Both oxidative stress and inflammation are involved in the pathogenesis of contrast-induced nephropathy (CIN). Epigallocatechin-3-gallate (EGCG), a purified catechin from green tea, has antioxidant anti-inflammatory effects. However, it is unknown whether or not EGCG effective treating CIN. Our present study found that intravenous administration EGCG, either before just after establishment CIN, had protective effect, determined by normalization serum creatinine blood urea nitrogen levels,...

Abstract Contrast‐induced nephropathy (CIN) is a common complication with adverse outcome after iodinated‐contrast injection, yet still lacking effective medication. Heme oxygenase‐1 (HO‐1) has been reported to play an important role against renal injuries. Hemin, HO‐1 inducer and anti‐porphyria medicine, may have promising effect CIN. In this study, we aim investigate the of hemin on CIN model underlying molecular mechanisms in human proximal tubule epithelial cells (HK‐2). To mimic...

Abstract Background Few studies examined the relationship between triglyceride/glucose index (TyG index) and atherosclerosis in Japanese adults. Therefore, this study evaluated their relationship, as measured based on brachial-ankle pulse wave velocity (baPWV) Methods A total of 912 participants was selected from NAGALA (NAFLD Gifu Area, Longitudinal Analysis) conducted 2004 to 2012. The TyG baPWV estimated through a logistic model. Subgroup analyses by sex, age, body mass (BMI),...

Abstract Background Inflammation of RPE cells led to different kinds eye diseases and affected the normal function retina. Furthermore, higher levels ROCK1 ROCK2 induced injury endothelial many inflammatory eyes. Ripasudil, which was used for treatment glaucoma, one kind inhibitor ROCK2, but whether ripasudil could relieve LPS-induced inflammation damage not clear. Methods We LPS stimulate ARPE-19 cells, cell line. After that, we detected by western-blotting after stimulation ripasudil. Then...

Oxidative stress and inflammation are regarded as prime reasons for the progression development of diabetic retinopathy. Currently, nuclear factor erythroid-2-related 2 (Nrf2), thioredoxin interacting protein (TXNIP) NLRP3 inflammasome pathways under increasing focus in research on oxidative inflammation-related diseases. On other hand, tilianin (TN) has received much attention because its various pharmacological properties. Based results these studies, this investigation was performed to...

The phenotypic transformation of proliferation and migration in vascular smooth muscle cells (VSMCs) from media to intima is the basic pathology neointimal hyperplasia after angioplasty hypertensive patients. Angiotensin II (AngII) stimulates oxidative stress VSMC, inducing VSMC migration, which a critical factor both developments hypertension angioplasty‐induced arterial restenosis. Fisetin, plant flavonoid polyphenol, has been reported be antioxidative potent senolytic. It unknown whether...

Abstract Background To describe the clinical characteristics and analyze predictive factors associated with improved visual acuity of 359 patients infectious endophthalmitis. Methods This study retrospectively analyzed eyes endophthalmitis from January 2014 to December 2018. The findings summarized some epidemiological these patients, including age, sex, occupation, patient visit time, etiology, causative organisms, therapy, best-corrected acuity. Multivariate logistic regression was...

The present study aimed to investigate the mechanisms of anti‑VEGF treatment prior eye surgery reduce intraoperative bleeding. A total 30 patients with proliferative vitreoretinopathy after clinical diagnosis were enrolled in as surgical group. Furthermore, underwent intravitreal injection drug conbercept and considered pretreatment aqueous vitreous humors from eyes group drawn during pars plana vitrectomy surgery. humor was seven days immediately this only taken ELISA used detect levels...

To investigate the etiologies and clinical characteristics of full-thickness macular hole (FTMH) cases at Shanxi Eye Hospital in North China. Patients diagnosed with FTMH who underwent surgery from 2012 to 2020 were included, features MH types analyzed an 8-year, cross-sectional, retrospective study. A total 752 (776 eyes) analyzed. The top 3 subtypes idiopathic (IMH, 64.4%), myopic (MMH, 21.1%) traumatic (TMH, 3.7%) MH. Among these, there significant differences sex, age, baseline...

Objective. To investigate anatomical and visual outcomes of macular hole (MH) after inverted internal limiting membrane (ILM) flap technique for idiopathic (IMH). Methods. A total 13 IMH cases diagnosed in Shanxi Eye Hospital between January 2015 June 2016 were included the study. All patients underwent vitrectomy combined with indocyanine green-assisted ILM technique. The MH closure rate, best-corrected acuity (BCVA), changes ellipsoid zone (EZ), external (ELM) examined before operation...

Effect of roxarsone on the removal nutrients from wastewater.

