A5001286621- Diet and metabolism studies
- Gut microbiota and health
- Digestive system and related health
- Hormonal Regulation and Hypertension
- Congenital heart defects research
- Acute Myocardial Infarction Research
- Liver Disease Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Long-Term Effects of COVID-19
- Biochemical effects in animals
- Heart Rate Variability and Autonomic Control
- Clostridium difficile and Clostridium perfringens research
- Cardiac Fibrosis and Remodeling
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Diet, Metabolism, and Disease
- Cardiac Health and Mental Health
- Alcoholism and Thiamine Deficiency
- Fatty Acid Research and Health
- Apelin-related biomedical research
- Lipoproteins and Cardiovascular Health
- Dialysis and Renal Disease Management
- Cardiovascular Function and Risk Factors
- Lymphoma Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
S. M. Kirov Military Medical Academy
2013-2024
Eastbridge Hospital
2017
Orenburg State Medical Academy
2008
The presented clinical practice guidelines of the Gastroenterological Scientific Society Russia (GSSR), diagnostic, and therapeutic approaches for patients with digestive diseases during COVID-19 pandemic. were approved by XXIII Congress GSSR 22nd International Slavonic-Baltic Forum “St. Petersburg — Gastro-2020 ON-LINE” (St. Petersburg, June 11, 2020).
Aim To study the interrelationship between intensity of chronic systemic inflammation (CSI) with severity condition and intestinal microbiocenosis parameters in patients heart failure (CHF). Material methods 47 hospitalized symptomatic CHF were evaluated. The following determined: clinical condition; N-terminal pro-B-type natriuretic peptide (NT-proBNP). C-reactive protein (CRP); serum interleukins (IL) 6 10; composition by mass-spectrometry microbial markers whole blood. Microbiocenosis...
The gut microbiota plays a fundamental role in maintaining normal organism homeostasis, regulating wide range of metabolic, biosynthetic, and immune functions. This complex ecosystem, together with cellular, stromal components the intestinal wall, forms microbial-tissue complex, which pathology is considered universal mechanism for development many diseases, including chronic kidney disease. Accumulation nitrogen metabolism products intestine, specific diet, polypharmacy, sedentary...
The presented clinical practice guidelines of the Gastroenterological Scientific Society Russia (GSSR), diagnostic, and therapeutic approaches for patients with digestive diseases during COVID-19 pandemic. were approved by XXIII Congress GSSR 22nd International Slavonic-Baltic Scientifi c Forum “St. Petersburg - Gastro-2020 ON-LINE” (St. Petersburg, June 11, 2020). Russian Medical Internal Medicine (RSMSIM) recommendations at XV National Medicine, NOGR on basis 1st edition, adopted Slavic-...
The aim of the study was to examine reorganization extracellular matrix left ventricular myocardium (LVM) rats (n = 38) with experimental heart failure (EHF) as affected by perindopril and melatonin administration. Rats LVM studied using methods light microscopy, immunocytochemistry morphometry. At day 14 EHF, marked mosaic staining cardiomyocytes acid dyes, manifest hemodynamic disturbances: venous capillary congestion, lymphostasis, perivascular interstitial edema, there a increase volume...
А im: to analyze the significance of microbial-derived uremic toxins (MDUT) in pathogenesis comorbidities patients with chronic kidney disease (CKD). Key findings. Increased excretion nitrogen metabolism products into intestines CKD is associated dysbiosis; changes metabolic activity gut microbiota and leaky syndrome; which largely cause accumulation MDUT internal environment body: indoxyl sulfate; p-cresyl trimethylamine-N-oxide; etc. The results recent studies allow consider these...
Today, constipation is one of the most important medical and social problems world health. Its prevalence, according to various estimates, exceeds 30%. There no doubt that this pathology precedes occurrence a number diseases not only gastrointestinal tract. For example, studies conducted at La Trobe University in Australia have shown link between chronic development cardiovascular diseases. In management patient suffering from constipation, addition knowledge about regulation intestinal...
Antigenic and metabolic integration of the intestinal microbiota into homeostasis human body is a factor that claims to play key role in pathogenesis cardiovascular diseases. It acquires special significance against background decrease blood circulation congestion digestive system during chronic heart failure. Aim review analysis synthesis studies results on microbiocenosis remodeling The search for articles was conducted databases eLIBRARY.RU Medline terms "gut (microbiome,...
Aim of the study. A study role cardiac telocytes (Tc) in myocardial remodeling and effect changes their morphology on clinical outcome coronary bypass (CABG) patients with chronic heart failure (CHF). Materials methods. The perioperative period was analyzed 83 (43 men 40 women) CHF I, IIA IIB, NYHA functional class I-III undergoing CABG. Myocardial biopsy right atrial appendage (RAA), obtained during CABG, studied using histological, immuno-histochemical (expression CD-34/vimentin, MMP-2,...
Severe natural and climatic conditions, special features of work, rest, nutrition, physical activity communication people in the Arctic zone can seriously affect intestinal microbiota. This review summarizes research results indicating decrease number, changes morphological biological properties lacto-and bifidobacteria, activation opportunistic pathogenic flora inhabitants Far North. Mechanisms a complex interplay between human body microbiocenosis are presentd The influence microbiota on...
