A5057508796- Glioma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Brain Metastases and Treatment
- Advanced Neuroimaging Techniques and Applications
- Multiple Sclerosis Research Studies
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Alzheimer's disease research and treatments
- Cancer, Hypoxia, and Metabolism
- Brain Tumor Detection and Classification
- Dementia and Cognitive Impairment Research
- Radiomics and Machine Learning in Medical Imaging
- Fetal and Pediatric Neurological Disorders
- Bone Tumor Diagnosis and Treatments
- Medical Imaging Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Traumatic Brain Injury and Neurovascular Disturbances
- Long-Term Effects of COVID-19
- Advanced Neural Network Applications
- Bone and Joint Diseases
- Spine and Intervertebral Disc Pathology
- Cerebral Venous Sinus Thrombosis
- Acute Ischemic Stroke Management
- MRI in cancer diagnosis
- COVID-19 and healthcare impacts
Universitair Ziekenhuis Brussel
2010-2024
Vrije Universiteit Brussel
2013-2024
Mathys (Netherlands)
2024
Geneeskundige en Gezondheidsdienst
2020
Huisarts en Wetenschap
2016
Université Libre de Bruxelles
2013
Decreased cerebral blood flow (CBF) may contribute to the pathology of multiple sclerosis (MS), but underlying mechanism is unknown. We investigated whether potent vasoconstrictor endothelin-1 (ET-1) involved. found that, compared with controls, plasma ET-1 levels in patients MS were significantly elevated drawn from internal jugular vein and a peripheral vein. The vein/peripheral ratio was 1.4 vs. 1.1 control subjects, suggesting MS, released brain circulation. Next, we performed...
Background Patients with recurrent glioblastoma (rGB) have a poor prognosis median overall survival (OS) of 30–39 weeks in prospective clinical trials. Intravenous administration programmed cell death protein 1 and cytotoxic T-lymphocyte-associated antigen 4 inhibitors has low activity patients rGB. In this phase I trial, intracerebral (IC) ipilimumab (IPI) nivolumab (NIVO) combination intravenous NIVO was investigated. Methods Within 24 hours following the fixed dose (10 mg) NIVO, underwent...
Background No treatment demonstrated to improve survival in patients with recurrent glioblastoma (rGB) a randomized trial. Combining axitinib the programmed cell death ligand 1 blocking monoclonal antibody avelumab may result synergistic activity against rGB. Methods Adult rGB following prior surgery, radiation therapy and temozolomide chemotherapy were stratified according their baseline use of corticosteroids. Patients daily dose ≤8 mg methylprednisolone (or equivalent) initiated (5 oral...
Diffusion weighted imaging sequences are now widely available on Magnetic Resonance Imaging (MRI) scanners. Tensor (DTI) of the brain is able to show white matter tracts and commonly used in human medicine study anatomy, tumors, structural pathways,… The purpose this was interest DTI reveal fibers dogs' brain. MR Images for were obtained with a 3 T system 4 dogs euthanized other reasons than neurological disorders. Combined fractional anisotropic (FA) directional maps first 2 hours after...
Patients with hereditary tumor syndromes undergo periodical magnetic resonance imaging (MRI) screening Gadolinium contrast. accumulation has recently been described in the central nervous system after repeated administrations. The prevalence and rate of different subgroups patients are unknown. Neither mechanism nor clinical impact. This may cause uncertainty about screening. To explore subgroups, we retrospectively analyzed MRIs von Hippel-Lindau disease (VHL) Tuberous Sclerosis Complex...
Magnetic Resonance Imaging (MRI) has become part of the clinical routine for diagnosing neurodegenerative disorders. Since acquisitions are performed at multiple centers using imaging systems, detailed analysis brain volumetry differences between MRI systems and scan-rescan can provide valuable information to correct different scanner effects in multi-center longitudinal studies. To this end, five healthy controls patients belonging various stages AD continuum underwent on three (Philips...
Focal radiation necrosis of the brain (fRNB) is a late adverse event that can occur following treatment benign or malignant lesions with stereotactic therapy (SRT) radiosurgery (SRS). Recent studies have shown incidence fRNB higher in cancer patients who received immune checkpoint inhibitors. The use bevacizumab (BEV), monoclonal antibody targets vascular endothelial growth factor (VEGF), an effective for when given at dose 5–7.5 mg/kg every two weeks. In this single-center retrospective...
Abstract Background Recurrent high-grade glioma (rHGG) lacks effective life-prolonging treatments and the efficacy of systemic PD-1 CTLA-4 immune checkpoint inhibitors is limited. The multi-cohort Glitipni phase I trial investigates safety feasibility intraoperative intracerebral (iCer) postoperative intracavitary (iCav) nivolumab (NIVO) ± ipilimumab (IPI) treatment following maximal safe resection (MSR) in rHGG. Materials methods Patients received 10 mg IV NIVO within 24 h before surgery,...
Background: Magnetic resonance imaging (MRI) acquisition/processing techniques assess brain volumes to explore neurodegeneration in Alzheimer's disease (AD).Objective: We examined the clinical utility of MSmetrix and investigated if automated MRI could discriminate between groups covering AD continuum be used as a predictor for progression.Methods: The Belgian Dementia Council initiated retrospective, multi-center study analyzed whole (WB), grey matter (GM), white (WM), cerebrospinal fluid...
Background Spleen volume reduction followed by re-expansion has been described in acute ischemic stroke both animal and human studies. Splenic contraction might be partially due to sympathetic hyperactivity accompanied release of splenocytes the peripheral circulation, leading immunodepression. Aims To investigate whether spleen changes first week after are associated with post-stroke infections, lymphocytes count autonomic dysfunction. Methods In patients stroke, sizes were calculated from...
