be an alternative treatment for patients with small (≤3 cm) hepatocellular carcinomas (HCCs) who were not indicated resection or local ablation therapy. This study compared the therapeutic effects of radiofrequency (RFA) and SBRT in HCCs. Methods Data HCC underwent RFA as initial at four tertiary referral hospitals between March 2011 February 2017 reviewed. The patient inclusion criteria a single nodule measuring ≤3 cm size suitable...
Abstract Background Risk stratification before endoscopy is crucial for proper management of patients suspected as having upper gastrointestinal bleeding (UGIB). There no consensus regarding the role nasogastric lavage risk stratification. In this study, we investigated usefulness to identify with UGIB requiring endoscopic examination. Methods From January 2017 December 2018, who visited emergency department a clinical suspicion and underwent were eligible. Patients esophagogastric variceal...
Hyun Phil Shin, Jae Myung Cha, Beom Kyung Kim, Dae-Seong Myung, Sung-Hoon Moon, Myeong Jun Song, Seung Bae Yoon, In Yoo, Jeong Hoon Lee, Baek Gyu Jun, Jong Jin and On behalf of Education Committee the Korean Society Gastroenterology. J Gastroenterol 2021;77:205-13. https://doi.org/10.4166/kjg.2021.049