A5100753318- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Circular RNAs in diseases
- Melanoma and MAPK Pathways
- Ubiquitin and proteasome pathways
- Effects of Radiation Exposure
- Medicinal Plants and Bioactive Compounds
- Cell death mechanisms and regulation
- Signaling Pathways in Disease
- Mechanisms of cancer metastasis
- Cancer-related Molecular Pathways
- Extracellular vesicles in disease
- Prion Diseases and Protein Misfolding
- Antioxidants, Aging, Portulaca oleracea
- Hippo pathway signaling and YAP/TAZ
- Cancer-related molecular mechanisms research
- Trace Elements in Health
- Proteoglycans and glycosaminoglycans research
- Cancer Research and Treatments
- Aldose Reductase and Taurine
- Glycosylation and Glycoproteins Research
- Estrogen and related hormone effects
- Microtubule and mitosis dynamics
- Neurological diseases and metabolism
- Macrophage Migration Inhibitory Factor
China-Japan Friendship Hospital
2024
Fudan University
2023
Zhongshan Hospital
2023
Tongji Hospital
2023
Huazhong University of Science and Technology
2023
Guiyang Medical University
2021
Affiliated Hospital of Guizhou Medical University
2021
Binzhou University
2016-2021
Binzhou Medical University
2016-2021
First Affiliated Hospital of Xi'an Jiaotong University
2016
Estrogen receptors (ERalpha and ERbeta) are ligand-regulated transcription factors that play critical roles in the development progression of breast cancer by regulating target genes involved cellular proliferation. The transcriptional activity ERalpha ERbeta is known to be modulated cofactor proteins. We used a yeast two-hybrid system identified NFAT3 as novel ERbeta-binding protein. interacted with both vitro mammalian cells ligand-independent fashion. bound specifically region containing...
// Lei Zhou 1, 2, 3 , Zhixin Wang 4 Xinsen Xu 2 Yong Wan Kai Qu Haining Fan Qiangpu Chen 1 Xuejun Sun Chang Liu Department of Hepatobiliary Surgery, The Affiliated Hospital Binzhou Medical University, Binzhou, China First Hospital, School Medicine, Xi’an Jiaotong Xi’an, General Hepatopancreatobiliary Qinghai Xining, Correspondence to: Chen, e-mail: drcqp@hotmail.com Sun, sunxj@mail.xjtu.edu.cn Liu, liuchangdoctor@163.com Keywords: Nek7, hepatocellular carcinoma, cell...
Raf kinase inhibitor protein (RKIP) may be a suppressor of metastasis: RKIP levels are high in normal tissues, low primary cancers and lowest or absent metastatic cancers. This immunohisto chemistry study investigated 250 clinical specimens human cervical tissue lymph node metastases (LNM) from 210 patients with tissue, intra-epithelial neoplasia (CIN), cancer with/without LNM. Thirty-nine (86.7%) the 45 normal-tissue samples were RKIP-positive, six (13.3%) RKIP-negative; 48/60 (80.0%) CIN...
Circular RNAs (circRNAs) play key roles in many malignant tumors, including pancreatic cancer (PC); however, whether circular RNA hsa_circ_0006117, a newly identified circRNA, has role PC not been investigated. Here, order to elucidate the and potential molecular mechanisms of circRNAs, we utilized bioinformatic tolls screen differentially expressed circRNAs PC. Subsequently, hsa_circ_0006117 was as being highly tissues two GEO datasets, which further verified cell lines tissues. Then, its...
The transcription factor estrogen receptor β (ERβ) plays roles in the central nervous, endocrine, cardiovascular, and immune systems. ERβ can be SUMOylated. However, underlying mechanism remains unclear. Here, we show that RSRC1/SRrp53 interacts with SUMOylation of RSRC1 is required for regulation PIAS1‐mediated SUMOylation. promotes through enhanced interaction between PIAS1. represses transcriptional activity By establishing as a novel cofactor SUMOylation, our data provide insight into...
Background. Mounting evidence has shown circular RNAs (circRNAs) play an important role in the initiation and progression of pancreatic cancer (PC). Meanwhile, circRNAs may serve as biomarkers for diagnosis, treatment, prognosis PC. Therefore, it is urgent to elucidate function underlying mechanism development Methods. The Cancer-Specific CircRNA Database (CSCD), Circular RNA Interactome database (circinteractome database), reverse transcription-quantitative polymerase chain reaction...
Liver cancer is one of the most common malignancies that difficult to treat due late diagnosis and chemo-resistance. In present study, we developed validated a cell based split nanoLuc biosensor monitor Apaf1-Apaf1 interactions in response apoptosis-inducing drugs such as cisplatin. We showed activity reconstituted only apoptotic inducer, cisplatin dose-dependent manner. Apaf1 mutants which were unable oligomerize failed recover while constitutively active variant increased activity....
Anti-scrapie breeding programs have been initiated to screen for scrapie-resistant sheep based on ovine prion protein gene (PRNP) genotypes at codons 136, 154 and 171 in many countries, especially European Union member states.However, investigation of PRNP is limited China, despite the large number breeds.We analyzed 432 five different breeds from farms northwestern using PCR-single-strand conformational polymorphism analysis (PCR-SSCP); corresponding haplotypes alleles were cloned.PRNP...
Oxidative damage to hair cells is the major cause of ototoxicity induced by cisplatin (cis)-based chemotherapy. In this study, we aimed assess how salidroside (SAL) protected cochlear explants (CEs) and HEI-OC1 cell lines against cis-induced reduced relative hearing loss in mouse models. Furthermore, protective mechanism Nrf2/ARE pathway was investigated. Cell Counting Kit-8 used measure viability cells. Flow cytometry TUNEL assay were evaluate apoptosis. intracellular reactive oxygen...
Objective Investigate the effect of up regulation RKIP (Raf kinase inhibitory protein) gene on biological behavior cervical cancer cell line SiHa. Methods pcDNA3. 1(+ )-RKIP was transfected into SiHa cells by liposome. After stable screening, were divided blank control, empty vector transfected, and group. MTT assay used to detect proliferation, adhesion, invasion abilities in vitro. The cycle changes detected flow cytometry. Results The RT-PCR found that mRNA expressions...