A5021411362- Cholesterol and Lipid Metabolism
- Drug Transport and Resistance Mechanisms
- Steroid Chemistry and Biochemistry
- Cyclopropane Reaction Mechanisms
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Asymmetric Synthesis and Catalysis
- Synthesis and Reactivity of Heterocycles
- Herpesvirus Infections and Treatments
- Estrogen and related hormone effects
- Catalytic Alkyne Reactions
- Monoclonal and Polyclonal Antibodies Research
- Peroxisome Proliferator-Activated Receptors
- Natural product bioactivities and synthesis
- Catalytic C–H Functionalization Methods
- HIV Research and Treatment
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Lipid Membrane Structure and Behavior
- Immunotherapy and Immune Responses
- Sphingolipid Metabolism and Signaling
University of Perugia
2020-2024
University College London
2023
The bulk solvent-free synthesis of cyclopropanes via a ball-milling-enabled Simmons–Smith reaction is herein described.
Abstract Lipid and cholesterol metabolism play a crucial role in tumor cell behavior shaping the microenvironment. In particular, enzymatic non-enzymatic metabolism, derived metabolites control dendritic (DC) functions, ultimately impacting antigen presentation within outside mass, dampening immunity immunotherapeutic attempts. The mechanisms accounting for such events remain largely to be defined. Here we perturbed (oxy)sterol genetically pharmacologically analyzed lipidome landscape...
Genital herpes, most frequently caused by herpes simplex virus 2 (HSV-2) infection, is one of the prevalent sexually transmitted infections. The current rationale for treatment HSV-2 infection involves nucleoside analogs (e.g. acyclovir) to suppress reactivation. Enzymatic oxysterols are endogenous 27-carbon atoms molecules produced enzymatic cholesterol oxidation, and recently emerged as a broad-spectrum host targeting antivirals. In this study, we screened selected members an in-house...
A plethora of studies have demonstrated the crucial role played by Liver X Receptors (LXRs) in cancer. However, whether LXRs activation results pro-versus anti-tumor effects is still matter debate. Recently, we reported ability 22(S)-hydroxycholesterol-3-sulfate (PFM037) to antagonize LXRα activity, and, at same time, its capability improve in-vivo immune responses. Herein report first study aimed definition structure-activity relationships PFM037. Successfully, identified...
Steroid chemistry blossomed in the middle of last century, with discovery biological activities main steroid hormones. Today, is still a challenging and stim...