A5006092101- Histone Deacetylase Inhibitors Research
- Click Chemistry and Applications
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- Adenosine and Purinergic Signaling
- Digestive system and related health
- Chemical Synthesis and Analysis
- Cancer, Stress, Anesthesia, and Immune Response
- IL-33, ST2, and ILC Pathways
- TGF-β signaling in diseases
- NF-κB Signaling Pathways
- Synthesis of Tetrazole Derivatives
- Immune cells in cancer
Birla Institute of Technology and Science - Hyderabad Campus
2023-2024
Birla Institute of Technology and Science, Pilani
2023-2024
A series of novel quinazoline-4-(3H)-one derivatives were designed and synthesized as histone deacetylase 6 (HDAC6) inhibitors based on the cap group benzhydroxamic acid linker metal-binding group. total 19 analogues (5a-5s) obtained. The structures target compounds characterized using 1H-NMR, 13C-NMR, LC-MS, elemental analyses. Characterized screened for inhibition against HDAC8 class I, HDAC4 IIa, HDAC6 IIb. Among tested, 5b proved to be most potent selective inhibitor with an IC50 value...
Long-standing chronic inflammation of the digestive tract leads to Inflammatory Bowel Diseases (IBD), comprising Crohn's Disease (CD) and Ulcerative colitis (UC). The persistent prevalence these conditions in gut is a predisposing factor for Colitis-Associated Cancer (CAC), one most common sub-types Colorectal (CRC), emphasizing role tumorigenesis. Therefore, targeted intervention intestinal potential strategy preclusion treatment inflammation-driven malignancies. association between bile...
The intestinal tract encompasses one of the largest mucosal surfaces with a well-structured layer epithelial cells supported by network underlying lamina propria immune maintaining barrier integrity. commensal microflora in this environment is major contributor to such functional outcomes due its prominent role production secondary metabolites. Of several known metabolites gut microbial origin, as Short Chain Fatty Acids (SCFAs), amino acid derivatives, etc., bile acids (BAs) are also shown...
Withanolides are a group of naturally occurring plant-based small molecules known for their wide range host cellular functions. The anticancer potential withanolides has been explored in varying cancer cell lines