A5101602351- Congenital Diaphragmatic Hernia Studies
- Retinal Diseases and Treatments
- Hernia repair and management
- Neonatal Respiratory Health Research
- Advanced Glycation End Products research
- Pharmacological Effects and Toxicity Studies
- Surgical Simulation and Training
- Drug Transport and Resistance Mechanisms
- Congenital Anomalies and Fetal Surgery
- Epilepsy research and treatment
- Appendicitis Diagnosis and Management
- Pancreatic function and diabetes
- Microbial metabolism and enzyme function
- Anatomy and Medical Technology
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Surgical Treatments
- Pancreatitis Pathology and Treatment
- Retinal Development and Disorders
- Neutropenia and Cancer Infections
- Porphyrin Metabolism and Disorders
- Kawasaki Disease and Coronary Complications
- Oral health in cancer treatment
- Wnt/β-catenin signaling in development and cancer
- Neuroscience of respiration and sleep
Hokkaido University
1982-2025
National Archives and Records Administration
2025
University of Pittsburgh Medical Center
2022-2024
Juntendo University
2018-2024
University of Pittsburgh
2023-2024
Children's Hospital of Pittsburgh
2022-2024
Okayama University Hospital
2024
Ibaraki Children's Hospital
2021-2022
Seirei Hamamatsu General Hospital
2019
Akita University
2014
Autoantibodies in the serum from a patient with connective tissue disease have been used to define high molecule weight acidic nuclear protein antigen. The antigen tentatively termed Ku, after first two letters of patient's name, has distinct physicochemical properties and immunological specificities that distinguish it previously reported antigens. Ku an apparent 300,000 mol wt as determined by gel filtration sucrose density gradient ultracentrifugation techniques. is destroyed trypsin,...
The aryl hydrocarbon receptor is a member of the nuclear superfamily that associates with molecular chaperone HSP90 in cytoplasm. activation mechanism AhR not yet fully understood. It has been proposed after binding ligands such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 3methylcholanthrene (3-MC), or β-naphthoflavone (β-NF), dissociates from and translocates to nucleus. also hypothesized nucleus forms complex other co-chaperones. There are few reports about direct association...
Abstract Insufficient functional β-cell mass causes diabetes; however, an effective cell replacement therapy for curing diabetes is currently not available. Reprogramming of acinar cells toward insulin-producing would offer abundant and autologous source cells. Our lineage tracing studies along with transcriptomic characterization demonstrate that treatment adult mice a small molecule specifically inhibits kinase activity focal adhesion results in trans-differentiation subset peri-islet into...
Although various risks associated with non-occlusive mesenteric ischemia (NOMI) have been reported, to the best of our knowledge, no report has suggested an association between severe traumatic brain injury (sTBI) and NOMI. We experienced a case NOMI in young woman risk except sTBI. A passerby discovered unresponsive lying on street summoned emergency medical services. The was subsequently transported department by ambulance. patient diagnosed sTBI underwent craniotomy same day. After...
Recent epidemiological studies have shown that patients with age-related macular degeneration (AMD) a considerably higher risk of developing Parkinson's disease (PD) later in life, suggesting possible link between these diseases. However, the common mechanisms two diseases remain obscure, although pathophysiology each has been well investigated. In this study, we sought to explore shared pathological features AMD and PD by focusing on leucine-rich repeat kinase 2 (LRRK2) α-synuclein, both...
Suspension-cultured cells derived from immature embryos of winter wheat (Triticum aestivum L. cv. Chihoku) were used in experiments designed to obtain clues the mechanism ABA-induced development freezing tolerance. Cultured treated with 50 μM ABA for 5 d at 23°C acquired maximum level tolerance (LT50; -21.6°C). The increased ABA-treated was closely associated remarkable accumulation 19-kDa polypeptides plasma membrane. polypeptide components isolated by preparative gel electrophoresis and...
Purpose/Aim of the study: To explore possible role vascular adhesion protein-1 (VAP-1) via its enzymatic function as a semicarbazide-sensitive amine oxidase (SSAO) in pathogenesis proliferative diabetic retinopathy (PDR).Materials and Methods: The levels soluble VAP-1/SSAO unsaturated aldehyde acrolein (ACR)-conjugated protein, Nε-(3-formyl-3, 4-dehydropiperidino) lysine adduct (FDP-Lys), were measured vitreous fluid samples PDR non-diabetic patients using ELISA. Recombinant human...