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The role of gut microbiota in maintaining homeostasis and development pathophysiological disorders has been actively studied over the past decades. With advent genome sequencing technology, new opportunities are opening up this area. technology sequencing, During statistical processing, there is a need to perform correlation analysis. However, with large number indicators, visual presentation data can be difficult. Heat maps allow you graphically represent amount data. article contains...
Eurasian clinical practice guidelines for dietary management of cardiovascular diseases include actual healthy diet recommendations and modern approaches prevention treatment diseases. Nutritional assessment interventions based on pathogenesis atherosclerosis are presented. Modern nutritional patients with arterial hypertension, coronary heart disease, chronic failure, rhythm disorders, dyslipidemia gout summarized in present recommendations. Particular attention is paid to the obesity...
Aim. To assess the dynamics of levels eicosapentaenoic (EPA), docosahexaenoic (DHA), arachidonic (AA) and linoleic (LA) fatty acids (FA), omega-3 index, relation omega-3/omega-6 polyunsaturated FA (PUFA) in blood decompensated chronic heart failure (CHF) patients under standard management. Material methods. The values 22 were assessed stable CHF (SCHF, n=12) (DCHF, n=24) after decompensation treatment. index was calculated (relation sum EPA DHA to all FA) AA LA. Results. Values DHA, DCHF...
Atrial fibrillation and ischemic heart disease are the key problems in cardiology. Despite of numerous clinical trials researches underlying molecular biology remains uncertain. often combined. During progression myocardial tissue structure changing which lead to structural electrophysiological remodeling promote atrial fibrillation. It has been shown a crucial role oxidative stress chronic systemic inflammation Myeloperoxidase (MPO) is one marker that located azurophilic granules...
Background: For many decades, women in all age groups have a high risk of mortality and perioperative complications cardiac surgery (CS), with its cause being unclear until now. Preoperative prediction cardiovascular (CVC), based only on the clinical instrumental criteria without taking gender into account, also remains unsuccessful. There is an opinion that structural functional changes myocardium, which exist before operation, could significantly affect patient's condition after surgery....
Aim. To assess the influence of synthetic progesterone — drospirenone, on remodeling left ventricle myocardium (LV) in ovariectomized (OE) female rats under circumstances experimental heart failure (EHF). Material and methods. The study was done 25 Wistar rats, mass 260-300 g. Twenty animals (in 2 months after bilateral ovariectomy) underwent modeling EHF by subcutaneous load 0,1% mesaton solution for 14 days with following swimming to profound exhaustion. Four were removed 14th day EHF....
Aim. To assess gender influence on myocardial remodelling, pharmacotherapy efficacy and complications development in chronic heart failure patients (CHF) post cardiac surgery. Material methods. In the study, 87 included, both genders, with CHF, who had been planned for All underwent standard investigations CHF treatment, as other pathologies. Myocardium specimens from right atrium appendage (RAA) were collected during surgery, investigated general histology, immune histochemistry (expression...
Objective. To assess the significance of melatonin, NT-proBNP and morphological markers myocardial remodeling for predicting risk complications after coronary artery bypass grafting (CABG) in patients with ischemic heart disease chronic failure (CHF). Materials methods. We included this study 83 who underwent CABG period from September 2013 to October 2014. All before standard laboratory instrumental examination. Concentrations melatonin were measured 2 days surgery. The evaluation...
In recent years, in the pathogenesis of metabolic syndrome (MS), great importance has been attached to non-alcoholic fatty liver disease (NAFLD) and violation intestinal microbial-tissue complex. This review summarizes current data on possible pathophysiological mechanisms that link NAFLD, pregnancy, microbiota disorders. The clinical consequences NAFLD influence pregnancy development obstetric complications adverse perinatal outcomes are analyzed.
Nutrition occupies one of the important places in programs prevention and non-drug therapy CHF associated diseases. At same time, validity dietary recommendations to patients regarding salt intake, habits use individual nutraceuticals is questionable. The purpose this review present up-to-date data clinical experimental studies concerning sodium restriction, various diets, nutraceuticals, means for correcting intestinal dysbiosis CHF. Materials methods : articles are searched databases...
This study was done in order to establish an expression pattern of the melatonin MT2 receptors (MT2R) LV cardiac myocytes (CM) female rats with hypoestrogenism and heart failure. Hypoestrogenism (hypo‐E) induced by bilateral ovariectomy failure (HF) caused s.c. injection a 1% mezaton solution (0.1ml) followed intensive swimming regimen for 14 days. Thirty adult outbred were used: 10 combination hypo‐E HF (hypo‐E/HF); only; 5 intact served as control. At end experiment, MT2R immunoreactivity...
The review presents modern ideas about the pathophysiology of anemia syndrome associated with celiac disease. Brief information is provided main proteins involved in iron metabolism and their role maintaining homeostasis. Attention paid to multifactorial pathogenetic mechanisms disease, state duodenal mucosa ultrastructural changes villi enterocytes signs atrophy, which play a key regulation absorption, also provides on development functional deficiency its pathogenesis chronic diseases.