A5017268140- Global Maternal and Child Health
- HIV/AIDS Research and Interventions
- Malaria Research and Control
- Health disparities and outcomes
- Drug Transport and Resistance Mechanisms
- HIV Research and Treatment
- Antibiotic Resistance in Bacteria
- Mobile Health and mHealth Applications
- Child Nutrition and Water Access
- Maternal Mental Health During Pregnancy and Postpartum
- vaccines and immunoinformatics approaches
- Breastfeeding Practices and Influences
- HIV/AIDS drug development and treatment
- Adolescent Sexual and Reproductive Health
Kenya Medical Research Institute
2021-2024
University of Nairobi
2024
Wellcome Trust
2024
For uncomplicated Plasmodium falciparum malaria, highly efficacious single-dose treatments are expected to increase compliance and improve treatment outcomes, thereby may slow the development of resistance. The efficacy safety a combination artefenomel (800 mg) plus ferroquine (400/600/900/1200 mg doses) for P. malaria were evaluated in Africa (focusing on children ≤ 5 years) Asia.The study was randomized, double-blind, single-dose, multi-arm clinical trial patients aged > 6 months < 70...
Abstract Background The contribution of artefenomel to the clinical and parasiticidal activity ferroquine in combination uncomplicated Plasmodium falciparum malaria was investigated. Methods This Phase 2a, randomized, open-label, parallel-group study conducted from 11th September 2018 6th November 2019 across seven centres Benin, Burkina Faso, Gabon, Kenya, Uganda. Patients aged ≥ 14–69 years with microscopically confirmed infection (≥ 3000 ≤ 50,000 parasites/µL blood) were randomized...
Background: The world needs an effective HIV-1/AIDS vaccine. Even in the broader context of antiretroviral treatment and prevention, a vaccine remains best solution likely key component any package truly ending AIDS epidemic. Vaccine is particularly needed most affected regions like sub-Saharan Africa, where HIV-1 significantly impacts people's lives economy.Methods: CD8+ killer T cells impose selective pressure on their protective potential should be utilized for vaccination. Our program...
The MNH eCohort was developed to fill gaps in maternal and newborn health (MNH) care quality measurement. In this paper, we describe the survey development process, recruitment strategy, data collection procedures, content plans for analysis of generated by study. We also compare that existing multi-country tools on quality. is a longitudinal mixed-mode (in-person phone) will recruit women facilities at their first antenatal (ANC) visit. Women be followed via phone until 10-12 weeks...
Background Antenatal care (ANC) is an essential platform to improve maternal and newborn health (MNH). While several articles have described the content of ANC in low- middle-income countries (LMICs), few investigated quality detection management pregnancy risk factors during ANC. It remains unclear whether women with receive targeted additional Methods findings This observational study uses baseline data from MNH eCohort conducted 8 sites Ethiopia, India, Kenya, South Africa April 2023...
<h3>ABSTRACT</h3> <h3>Background:</h3> The maternal and newborn health (MNH) eCohort is a new mixed-mode (in-person phone) longitudinal survey aiming to provide data on novel undermeasured dimensions of quality along the MNH continuum care. We describe implementation experiences lessons learned in Ethiopia, India, Kenya, South Africa inform future mobile phone-based studies system quality. <h3>Methods:</h3> To document approach lesson learned, we engaged numerous stakeholders conducted...
In Kenya, adolescents spend much of their formative years in boarding secondary schools, which presents a challenging environment for antiretroviral (ART) adherence support among living with HIV (ALHIV). We examined the experiences ALHIV, caregivers adolescents, and school nurses regarding navigating ART schools. Between July November 2022, we conducted focus group discussions (FGDs) ALHIV attending schools Nairobi, in-depth interviews (IDIs) nurses. Clinic records were used to identify...