Magnetic resonance imaging (MRI) has become important in the diagnostic work-up of neurodegenerative diseases. icobrain dm, a CE-labeled and FDA-cleared automated brain volumetry software, shown potential differentiating cognitively healthy controls (HC) from Alzheimer's disease (AD) dementia (ADD) patients selected research cohorts.This study examines value dm for AD routine clinical practice, including comparison to widely used FreeSurfer investigates if combined volumes contribute...
Multiple sclerosis (MS) is a chronic inflammatory demyelinating and degenerative disorder of the central nervous system. Accelerated brain volume loss (BVL) has emerged as promising magnetic resonance imaging marker (MRI) neurodegeneration, correlating with present future clinical disability. We have systematically selected MS patients fulfilling 'no evidence disease activity-3' (NEDA-3) criteria under high-efficacy disease-modifying treatment (DMT) from database two Belgian centers. BVL...
The Corpus Callosum (CC) is an important structure connecting the two brain hemispheres. As several neurodegenerative diseases are known to alter its shape, it interesting assess as biomarker. Yet, currently, CC-segmentation often performed manually and consequently error prone time-demanding procedure. In this paper, we present accurate automated method for corpus callosum segmentation based on T1-weighted MRI images. After initial construction of a CC atlas healthy controls, new image...
Von Hippel-Lindau (VHL) disease is an autosomal dominantly inherited tumor syndrome. Affected patients develop central nervous system hemangioblastomas and abdominal tumors, among other lesions. Patients undergo annual clinical screening program including separate magnetic resonance imaging (MRI) of the brain, whole spine abdomen. Consequently, are repeatedly subjected to time-consuming expensive MRI scans, performed with cumulative Gadolinium injections. We report our experience a 35-min...
Introduction Optic nerve and chiasm hemangioblastomas are rare tumors, occurring sporadically or in the context of von Hippel-Lindau (VHL) disease. They have only been portrayed isolated case reports small cohorts. Their natural history therapeutic strategies scarcely described. To better characterize these we retrospectively analyzed an optic hemangioblastoma series 12 VHL patients. By combining our own experience to a review all known cases literature, intended create treatment...
Abstract Purpose Automated glioblastoma segmentation from magnetic resonance imaging is generally performed on a four-modality input, including T1, contrast T2 and FLAIR. We hypothesize that information redundancy present within these image combinations, which can possibly reduce model’s performance. Moreover, for clinical applications, the risk of encountering missing data rises as number required input modalities increases. Therefore, this study aimed to explore relevance influence...
Recently, we published a first anatomical diffusion tensor imaging (DTI) atlas regarding white matter tracts in the canine brain. The purpose of this study was to show significance DTI revelation fibres feline brain (i.e., obtain an images) and descriptively compare these previously obtained fibre images MR Images four cats euthanized for reasons other than neurological disorders were with 3 T system. Combined fractional anisotropic (FA) directional maps within hour after death. An...
2034 Background: Patients (pts) with recurrent glioblastoma (rGB) have a poor prognosis, and no treatment option demonstrated to improve survival in randomized trial. Axitinib (AXI), an oral VEGFR 1-3 inhibitor has single agent activity rGB reduces the need for corticosteroids (CS). Avelumab (AVE) is fully human anti-PD-L1 IgG1 antibody clinical various tumor types. Combination of AXI AVE may outcome pts rGB. Methods: This open-label, dual-strata, single-center phase 2 trial investigated...
2534 Background: Intravenous (IV) administration of ipilimumab (IPI) and nivolumab (NIVO) has low activity in recurrent glioblastoma (rGB). Intratumoral (IT) intracavitary (IC) IPI NIVO is under evaluation the GlITIpNi phase I clinical trial. Methods: Patients (pts) with resectable rGB were recruited to cohorts C1, C2 C4; pts non-resectable C3 (biopsy only). IT (brain tissue lining resection cavity during surgery) (10 mg)(C1), or (5 mg) plus mg)(C2, C4), was followed by IC at escalating...
Abstract Graph-theoretical analysis is a novel tool to understand the organisation of brain. We assessed whether altered graph theoretical parameters, as observed in multiple sclerosis (MS), reflect pathology-induced restructuring brain's functioning or result from reduced signal quality functional MRI (fMRI). In cohort 49 people with MS and matched group 25 healthy subjects (HS), we performed cognitive evaluation acquired fMRI. From fMRI measurement, Pearson correlation-based networks were...
COVID-19 can induce neurological sequelae, negatively affecting the quality of life. Unravelling this illness's impact on structural brain connectivity, white-matter microstructure (WMM), and cognitive performance may help elucidate its implications. This cross-sectional study aimed to investigate differences in these factors between former hospitalised patients (COV) healthy controls. Group connectivity were explored using Welch-two sample t-tests two-sample Mann-Whitney U tests....
Abstract Advanced structural brain imaging techniques, such as diffusion tensor (DTI), have been used to study the relationship between DTI-parameters and cognitive scores in multiple sclerosis (MS). In this study, we assessed function 61 individuals with MS a control group of 35 healthy Symbol Digit Modalities Test, California Verbal Learning Test-II, Brief Visuospatial Memory Test-Revised, Controlled Oral Word Association Stroop-test. We also acquired diffusion-weighted images (b = 1000;...
Background: Accumulating evidence indicates that mitochondrial energy failure is involved in the progressive axonal degeneration multiple sclerosis (MS). In patients with MS, it has been shown both levels of N-acetylaspartate (NAA), which a marker energy, and cerebral blood flow (CBF) are reduced normal appearing white matter (NAWM). The latter likely due to vasoconstrictive action endothelin-1 (ET-1) produced by reactive astrocytes, triggered local proinflammatory cytokines. A preliminary...