Purpose: To determine the presence of Nε-(3-formyl-3,4-dehydropiperidino) lysine adduct (FDP-Lys), unsaturated aldehyde acrolein-derived lipoxidation end-product, in fibrovascular tissues obtained from patients with proliferative diabetic retinopathy (PDR).Methods: Fibrovascular were collected 11 eyes PDR and paraffin-embedded tissue sections prepared. Tissue localization FDP-Lys was studied by immunohistochemistry. Signal intensity quantified two masked evaluators graded into three discrete...
Brentuximab vedotin (BV), a conjugate of anti-CD30 antibody and monomethyl auristatin E, has emerged as promising treatment option for refractory CD30+ mycosis fungoides (MF) primary cutaneous anaplastic large-cell lymphoma (pcALCL). BV been shown to be safe effective in treating Hodgkin's peripheral T-cell lymphoma. This multicenter, prospective, single-arm phase I/II study evaluated the efficacy Japanese patients with lymphomas, namely Participants were divided into two groups: those MF or...
Objective We attempted to clarify the influence of polymorphisms nuclear receptors on carbamazepine therapy. Participants and methods The common – a tentative pregnane X receptor (PXR)*1B, hepatocyte factor 4α (HNF4α) rs2071197 (c.115+308G>A), cytochrome P450 3A5*3 were genotyped in 168 Japanese patients with epilepsy. associations these disposition, clinical efficacy, incidence adverse effects treatment retrospectively investigated 104 treated alone. disposition also assessed 64 other...
Purpose: To investigate the effect of unsaturated aldehyde acrolein on retinal glial cell migration. Methods: Müller markers expression in TR-MUL5 were confirmed by RT-PCR and immunostaining. Cell viability migration rate cells assessed after stimulation with acrolein. DNA microarray analysis was performed to analyze changes levels migration-related genes stimulated Real-time PCR ELISA validate results. Inhibitors C-X-C motif chemokine ligand 1 (CXCL1), one highly upregulated exposure...
Abstract Chronic pancreatitis is a debilitating disease affecting millions worldwide. These patients suffer from bouts of severe pain that are minimally relieved by medications and may necessitate major surgeries with high morbidity mortality. Previously, we demonstrated “chemical pancreatectomy,” pancreatic intraductal infusion dilute acetic acid solution, ablated the exocrine pancreas while preserving endocrine pancreas. Notably, chemical pancreatectomy resolved chronic inflammation,...
The goal of pharmacogenetics is to deliver safe and effective drug therapy. Genetic polymorphisms in cytochrome P450 (CYP) enzyme genes are implicated the inter-individual variability pharmacokinetics anti-epileptic drugs (AEDs). However, clinical impact CYP on AED therapy remains controversial. Previous studies have shown that defective CYP2C9 alleles affect required dose phenytoin risk its toxicity. We reported CYP2C19-deficient genotype associated with serum concentration an active...
Objective: Acrolein is a highly reactive aldehyde that covalently binds to cellular macromolecules and subsequently modulates function. Our previous study demonstrated acrolein induces glial cell migration, pathological hallmark of diabetic retinopathy; however, the detailed mechanism remains unclear. The purpose this was investigate role in retinal migration by focusing on rho-associated coiled-coil-containing protein kinases (ROCKs). Methods: Immunofluorescence staining for ROCK isoforms...
Aim: To report the value of adult cadavers for training in minimally invasive surgical (MIS) techniques pediatric surgery (PS). Materials and Methods: Three teams, each consisting a board-certified consultant surgeon (CS), senior trainee (ST), junior (JT), attended cadaver (CST) course involving five procedures: thoracoscopic esophagoesophagostomy (TEE), right lower lobectomy (TRL), laparoscopic fundoplication (LFN), hepaticoduodenostomy (LHD), ureteroureterostomy (LUU). The same teams also...
The effectiveness of sildenafil in the management pulmonary hypertension congenital diaphragmatic hernia (CDH) has been reported but not systematically evaluated. Our studies have also demonstrated that intra-amniotic (IA) administration improves CDH.We evaluated pharmacokinetics after IA pregnant rabbits. Following maternal laparotomy, fetuses received injection 0.8 mg sildenafil. Maternal blood, amniotic fluid, and fetal tissues were collected at various time points. concentrations its...
Abstract Background The management of large abdominal wall defects, such as omphalocele or gastroschisis, remains a challenge for pediatric surgeons. Though several techniques have been described to repair those conditions, there is no procedure considered be the standard worldwide. We report an infant girl with giant ventral hernia after staged surgery in whom delayed closure defect was performed successfully using “endoscopic component separation technique (ECST)” without serious...