A5061984265- Autoimmune Bullous Skin Diseases
- Autoimmune and Inflammatory Disorders
- Urticaria and Related Conditions
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Drug-Induced Adverse Reactions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Digital Imaging in Medicine
- Vasculitis and related conditions
- Social Media in Health Education
- Acne and Rosacea Treatments and Effects
- Hidradenitis Suppurativa and Treatments
- Cutaneous lymphoproliferative disorders research
- Cutaneous Melanoma Detection and Management
- Urological Disorders and Treatments
- T-cell and B-cell Immunology
- Heparin-Induced Thrombocytopenia and Thrombosis
- Venous Thromboembolism Diagnosis and Management
- Hair Growth and Disorders
- Empathy and Medical Education
- Misinformation and Its Impacts
- Health Literacy and Information Accessibility
- Urologic and reproductive health conditions
- Medicine and Dermatology Studies History
- Eosinophilic Disorders and Syndromes
University of California, Davis
2022-2024
Oxford University Hospitals NHS Trust
2020-2023
San Francisco General Hospital
2023
University of California, San Francisco
2023
University of Oxford
2017-2022
National Health Service
2022
Churchill Hospital
2020-2021
Guy's and St Thomas' NHS Foundation Trust
2021
King's College London
2021
The Royal Free Hospital
2020
Proprotein convertase subtilisin/kexin type-9 (PCSK9) is a posttranslational regulator of the LDL receptor (LDLR). Recent studies have proposed role for PCSK9 in regulating immune responses. Using RNA-Seq–based variant discovery, we identified possible psoriasis-susceptibility locus at 1p32.3, located within (rs662145 C > T). This finding was verified independently acquired genomic and RNA-Seq data sets. Single-cell (scRNA-Seq) keratinocytes as primary source human skin. expression, however,...
ERAP1, ERAP2 and LNPEP are aminopeptidases implicated in autoimmune pathophysiology. Here, we demonstrate that is upregulated ERAP1 downregulated patients with psoriasis who homozygous for autoimmune-linked variants of ERAP. We also aminopeptidase expression not uniform the skin. Specifically, intracellular antigen-processing were strongly expressed basal early spinous layer keratinocytes, while granular keratinocytes predominantly LNPEP, an specialized processing extracellular antigens MHC...
This comparative effectiveness research study assesses the discriminatory ability of diagnostic criteria for pyoderma gangrenosum.
Aberrant glycan modifications have been hypothesized to drive autoimmune pathogenesis, especially those at the conserved immunoglobulin constant heavy chain domain 2 (CH2)-84.4 site of IgG ( Maverakis et al., 2015 E. Kim K. Shimoda M. Gershwin M.E. Patel F. Wilken R. al. Glycans in immune system and The Altered Glycan Theory Autoimmunity: a critical review. J Autoimmun. 2015; 57: 1-13 Crossref PubMed Scopus (343) Google Scholar ). this dictate Ig effector function, with agalactosylated...
Abstract Background Penile squamous cell carcinoma (PSCC) carries significant morbidity and mortality. Literature is limited regarding prognostic factors, especially factors for development of metastasis. Objectives To identify independent associated with poor outcomes, defined as local recurrence (LR), metastasis disease‐specific death (DSD) in clinically node‐negative PSCC undergoing therapy. Methods Thirty‐two‐year Retrospective Multicenter Cohort Study 265 patients histologically...
This research letter reports on a case series of 10 patients with bullous pemphigoid treated rituximab combined omalizumab.
Despite reaching historical lows in the early 2000s, cases of both primary and secondary syphilis congenital have increased dramatically U.S. over last decade. In U.S., current epidemic is disproportionately impacting communities that been historically underserved medicine. These include men who sex with men, especially those infected HIV; people color; reproductive-age women poor access to prenatal care. With now being more commonly diagnosed non-STI than STI clinics all genders, since...
Moezinia, Carine J. MBBS; Ji-Xu, Antonio BM, BCh; Singh, Animesh FRCP; Stratton, Richard FRCP, PhD Author Information
Patients with acne are increasingly using sunbeds as a self treatment despite the harmful effects. Little is known about sunbed use in adult patients under dermatology care. This questionnaire study explored prevalence and behaviours surrounding at UK centre. Over quarter (26%) of respondents used these, 72% them least weekly. Respondents were more likely to be older, female, have longer duration diagnosis previously been offered blue-light therapy by their doctor (P < 0.05 for all) Reasons...