A5060739115- Circular RNAs in diseases
- interferon and immune responses
- RNA modifications and cancer
- Wnt/β-catenin signaling in development and cancer
- MicroRNA in disease regulation
- Cardiovascular Health and Disease Prevention
- Cancer Mechanisms and Therapy
- Diagnosis and treatment of tuberculosis
- Natural Compounds in Disease Treatment
- HIV Research and Treatment
- Peroxisome Proliferator-Activated Receptors
- Ubiquitin and proteasome pathways
- Blood properties and coagulation
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- S100 Proteins and Annexins
- Blood Pressure and Hypertension Studies
- Inflammatory Bowel Disease
- Muscle activation and electromyography studies
- Cardiovascular Function and Risk Factors
- Metalloenzymes and iron-sulfur proteins
- Adenosine and Purinergic Signaling
- Extracellular vesicles in disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes and associated disorders
First Affiliated Hospital of Guangdong Pharmaceutical University
2017-2023
Sun Yat-sen University
2017-2018
Guangdong Pharmaceutical University
2018
The First Affiliated Hospital, Sun Yat-sen University
2018
Sixth Affiliated Hospital of Sun Yat-sen University
2017
In the nematode Caenorhabditis elegans, 22-nucleotide RNA sequence called spliced leader (SL) is trans-spliced from 100-nucleotide-long SL to some mRNAs. We have identified a (SL2) whose differs that of original (SL1), although both are 22 nucleotides long. By primer-extension sequencing, SL2 but not SL1 was shown be present at 5' end mRNA encoded by one four glyceraldehyde-3-phosphate dehydrogenase genes. The other three genes encode mRNAs their ends. Therefore, trans-splicing process can...
Abstract Background Few studies examined the relationship between triglyceride/glucose index (TyG index) and atherosclerosis in Japanese adults. Therefore, this study evaluated their relationship, as measured based on brachial-ankle pulse wave velocity (baPWV) Methods A total of 912 participants was selected from NAGALA (NAFLD Gifu Area, Longitudinal Analysis) conducted 2004 to 2012. The TyG baPWV estimated through a logistic model. Subgroup analyses by sex, age, body mass (BMI),...
Alzheimer's disease (AD) is the most common type of dementia and a serious social medical problem threatening human health. The present study investigated effect underlying action mechanism triptolide (Tri) on AD progression. Reverse transcription-quantitative PCR western blotting analysis were used to determine changes in RNA expression levels NF-κB signaling pathway proteins before after lipopolysaccharide (LPS) induction. Nucleocytoplasmic separation experiments determined intracellular...
β-Amyloid protein (Aβ) is thought to cause neuronal loss in Alzheimer's disease (AD). Aβ treatment promotes the re-activation of a mitotic cycle and induces rapid apoptotic death neurons. However, signaling pathways mediating cell-cycle activation during neuron apoptosis have not been determined. We find that Wnt5a acts as mediator cortical survival, Aβ42 by downregulating expression Wnt5a. Cell-cycle mediated reduced inhibitory effect treated Furthermore, signals through non-canonical...
Background: Glioma is the most lethal primary brain tumor, survival rate still isn't improved in past decades. It's essential to study regulatory mechanism of glioma progression, hoping find new therapy targets or methods. The family tripartite motif (TRIM) containing proteins are E3 ubiquitination ligases, which play critical role various tumor progression. Methods: Cell proliferation and invasion were analyzed by colony formation assay, soft agar growth BrdU incorporation assay transwell...
Ischemic stroke, which often occurs with high morbidity, disability, and mortality, is a main cause of brain disease. In various types human diseases, it found that microRNAs (miRNAs) are considered as gene regulators. Increasing studies have proved fluctuation miRNAs, in the pathologies ischemic plays vital role. However, accurate regulatory mechanism cerebral stroke by miRNAs still unclear. this research, we investigated inhibition miR-488-3p on neuronal death through targeting vacuolar...
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies gastrointestinal tract in world, and long-term prognosis for ESCC patients still remains dismal due to lack effective early diagnosis biomarkers.Western blot immunochemistry were used determine expression PRR11 201 clinicopathologically characterized specimens. The effects on stem cell-like traits tumorigenicity examined by tumor sphere formation assay SP assays vitro a tumorigenesis model vivo. mechanism which...
This research was aimed to explore correlation of gene polymorphisms CD36 and ApoE with susceptibility Alzheimer disease (AD). study a case–control study. Two hundred eleven AD hospitalized patients were selected as the group 241 subjects control group. PCR-RFLP used detect three loci (rs7755, rs3211956, rs10499859) genotype. Chi-square test univariate nonconditional logistic regression analysis calculate odds ratio (OR) 95% confidence interval (95% CI). The haplotypes constructed using...
Abstract Glioblastoma (GBM) is the main form of primary brain malignancies with a dismal prognosis partly due to its invasive growth and rapid relapse. GBM frequently developed resistance current standard‐of‐care therapeutic modalities, including surgery, radiation chemotherapy, which temozolomide (TMZ) most widely used first‐line anti‐GBM drug. Despite intense efforts past decades, underlying mechanisms TMZ remain largely unclear. Here we show that long noncoding RNA (lncRNA) PSMG3‐AS1...
This article explores the effects of myoelectric biofeedback therapy association with rehabilitation training on LLMF in patients stroke and hemiplegia. Sixty hemiplegia were separated into control group treatment group. The two groups disposed neuromedicine drugs training, while also increased affected side's lower limb electromyography. same therapist evaluated Fugl-Meyer score (FMA), M-B index (MBI), Berg Balance Scale (BBS), before 4 weeks after treatment, performed statistical analysis....
Objective To compare the safety and short-term efficacy between hand-assisted laparoscopic (HALS group) open right hemi-colectomy (open for Crohn′s disease (CD). Methods CD patients from 6th hospital of Sun Yat-sen university treated with HALS January 2013 2017 were included. Clinical differences two groups, such as clinical characteristics, operation time, blood loss, stoma rate, postoperative complications recovery analyzed. Results 8 underwent 39 surgery. No in preoperative...
Abstract Background: The triglyceride/glucose index (TyG index) has been suggested as a simple and reliable surrogate insulin resistance (IR) marker for years. However, the association between TyG arterial stiffness in adults is controversial. Therefore, we evaluated this relationship, measured based on brachial ankle pulse wave velocity (baPWV), Japanese adults. Methods: This study selected total of 912 participants from NAGALA (NAfld Gifu Area, Longitudinal Analysis) conducted 2004 to...