A5100753283- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Nosocomial Infections in ICU
- MicroRNA in disease regulation
- Salivary Gland Tumors Diagnosis and Treatment
- Graphene and Nanomaterials Applications
- Pharmacological Effects of Natural Compounds
- Inhalation and Respiratory Drug Delivery
- Reconstructive Surgery and Microvascular Techniques
- biodegradable polymer synthesis and properties
- Advanced Sensor and Energy Harvesting Materials
- Bone Metabolism and Diseases
- Acne and Rosacea Treatments and Effects
- Bone health and treatments
- Cancer Immunotherapy and Biomarkers
- Mesenchymal stem cell research
- Phytoplasmas and Hemiptera pathogens
- Radiation Dose and Imaging
- Peptidase Inhibition and Analysis
- Angiogenesis and VEGF in Cancer
- Antibiotics Pharmacokinetics and Efficacy
- Ultrasound in Clinical Applications
- RNA modifications and cancer
Second Hospital of Shanxi Medical University
2024
Shanxi Medical University
2024
Zhongshan Hospital of Xiamen University
2024
Tianshui Normal University
2023
Soochow University
2012-2021
Second Affiliated Hospital of Soochow University
2012-2021
Zhejiang University
2012-2013
Pitié-Salpêtrière Hospital
2012-2013
Sorbonne Université
2010-2013
Assistance Publique – Hôpitaux de Paris
2010-2013
Biodegradable synthetic scaffolds hold great promise for oral and craniofacial guided tissue regeneration bone regeneration. To overcome the limitations of current scaffold materials in terms osteogenic antimicrobial properties, we have developed a novel silver-modified/collagen-coated electrospun poly-lactic-co-glycolic acid/polycaprolactone (PLGA/PCL) (PP-pDA-Ag-COL) with improved properties. Our was generated by electrospinning basic PLGA/PCL matrix, followed silver nanoparticles (AgNPs)...
Abstract PD-1 is a co-inhibitory receptor expressed by CD8 + T cells which limits their cytotoxicity. PD-L1 expression on cancer contributes to immune evasion cancers, thus, understanding the mechanisms that regulate protein levels in cancers important. Here we identify tumor-cell-expressed otubain-2 (OTUB2) as negative regulator of antitumor immunity, acting through PD-1/PD-L1 axis various human cancers. Mechanistically, OTUB2 directly interacts with disrupt ubiquitination and degradation...
In experimental pneumonia, nebulization of antibiotics provides high lung tissue concentrations and rapid bacterial killing.To assess the efficacy safety nebulized ceftazidime amikacin in ventilator-associated pneumonia caused by Pseudomonas aeruginosa.Forty patients with aeruginosa were included a randomized comparative phase II trial. Twenty infected susceptible or intermediate strains received (15 mg·kg(-1)·3 h(-1)) (25 mg·kg(-1)·d(-1)). Seventeen intravenous (90 mg·kg(-1)·d(-1),...
Colistin often remains the only active agent against multidrug-resistant Gram-negative pathogens. The aim of study was to assess efficacy nebulized colistin for treating ventilator-associated pneumonia (VAP) caused by Pseudomonas aeruginosa and Acinetobacter baumannii.One hundred sixty-five patients with VAP P. A. baumannii were enrolled in a prospective, observational, comparative study. sensitive strain group included 122 susceptible β-lactams, aminoglycosides, or quinolones treated...
Human umbilical cord mesenchymal stem cells (hUCMSCs) exhibit potent self-renewal and multilineage differentiation characteristics. They have garnered substantial attention within the domain of regenerative medicine owing to their therapeutic potential, such as in tissue repair, regeneration, immunomodulation, anti-inflammation, angiogenesis, wound healing, neuroprotection, neuroregeneration. The process fate determination is initiated by multiple signaling molecules. During development...
To improve bone regeneration in oral microenvironment, we generated a novel biodegradable, antibacterial, and osteoconductive electrospun PLGA/PCL membrane as an ideal osteogenic scaffold. The three-layer membranes were structured with serial layers of chlorhexidine-doped-PLGA/PCL (PPC), (PP), β-tricalcium phosphate-doped-PLGA/PCL (PPβ). characterize properties these membranes, MC3T3-E1 (MC) cultures seeded onto the for 14 days evaluation cell proliferation, morphology gene/protein...
Abstract: Constructing biomimetic structure and incorporating bioactive molecules is an effective strategy to achieve a more favorable cell response. To explore the effect of electrospinning (ES) nanofibrous architecture collagen I (COL I)-incorporated modification on tuning osteoblast response, resorbable membrane composed poly(lactic-co-glycolic acid)/poly(caprolactone) (PLGA/PCL; 7:3 w/w) was developed via ES. COL blended into PLGA/PCL solution prepare composite ES membrane. Notably,...
Lu, Qin*; Luo, Rubin†; Bodin, Liliane*; Yang, Jianxin*; Zahr, Noël*; Aubry, Alexandra‡; Golmard, Jean-Louis*; Rouby, Jean-Jacques* The Nebulized Antibiotics Study Group Author Information
Salivary adenoid cystic carcinoma is one of the most common malignancies head and neck. The lysosome-associated protein transmembrane-4β gene (LAPTM4B) a novel oncogene that has been found overexpressed in number clinically aggressive cancers. This study aimed to investigate expression LAPTM4B-35 normal salivary gland carcinoma, relatively indolent malignancy, explore its clinicopathological significance this malignancy. By immunohistochemical analysis, was evaluated 106 cancer tissues,...
Oral squamous cell carcinoma (OSCC) had the poor prognosis. miR-155 was involved in some diseases. However, whether BMSCs with high expression affect proliferation and metastasis of OSCC is unclear. Our study aims to assess BMSCs’ effect on cells. level tumor tissues analyzed. were transfected followed by analysis MTT assay, apoptosis migration, MMP-9 ELISA PTEN12 level. In tissue, significantly increased ( P <0.05). Co-culture cells could promote reduced apoptotic activity, migration...
Adult female acne is a relatively unique dermatological condition that has been challenging problem in modern medicine due to its complex etiology and tendency recur. Traditional Chinese Medicine clear advantages treating adult acne. My mentor, Yang Jianxin, extensive clinical experience believes the pathogenesis of involves liver stagnation spleen deficiency, with affected organs being spleen. The disease nature combination deficiency excess. Treatment should be based on holistic approach,...
Objective To investigate the effect of deferasirox on DLL4 expression and angiogenesis in a narrow pedicle random flap rats.Methods Twenty SD rats were randomly divided into deferagirox group control group.Rats subjected to 100 mg · kg-1 d-1 inthe experimental groups,respectively same dose saline for 1 week. In each group,flap created bilateral back rats.Ratio length width tissue portion was cm × 3 cm,respectively.The samples taken from middle portions flap.The CD105 also detected with...