A5079977190- Ocular Surface and Contact Lens
- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Vibrio bacteria research studies
- Fermentation and Sensory Analysis
- Advanced biosensing and bioanalysis techniques
- Intraocular Surgery and Lenses
- Analytical Chemistry and Chromatography
- Immune Response and Inflammation
- Chemical Synthesis and Analysis
- Phytochemicals and Antioxidant Activities
- Ophthalmology and Visual Impairment Studies
- Aquaculture disease management and microbiota
- Meat and Animal Product Quality
- Antifungal resistance and susceptibility
- MXene and MAX Phase Materials
- Probiotics and Fermented Foods
- Insect and Pesticide Research
- Protein Hydrolysis and Bioactive Peptides
- Immunotherapy and Immune Responses
- Microbial Metabolites in Food Biotechnology
- Antimicrobial Peptides and Activities
- Proteins in Food Systems
- Food Quality and Safety Studies
- Advanced Memory and Neural Computing
Institute of Chemistry of the Slovak Academy of Sciences
2009-2025
Slovak Academy of Sciences
2014-2025
Food Research Institute
1988-1998
Southeastern University
1994
Institute of Experimental Endocrinology of the Slovak Academy of Sciences
1992
Institute of Chemical Engineering
1984
Comenius University Bratislava
1984
University of Regensburg
1980
This review presents the basic characteristics of MXene, a novel 2D nanomaterial with many outstanding properties applicable to electrochemical sensing and biosensing. The second part deals impedance spectroscopy (EIS) its beneficial features ultrasensitive label-free main recent advances in integration MXene design interfaces. EIS was used evaluate effect anodic potential on preparation route for characterization grafted polymers. It also included application as transducing tool antibody-...
Candida glabrata is a second most common human opportunistic pathogen which causes superficial but also life-threatening systemic candidosis. According to the localisation of mannans and mannoproteins in outermost layer cell wall, mannan detection could be one first steps recognition cells by host innate immune system. Mannans from wall provide important immunomodulatory activities, comprising stimulation cytokine production, induction dendritic (DCs) maturation T-cell immunity. The model...
Chitin, a polymer of β-(1→4)-linked N -acetyl-d-glucosamine, is one the main polysaccharide components fungal cell wall. Its N-deacetylated form, chitosan, enzymatically produced in wall by chitin deacetylases. It exerts immunomodulative, anti-inflammatory, anti-cancer, anti-bacterial, and anti-fungal activities with various medical applications. To study immunobiological properties chitosan oligosaccharides, we synthesized series -acetyl-d-glucosamine oligomers comprising 3, 5, 7...
Abstract Background The need to limit antibiotic therapy due the spreading resistance of pathogenic microorganisms these medicinal substances stimulates research on new therapeutic agents, including treatment and prevention animal diseases. This is one goals European Green Deal Farm-To-Fork strategy. Yeast biomass with an appropriate composition exposure cell wall polysaccharides could constitute a functional feed additive in precision nutrition, naturally stimulating immune system fight...
Yeast mannoproteins are proposed as a paraprobiotics with antimicrobial and prebiotic properties. They can be used biopreservatives in food diseases therapies. The knowledge about the specificity and/or capability of their influence on growth different microorganism is limited. study determined effect mannoprotein preparations Saccharomyces cerevisiae (S. cerevisiae) ATCC 7090 nonconventional yeast origin [Metschnikowia reukaufii (M. reukaufii) WLP 4650 Wickerhamomyces anomalus (W. anomalus)...
The incidence and prevalence of serious fungal infections is rising, especially in immunosuppressed individuals. Moreover, co-administration antibiotics immunosuppressants has driven the emergence new multidrug-resistant pathogens. significant increase pathogens, together with their ability to form biofilms, associated morbidity mortality. Research on novel synthetically prepared immunomodulators as potential antifungal immunotherapeutics interest. Our study demonstrated immunobiological...
The effects of 6-amino-2-n-pentylthiobenzothiazole (APB), a new antifungal agent, on ergosterol biosynthesis in Candida albicans and Saccharomyces cerevisiae were studied, using [14C]acetate incorporation. In C. albicans, the inhibition growth was accompanied by marked acetate incorporation 4-desmethylsterols, with significant portion radiolabel being incorporated 4,4-dimethylsterols, lanosterol, 4,4-dimethylzymosterol minor amounts 4-methylsterols squalene. data are interpreted as evidence...
A method for the determination of acrylamide traces as a residue anti-incrustation agents in sugar was developed. Acrylamide extracted into ethyl acetate after derivatization by bromination to 2,3-dibromopropionamide (2,3-DBPA). The extract cleaned up on silica gel column and analysed gas-liquid chromatography with an alkali flame-ionization detector (AFID). glass capillary OV-1 stationary phase used this analysis. recovery determined model experiments 70.0% 77.1% at 100 micrograms kg-1 20...
O135 serotype Vibrio cholerae isolated from Slovak river was used as a source of surface polysaccharide antigens. Following detoxification procedure, fractions polysaccharides were separated by size exclusion chromatography. Two resultant the capsular (M w ∼ 197,000 Da) and lipopolysaccharide fragment 13,300 Da). These materials for preparation four novel glycoconjugates. them containing detoxified antigen prepared original chemical method using new biocompatible polymer carrier antigen....