A5103267606- Liver Disease Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Pediatric health and respiratory diseases
- Esophageal and GI Pathology
- Metastasis and carcinoma case studies
- Adipose Tissue and Metabolism
- Multiple and Secondary Primary Cancers
- Neonatal Health and Biochemistry
- Pneumocystis jirovecii pneumonia detection and treatment
- Breastfeeding Practices and Influences
- Chronic Lymphocytic Leukemia Research
- Infant Nutrition and Health
- Cancer-related molecular mechanisms research
- Drug Transport and Resistance Mechanisms
- Fungal Biology and Applications
- Cancer, Hypoxia, and Metabolism
- Infectious Encephalopathies and Encephalitis
- Musculoskeletal synovial abnormalities and treatments
- Chronic Myeloid Leukemia Treatments
- Diet, Metabolism, and Disease
- Hematological disorders and diagnostics
- Pediatric Hepatobiliary Diseases and Treatments
- Hemophilia Treatment and Research
- Inflammatory Bowel Disease
- Respiratory viral infections research
Shenzhen Children's Hospital
2015-2025
Institute of Biochemistry and Genetics of Ufa Scientific Centre
2023
Bashkir State Medical University
2023
Republican Oncological Clinical Dispensary
2023
Center for Digestive and Liver Diseases
2022
Anhui Provincial Center for Disease Control and Prevention
2020-2022
University of Pittsburgh Medical Center
2021
East Carolina University
2019
Beijing Tongren Hospital
2019
Capital Medical University
2019
Nonalcoholic fatty liver disease (NAFLD) is a global health threat. Here, we presented the significant role of novel signaling axis comprising long non-coding RNA maternally expressed gene 3 (MEG3), enhancer zeste homolog 2 (EZH2), and sirtuin 6 (SIRT6) in controlling lipid accumulation, inflammation, progression NAFLD. Mice fed with high-fat diet (HFD) were established as vitro vivo NAFLD models, respectively. Lipid accumulation was measured by oil red O staining assays for triglycerides or...
Abstract Background Ulcerative colitis (UC) belongs inflammatory disease with chronic and relapsing characterizations increased-cancer risk. CX5461 has been demonstrated the important roles in autoimmune disease, immunological rejection, macrophage-mediated vascular inflammation. However, whether can serve as UC therapeutic drug remains unclear. The objective of this study is to investigate effect oral administration SFELNVs@CX5461 on DSS-induced its possible molecular mechanism. Methods...
Periodontitis is a chronic inflammatory disease affecting the supporting tissues of teeth and has emerged as global public health issue. Current therapies primarily address pathogenic factors alleviate symptoms, with limited options available for complete restoration reconstruction already absorbed periodontal bone tissue. In this study, we developed nanotherapeutic strategy utilizing fusion nanovesicles (FVs) to modulate microenvironment create regenerative niche ligament stem cells...
Oral squamous cell carcinoma (OSCC) is one of the most common head and neck tumors with high incidence mortality. Long noncoding RNA bladder cancer-associated transcript 1 (lncRNA BLACAT1) was involved in several cancers development. However, roles BLACAT1 OSCC have not been investigated.The expressions miR-142-5p cells were measured by quantitative real-time polymerase chain reaction (qRT-PCR). Cell viability evaluated MTT assay. migration invasion transwell assay assay, respectively. The...
Abstract Ulcerative colitis (UC) belongs to chronic inflammatory disease with a relapsing characterization. Conventional oral drugs of UC are restricted in clinical by premature degradation the gastrointestinal tract, modest efficacy, and adverse effects. CX5461 can treat autoimmune disease, immunological rejection, vascular inflammation. However, low solubility, intravenous administration, non-inflammatory targeting limited its application. Herein, this work aims develop Sophora Flavescens...
