A5069547613- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Advanced MRI Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Ischemia and Reperfusion
- S100 Proteins and Annexins
- Thyroid Disorders and Treatments
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Oral and Maxillofacial Pathology
- Neurological disorders and treatments
- Radiation Dose and Imaging
- Cardiac Valve Diseases and Treatments
- Hemodynamic Monitoring and Therapy
- Nitric Oxide and Endothelin Effects
- Thyroid Cancer Diagnosis and Treatment
- Genital Health and Disease
- Oral and gingival health research
- Electrolyte and hormonal disorders
- Lymphatic System and Diseases
Na Homolce Hospital
2015-2024
Charles University
2022
Chulalongkorn University
2016
Comenius University Bratislava
1967-1974
Institute of Normal and Pathological Physiology of the Slovak Academy of Sciences
1974
Slovak Academy of Sciences
1974
Background: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly being used for circulatory support in patients with cardiogenic shock, although the evidence supporting its use this context remains insufficient. The ECMO-CS trial (Extracorporeal Membrane Oxygenation Therapy of Cardiogenic Shock) aimed to compare immediate implementation VA-ECMO versus an initially conservative therapy (allowing downstream VA-ECMO) rapidly deteriorating or severe shock. Methods: This...
Pulsed field ablation (PFA) has a unique safety profile when used to treat atrial fibrillation, largely related its preferentiality for myocardial tissue ablation, in particular, esophageal sparing. A pentaspline catheter was the first such PFA system studied clinically fibrillation ablation; these initial regulatory trials, pulmonary vein isolation and left posterior wall ablation. Since approval Europe, clinical practice, physicians have ablated beyond expanded lesion sets closer proximity...
The aim of this study was to assess the relationship between extracorporeal blood flow (EBF) and left ventricular (LV) performance during venoarterial membrane oxygenation (VA ECMO) therapy.Five swine (body weight 45 kg) underwent VA ECMO implantation under general anesthesia artificial ventilation. Subsequently, acute cardiogenic shock with signs tissue hypoxia induced. Hemodynamic cardiac parameters were then measured at different levels EBF (ranging from 1 5 L/min) using arterial venous...
Transcatheter left atrial appendage closure is an alternative therapy for stroke prevention in fibrillation patients. These procedures are currently guided with transesophageal echocardiography and fluoroscopy most centers. As intracardiac (ICE) commonly used other catheter-based procedures, we sought to determine the safety effectiveness of echocardiography-guided Watchman device.A total 27 patients (11 males, 77.0±8.5 years) receiving under guidance at a single center were investigated....
Despite marked advances in intensive cardiology care, current options for outcome prediction cardiac arrest survivors remain significantly limited. The aim of our study was, therefore, to compare the day-specific association neuron-specific enolase (NSE) with outcomes out-of-hospital (OHCA) treated hypothermia. Eligible patients were OHCA targeted temperature management at 33 °C 24 h using an endovascular device. Blood samples NSE levels measurement drawn on days 1, 2, 3, and 4 after...
AimsDurable isolation of the pulmonary veins (PVs) remains cornerstone treatment for paroxysmal atrial fibrillation (PAF) and is also used in some patients with persistent fibrillation. Visually guided laser ablation (VGLA) has been proven to be safe effective as a (AF). It shown high levels durable PV (PVI), even hands less experienced users. This paper presents long-term clinical outcomes all treated VGLA over course 4 years world's most centre: from early product feasibility work treating...
Introduction Veno-arterial extracorporeal life support (ECLS) is increasingly being used to treat rapidly progressing or severe cardiogenic shock. However, it has been repeatedly shown that increased afterload associated with ECLS significantly diminishes left ventricular (LV) performance. The objective of the present study was compare LV function and coronary flow during standard continuous-flow electrocardiogram (ECG)-synchronized pulsatile in a porcine model Methods Sixteen female swine...
Our aim was to evaluate the potential for safely imaging patients with a new type of implantable cardioverter-defibrillator called subcutaneous (S-ICD) in 1.5 T magnetic resonance (MRI) scanner. With increasing number cardiac devices who are indicated MRI, there is growing need establishing MRI compatibility devices. Patients implanted S-ICD systems underwent one or more types anatomical scans. The programmed off and were monitored throughout procedure. Device function evaluated pre-...
Abstract Background Continuous, reliable evaluation of left ventricular (LV) contractile function in patients with advanced heart failure requiring intensive care remains challenging. Continual monitoring dP/dt max from the arterial line has recently become available hemodynamic monitoring. However, relationship between and LV unclear. This study aimed to determine assessed using echocardiography acute failure. Methods Forty-eight (mean age 70.4 years [65% male]) were recruited. Hemodynamic...
We report our single-centre experience of mid-term to long-term retrieval and reimplantation a tine-based leadless pacemaker [Micra transcatheter pacing system (TPS)]. The TPS is clinically effective alternative transvenous single-chamber ventricular pacemakers. Whereas it currently recommended abandon the at end device life, catheter-based may be favourable in specific scenarios.
Catheter ablation is an effective treatment of scar-related ventricular tachycardia (VT), but the overall complexity procedure has precluded its widespread use. Remote magnetic navigation (RMN) been shown to facilitate cardiac mapping and VT in a retrospective series. STOP-VT first multicenter, prospective, single-arm single-procedure study evaluating RMN-based post-infarction VT.Patients with documented prior MI, whom ICD was implanted either for primary or secondary prevention, were...
Prognostic stratification of cardiac arrest survivors is essential for the selection most appropriate therapeutic strategy. However, accurate early outcome predictions this patient population remain challenging. At present, there a lack data examining prognostic value C-terminal provasopressin (copeptin) in survivors.A group 40 out-of-hospital who were treated with endovascular hypothermia was analyzed. Copeptin levels measured blood samples taken at admission using commercially available...
Despite the urgent need for experimental research in field of acute heart failure and, particularly cardiogenic shock, currently there are only limited options large animal models enabling using devices applied to human subjects. The majority available either associated with an unacceptably high rate mortality or incapable developing sufficient severity failure. objective our was develop a novel model severe shock. Advanced left ventricular dysfunction induced by global myocardial hypoxia...
Lipoprotein-associated phospholipase A2 (Lp-PLA2) probably plays an important role in the development of acute coronary syndrome (ACS); elevated levels Lp-PLA2 are associated with a poorer prognosis patients ischemic heart disease. Alterations during ACS and its relationship to standard biomarkers are, however, unclear.Fifty-one consecutive were enrolled study. All managed early invasive strategy according current guidelines for pharmacotherapy; intensive statin therapy was started all at...
The protective effect of therapeutic hypothermia in cardiac arrest survivors (CAS) has been previously well documented. Animal studies have indicated that attenuation tissue oxidative stress (OS) may be involved the mechanisms lead to beneficial hypothermia. extent OS and nitric oxide (NO) production adult CAS treated with endovascular is, however, unknown. A total 11 patients who experienced out hospital were included present study, all mild using Thermogard XP (Alsius, USA) system. target...
Abstract Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is widely used in the treatment of patients experiencing cardiogenic shock (CS). However, increased VA-ECMO blood flow (EBF) may significantly impair left ventricular (LV) performance. The objective present study was to assess effect on LV function acute CS with concomitant severe aortic stenosis (AS) or mitral regurgitation (MR) a porcine model. Eight female swine (45 kg) underwent implantation under general anaesthesia and...