The Himalayan mountains are dissected by some of the deepest and most impressive gorges on Earth. Constraining interplay between river incision rock uplift is important for understanding tectonic deformation in this region. We report here discovery a deeply incised canyon Yarlung Tsangpo River, at eastern end Himalaya, which now buried under more than 500 meters sediments. By reconstructing former valley bottom dating sediments base fill, we show that steepening Gorge started about 2 million...

MicroRNAs (miRNAs) are small noncoding RNAs that have a pivotal role in the post-transcriptional regulation of gene expression by sequence-specifically targeting multiple mRNAs. Although miR-33a was recently reported to play an important lipid homeostasis, atherosclerosis, and hepatic fibrosis, functions tumor progression metastasis largely unknown. Here, we found downregulated breast cancer tissues correlates with lymph node metastasis. MiR-33a is significantly lower highly metastatic cell...

Dietary factors can significantly affect the development of gastric and colorectal cancers; however, observational findings on impact micronutrients macronutrients risk cancers are inconsistent. It is crucial to clarify these relationships create nutritional recommendations for cancer prevention. A two-sample Mendelian randomization investigation was performed examine circulating levels 15 (such as vitamin A, folate, B6, B12, C, D, E, β-carotene, calcium, copper, iron, magnesium, phosphorus,...

Background: Numerous researches have demonstrated that miR-142-5p plays significant roles in several cancers, although the functional characteristic of breast cancer has not been determined. This study is designed to explore biological significance clinical implication and mechanism action. Methods: The differential expression patterns Sorbin SH3 domain-containing protein 1 correlations between them significances were analyzed based on data from database. levels cells detected using...

Oxidative stress and inflammation are regarded as prime reasons for the progression development of diabetic retinopathy. Currently, nuclear factor erythroid-2-related 2 (Nrf2), thioredoxin interacting protein (TXNIP) NLRP3 inflammasome pathways under increasing focus in research on oxidative inflammation-related diseases. On other hand, tilianin (TN) has received much attention because its various pharmacological properties. Based results these studies, this investigation was performed to...

Abstract Background Inflammation of RPE cells led to different kinds eye diseases and affected the normal function retina. Furthermore, higher levels ROCK1 ROCK2 induced injury endothelial many inflammatory eyes. Ripasudil, which was used for treatment glaucoma, one kind inhibitor ROCK2, but whether ripasudil could relieve LPS-induced inflammation damage not clear. Methods We LPS stimulate ARPE-19 cells, cell line. After that, we detected by western-blotting after stimulation ripasudil. Then...

MicroRNAs (miRNAs) are a group of small non-coding RNAs that directly bind to the 3'-untranslated-region (3'UTR) mRNA, thereby blocking gene expression post-transcriptionally. Accumulating evidence prove microRNA-873 (miR-873) functions as promoter or suppressor in various cancers, while whether it affects progression colorectal cancer (CRC) is yet unknown. Here we found miR-873 was downregulated human CRC clinical samples, mouse specimens and cell lines with high metastatic potential. We...

The abnormal expression of the chicken ovalbumin upstream promoter transcription factor 2 (COUP‑TFII) is associated with numerous forms cancer, including gastric, prostate, colon and lung cancer. However, previous studies investigating association between COUP‑TFII occurrence, recurrence, invasion metastasis gastric cancer are limited in number. In present study, it was revealed that significantly reduced carcinoma tissues compared normal mucosa cells (GES‑1). addition, also cell lines GES‑1...

// Haibin Wang 1, * , Guoxing Xu 2, Zhengjie Huang 3, Weizheng Li 4 Huali Cai 1 Yunda Zhang Disheng Xiong Gang Liu Shengjie Zengfu Xue and Qi Luo Department of Gastrointestinal Surgery, Xiamen Cancer Hospital, The First Affiliated Hospital University, 361003, Fujian, China 2 Endoscopy Center, 3 Clinical Medical College Fujian Fuzhou 350004, Prevention, Diagnosis Treatment, These authors have contributed equally to this work Correspondence to: Xue, email: zfxue@xmu.edu.cn Luo,...

Abstract Background To describe the clinical characteristics and analyze predictive factors associated with improved visual acuity of 359 patients infectious endophthalmitis. Methods This study retrospectively analyzed eyes endophthalmitis from January 2014 to December 2018. The findings summarized some epidemiological these patients, including age, sex, occupation, patient visit time, etiology, causative organisms, therapy, best-corrected acuity. Multivariate logistic regression was...

The present study aimed to investigate the mechanisms of anti‑VEGF treatment prior eye surgery reduce intraoperative bleeding. A total 30 patients with proliferative vitreoretinopathy after clinical diagnosis were enrolled in as surgical group. Furthermore, underwent intravitreal injection drug conbercept and considered pretreatment aqueous vitreous humors from eyes group drawn during pars plana vitrectomy surgery. humor was seven days immediately this only taken ELISA used detect levels...

To investigate the etiologies and clinical characteristics of full-thickness macular hole (FTMH) cases at Shanxi Eye Hospital in North China. Patients diagnosed with FTMH who underwent surgery from 2012 to 2020 were included, features MH types analyzed an 8-year, cross-sectional, retrospective study. A total 752 (776 eyes) analyzed. The top 3 subtypes idiopathic (IMH, 64.4%), myopic (MMH, 21.1%) traumatic (TMH, 3.7%) MH. Among these, there significant differences sex, age, baseline...

Breast cancer (BC) is one of the most aggressive malignancies worldwide among females. Matrix metalloproteinases (MMPs), as abundant class non-serine proteases present in invasive and metastatic tumors, can regulate a variety alterations microenvironment during tumor progression. However, differential expression MMPs its prognostic values BC yet to be elucidated. In this research, using ONCOMINE dataset, The Cancer Genome Atlas, Gene-Expression Miner v4.1 (Bc-GenExMiner), Kaplan-Meier...

Objective. To investigate anatomical and visual outcomes of macular hole (MH) after inverted internal limiting membrane (ILM) flap technique for idiopathic (IMH). Methods. A total 13 IMH cases diagnosed in Shanxi Eye Hospital between January 2015 June 2016 were included the study. All patients underwent vitrectomy combined with indocyanine green-assisted ILM technique. The MH closure rate, best-corrected acuity (BCVA), changes ellipsoid zone (EZ), external (ELM) examined before operation...

Objective: To assess the correlations of type 2 diabetic retinopathy (DR) severity with vascular endothelial growth factor (VEGF), IL-6, IL-1 β and TNF- α oxidative stress. Methods: 80 patients DR were divided into non-proliferative (NPDR) group [NPDR + /diabetic macular edema (DME) − group], NPDR DME (NPDR /DME group), proliferative (PDR) (PDR group) PDR according to non-mydriatic fundus examination angiography. Another 20 without selected as control (DR group). VEGF, inflammatory factors...