A5064633382- Educational Innovations and Challenges
- Viral gastroenteritis research and epidemiology
- Escherichia coli research studies
- Neurotransmitter Receptor Influence on Behavior
- Photoreceptor and optogenetics research
- Neuropeptides and Animal Physiology
- Inflammatory Bowel Disease
- Atrial Fibrillation Management and Outcomes
- Receptor Mechanisms and Signaling
- Diabetes and associated disorders
- Inflammasome and immune disorders
- Biochemical effects in animals
- Adrenal Hormones and Disorders
- Human Health and Disease
- Genetics and Neurodevelopmental Disorders
- Cardiac electrophysiology and arrhythmias
- Microscopic Colitis
- Cardiac pacing and defibrillation studies
- Parkinson's Disease Mechanisms and Treatments
- Liver Diseases and Immunity
- Eosinophilic Esophagitis
- Neuroscience and Neuropharmacology Research
- Immune Response and Inflammation
- Cardiac Arrhythmias and Treatments
- Regulation of Appetite and Obesity
Sechenov University
2020-2025
Tver State Technical University
2022-2023
Central Research Institute of Epidemiology
2021
Federal Penitentiary Service
2020
Ministry of Health of the Russian Federation
2020
Institute of Experimental Medicine
2011-2020
Institute of Cardiology
2019
N. I. Lobachevsky State University of Nizhny Novgorod
2016
Russian Academy of Sciences
2012
Academy of Medical Sciences
2012
Inflammatory bowel diseases (IBD) Crohn's disease (CD) and ulcerative colitis (UC) are a group of idiopathic abnormal conditions with unclear etiology similar clinical courses. In addition to intestinal syndrome, these often associated extraintestinal manifestations, the most common which is involvement peripheral joints axial skeleton. The increase in incidence IBD, especially CD, childhood warrants further study this condition's features, including manifestation: joint (JI) pediatric...
Epilepsy is a neurological disease with different clinical forms and inter-individuals heterogeneity, which may be associated genetic and/or epigenetic polymorphisms of tandem-repeated noncoding DNA. These serve as predictive biomarkers various epilepsy. ACAP3 the protein regulating morphogenesis neurons neuronal migration an integral component important signaling pathways. This study aimed to carry out association analysis length polymorphism DNA methylation UPS29 minisatellite gene in...
Внезапная сердечная смерть (ВСС) — одна из доминирующих причин смертности в современном мире, которая продолжает оставаться серьезной медико-социальной проблемой для системы здравоохранения и общества целом. Текущая риск-стратификация пациентов аспекте первичной профилактики ВСС основана преимущественно на фракции выброса левого желудочка (ФВ ЛЖ), величина которой 35 % менее служит решающим аргументом имплантации кардиовертера-дефибриллятора (ИКД). Вместе с тем исключительно такой подход...
Study Objective: To analyse the activity dynamics of Crohn’s disease (CD) and quality life (QoL) children aged 8–17 years. Design: Open prospective non-randomized comparative study. Materials Methods. The was assessed in 37 healthy 28 with Crohn's (17 boys 11 girls). Disease (Paediatric Activity Index, PCDAI) determined using PedsQL 4.0 Generic Core Scales questionnaire which comprises assessment health activity, child’s attitude, problems interpersonal relations, progress at school....
С помощью ПЦР в режиме реального времени проведен анализ уровня мРНК генов центаурина бета 5 (ACAP3) и цистатина Б (CSTB) лейкоцитах периферической крови у здоровых людей, а также пациентов с симптоматической эпилепсией болезнью Паркинсона (форма ранним дебютом). По сравнению контролем обнаружено повышение гена ACAP3 мужчин женщин (в 2,5- 5-раз соответственно), (примерно 6 раз). Кроме того, наблюдалось снижение CSTB при эпилепсии 3 раза) болезни 2.5 раза). Полученные данные указывают на...
The article raises the problem of low interest students in scientific work. question influence motivation levels engineering on their research activities is considered. Attention paid to potential junior courses' block natural science disciplines as first step a series measures attract research. An anonymous survey three-year technical university was conducted identify motivations for vocational training. analysis results assessment different courses by manifestation motives presented, with...
The prognosis following acute myocardial infarction (MI) has improved considerably in recent decades, essentially due to the development of percutaneous coronary intervention and medical therapy, including administration thrombolytic agents. However, despite these major advances, ventricular fibrillation (VF) or rapid tachycardia (VT) still occur during phase MI 2-8% cases. Post-MI VA is traditionally divided into two types: early occurs within 48 h symptom onset, whereas late over after MI....
Introduction . Detection of somatic mutations in the BRAF gene can be used clinical oncology to clarify diagnosis, select therapy and assess prognosis disease. Pyrosequencing technology makes it possible identify both already known new mutations, as well determine mutant allele ratio sample. The aim study was develop pyrosequencing-based method for detecting 592–601 codons gene. Material Methods nucleotide sequences were obtained using «PyroMark Q24» instrument. sensitivity specificity...
The aim of this work was to identify new genetic markers associated with different forms Parkinson's disease. A frequency occurrence allele variants minisatellite UPS29 localized in intron centaurin p5 gene (CENTB5) evaluated for patients pathology. increase short alleles observed disease patients. This value depended on patient sex and age pathology debut. Statistically significant difference control found only females early (30-50 years old) late ( 60 onset We suppose that might be used as...
The problems of ulcerative colitis (UC) in pediatric practice are the difficulties primary diagnosis, severity course due to greater extent colon lesion and difficulty choosing a drug effect. age patients determines lesions UC children. Thus, older group, especially than 15 years, characterized by high frequency left-sided forms contrast adults. choice therapy children with depends on condition, localization lesion, humoral activity child, as well adherence (compliance) therapy. This example...
The importance of building an educational results monitoring system in the format competences was considered and substantiated. Sources, means approaches to informational contents university quality management through qualimetry were shown. Theoretical grounds implementation methods specified.
This article presents a review and case report of autoimmune polyglandular syndrome type 1 (APS-1) in child with hepatitis (AIH) as first clinical manifestation. The duration the disease was 9 years. signs (jaundice, hepatosplenomegaly, impaired pigment metabolism, cytolysis) high degree activity morphological picture monolobular liver cirrhosis stromal parenchymal were noted at age 2.5 received therapy prednisolone. After one year, symptoms not typical AIH noted: salting food, candidiasis...
We examined 23 patients with paroxysmal form of atrial fibrillation in the presence coronary heart disease and hypertension to study в-adrenergic receptor reactivity tone autonomic nervous system (ANS). The evaluation β-adrenergic cell membranes was performed; sinus rhythm variability determined; sympatheticotonic vagotonic disorders were studied before during treatment sotalol. Using a quantitative biochemical method adrenergic organism, individual sensitivity blocking agent (sotalol)...
The objective of the study was to estimate levels C-reactive protein, serum interleukin 1β, and tumor necrosis factor-α in patients with coronary heart disease (CHD) different forms atrial fibrillation (AF). surveyed a total 113 aged 49.6+2.8 years primary diagnosis artery disease. Data demonstrated link between proinflammatory cytokines number seizures arrhythmias. reliably showed that higher TNF-α IL-1β are associated frequency AF episodes.