Objective: To assess the correlations of type 2 diabetic retinopathy (DR) severity with vascular endothelial growth factor (VEGF), IL-6, IL-1 β and TNF- α oxidative stress. Methods: 80 patients DR were divided into non-proliferative (NPDR) group [NPDR + /diabetic macular edema (DME) − group], NPDR DME (NPDR /DME group), proliferative (PDR) (PDR group) PDR according to non-mydriatic fundus examination angiography. Another 20 without selected as control (DR group). VEGF, inflammatory factors...

Abstract Background: To describe the clinical characteristics and analyze predictive factors associated with improved visual acuity of 359 patients infectious endophthalmitis. Methods: This study retrospectively analyzed eyes endophthalmitis from January 2014 to December 2018. The findings summarized some epidemiological these patients, including age, sex, occupation, patient visit time, etiology, causative organisms, therapy best-corrected (BCVA). Multivariate logistic regression was...

Abstract Background: To investigate the etiologies and clinical characteristics of full-thickness macular hole (FTMH) cases at Shanxi Eye Hospital in North China. Methods : Patients diagnosed with FTMH who underwent surgery from 2012 to 2020 were included, features MH types analyzed an 8-year, cross-sectional, retrospective study. Results: A total 752 (776 eyes) analyzed. The top three causes idiopathic (IMH, 64.4%), myopic (MMH, 21.1%) traumatic (TMH, 3.7%) MH. Among these, there...

Soil profiles from 0 to 80 cm depth were collected and a 14-day incubation experiment at three soil moisture levels (initial moisture, water holding capacity, flooding) was carried out 25°C in the dark reveal effects of on nitrogen mineralization rates 10-yr floodplain wetland. Our results showed that decreased with along maximal appeared 10-20cm layer. The higher under flooding treatment compared another two treatments. Nitrogen top 20cm soils exhibited an increasing tendency moisture....

Soil profiles from 0 to 80 cm depth were collected at five typical zones (including permanently flooded floodplain (B), 1-year (O), 5-year (F), 10-year (T), and 100-year (H)) which are divided by different flooding frequencies along the direction penperdicular river channel in wetlands of Xianghai National Nature Reserve China. A 14-day incubation experiment was carried out 25°C dark reveal effects on nitrogen mineralization rates. Our results showed that rates an alternative tend...

Abstract Background: Inflammation of RPE cells led to different kinds eye diseases and affected the normal function retina. Furthermore, higher levels ROCK1 ROCK2 induced injury endothelial cell s many inflammatory eyes. Ripasudil, which was used for treatment glaucoma , one kind inhibitor ROCK2, but whether ripasudil could relieve LPS-induced inflammation damage not clear. Methods: We LPS stimulate ARPE-19 cells, line. After that, we detected by western-blotting after stimulation ripasudil....

Abstract Background: Inflammation of RPE cells led to different kinds eye diseases and affected the normal function retina. Furthermore, higher levels ROCK1 ROCK2 induced injury endothelial cell s many inflammatory eyes. Ripasudil, which was used for treatment glaucoma , one kind inhibitor ROCK2, but whether ripasudil could relieve LPS-induced inflammation damage not clear. Methods: We LPS stimulate ARPE-19 cells, line. After that, we detected by western-blotting after stimulation ripasudil....

Abstract Introduction Inflammation of RPE cells lead to different kinds eye diseases and affect the normal function retina. Furthermore, higher levels ROCK1 ROCK2 induced injury endothelial many inflammatory eyes. Ripasudil which was used for treatment glaucoma one kind inhibitor ROCK2. But whether ripasudil could relieved LPS inflammation damage not clear.Material methods We stimulate ARPE-19 is cell line. After that, we detected by western-blotting assay after stimulation ripasudil. Then...

Abstract Background: We aimed to clarify the epidemiological characteristics of thoracolumbar fractures (TLFs) at Shanxi Bethune Hospital, Academy Medical Sciences, China. Methods: A total 1,096 patients with TLF between January 2014 and December 2019 were included in this retrospective study. Epidemiological (year, age, sex, marital status, occupation, injury level, etiology, fracture type, American Spinal Injury Association ASIA impairment scale [AIS] grade) medical records extracted...

Abstract Background: The triglyceride/glucose index (TyG index) has been suggested as a simple and reliable surrogate insulin resistance (IR) marker for years. However, the association between TyG arterial stiffness in adults is controversial. Therefore, we evaluated this relationship, measured based on brachial ankle pulse wave velocity (baPWV), Japanese adults. Methods: This study selected total of 912 participants from NAGALA (NAfld Gifu Area, Longitudinal Analysis) conducted 2004 to...