We used targeted next-generation sequencing to investigate whether genetic variants of lipid metabolism-related genes are associated with increased susceptibility nonalcoholic fatty liver disease (NAFLD) in obese children.A cohort 100 children aged 6 18 years were divided into NAFLD and non-NAFLD groups subjected hepatic ultrasound, anthropometric, biochemical analyses. evaluated the association by investigating single nucleotide polymorphisms each 36 lipid-metabolism-related genes. The...
Endoscopic balloon dilatation (EBD) has become the first line of therapy for benign esophageal strictures (ESs); however, there are few publications about predictive factors outcomes this treatment.To assess EBD treatment after atresia (EA) repair.Children with anastomotic ES thoracoscopic repair treated by from January 2012 to December 2016 were included. All procedures performed under tracheal intubation and intravenous anesthesia using a three-grade controlled radial expansion...
Bronchiolitis is one of the most severe diseases affecting infants worldwide. An imbalanced oropharynx (OP) microbiota has been reported in hospitalized with bronchiolitis; however, dynamics OP and faeces during therapy remain unexplored. In total, 27 who were bronchiolitis selected for this study, sampling was conducted before after clinical recovery. We also recruited 22 age-matched healthy study. The faecal diversity patients lower than that children. (FM) diseased children significantly...
Both haemophagocytic lymphohistiocytosis and acute necrotizing encephalopathy are life-threatening condition. It presents major diagnostic difficulties, since it may have a diversity in clinical picture with many conditions leading to the same presentation. So is key important understand disorders. We report pediatric case of specific presentation which predominantly featured as childhood. discuss diagnosis differential diagnosis, speculate etiology due hypersensitivity. Haemophagocytic...
To analyze the clinical features and gene mutations in an adolescent patient affected with late-onset multiple aeyl-CoA dehydrogenase deficiency (MADD) severe fatty liver.Potential of ETFDH were detected polymerase chain reaction (PCR) DNA sequencing.The 13-year-and-10-month girl has presented weakness without any other special manifestation. Laboratory tests demonstrated elevation myocardial enzyme levels, total cholesterol, lactic acid abnormal serum free acids. H magnetic resonance...
To analyze the clinical characteristics of severe tsutsugamushi disease, and to improve ability clinicians recognize cases.The data patients with disease from January 1st, 2017 December 31st, 2018 in hospitals Yunnan Province were retrospectively collected by Case Report Form (CRF). The age, gender, symptoms at admission; white blood cell (WBC), eosinophil count (EO), red (RBC), platelet (PLT), hemoglobin (Hb), hematocrit (HCT), albumin (ALB), alanine aminotransferase (ALT), aspartate (AST),...
Liver cancer cells evade immune surveillance and anticancer response through various pathways, including the programmed death-ligand 1 (PD-L1)/programmed death-1 (PD-1) checkpoint axis that exhausts CD8+ T cells. Inhibitors or antibodies of PD-L1/PD-1 signaling are considered promising drugs for immunotherapy exhibit favorable clinical responses. However, adverse effects, tolerance, delivery barriers most patients limit application antibodies. Thus, it is critical to develop a novel strategy...
<title>Abstract</title> <bold>Background: </bold>Therapeutic effect of traditional medicines for nonalcoholic fatty liver disease (NAFLD) is far from satisfactory. Tea has been shown to have efficacy in preventing NAFLD. We hypothesized that tea derived extracellular vesicles (TDEVs) may attenuate <bold>Methods: </bold>Extracellular (EVs) were isolated fresh tea. High Performance Liquid Chromatography (HPLC) was used detect the epigallocatechin-3-gallate (EGCG)in TDEVs. Oleic acid-induced...
Background Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by liver inflammation and damage caused a buildup of fat in the liver. Hepatitis C, hepatitis C virus (HCV), disease that can lead to cirrhosis, cancer, failure. MASH are common causes cirrhosis hepatocellular carcinoma. Several studies have shown hepatic steatosis also histological feature HCV infected patients. However, molecular basis for remains poorly understood. Methods Firstly, differentially expressed...