A5078989159- Sepsis Diagnosis and Treatment
- IgG4-Related and Inflammatory Diseases
- Immune Response and Inflammation
- Soft tissue tumor case studies
- Oral and Maxillofacial Pathology
- Gastrointestinal disorders and treatments
- Nosocomial Infections in ICU
- Bone Tumor Diagnosis and Treatments
- Bacterial Identification and Susceptibility Testing
- Platelet Disorders and Treatments
- Hepatitis B Virus Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Liver Disease and Transplantation
- Abdominal vascular conditions and treatments
- Inflammation biomarkers and pathways
- Heart Failure Treatment and Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiovascular Function and Risk Factors
- Sphingolipid Metabolism and Signaling
- Cancer, Stress, Anesthesia, and Immune Response
- Nausea and vomiting management
- Cystic Fibrosis Research Advances
- Liver Diseases and Immunity
- Pharmacological Effects of Natural Compounds
Na Homolce Hospital
2011-2023
Sepsis is a common and serious health problem whereby improvements in diagnosis are crucial increasing survival rates. To test whether profiling transcription applicable to sepsis diagnosis, we analyzed whole blood using microarray containing probes for 340 genes relevant inflammation. The patient's gene expression pattern was highly homogenous, resulting 69% of differentially expressed genes. With positive predictive value 98%, list 50 compiled, randomly chosen transcripts were confirmed by...
The present study was conducted to assess the value of serum concentration lipopolysaccharide-binding protein (LBP) in patients with systemic inflammatory response syndrome (SIRS), sepsis and septic shock respect its ability differentiate between infectious noninfectious etiologies SIRS predict prognosis.This prospective cohort a multidisciplinary intensive care unit. Sixty-eight patients, admitted consecutively unit who met criteria for SIRS, or were included. Serum LBP measured using an...
Abstract Introduction The aim of this study was to compare the early postoperative kinetics procalcitonin (PCT) and C-reactive protein (CRP) serum levels in patients undergoing orthotopic liver transplantation (OLTx) with different immunosuppressive regimens. Methods PCT CRP concentrations were measured a group 28 OLTx recipients before induction anesthesia, at 4 8 hours following graft reperfusion, daily until day 4. same parameters determined 12 resection without conjunctive therapy....
Summary The objectives of this study were to evaluate patients with aortic abdominal aneurysm (AAA) regard immunoglobulin (Ig)G4-related disease (IgG4-RD). IgG4-RD represents a recently defined condition comprised collection disorders characterized by IgG4 hypergammaglobulinemia, the presence IgG4-positive plasma cells in organs affected fibrotic or sclerotizing changes and typical histopathological features. It was identified as possible cause vasculitis large vessels. Studies have been...
We present a retrospective analysis of patients treated in our Department Clinical Biochemistry, Haematology and Immunology, Na Homolce Hospital, during 1997–2013 for Ormond’s disease. analyse the clinical history, diagnostic approaches, surgical, immunosuppressive therapies their subsequent effect on patients. 28 disease were included. Patients with established activity (26 patients) given treatment, using corticosteroids combination azathioprine. Treatment response was evaluated...
Lipoprotein-associated phospholipase A2 (Lp-PLA2) probably plays an important role in the development of acute coronary syndrome (ACS); elevated levels Lp-PLA2 are associated with a poorer prognosis patients ischemic heart disease. Alterations during ACS and its relationship to standard biomarkers are, however, unclear.Fifty-one consecutive were enrolled study. All managed early invasive strategy according current guidelines for pharmacotherapy; intensive statin therapy was started all at...
A longitudinal study launched in 1994 within the framework of Teplice Programme aimed at comparing respiratory morbidity children born (1994-1998) and living districts (TE) Prachatice (PRA) Czech Republic. Lists all illnesses 960 from birth to 10 years age were obtained paediatric medical records. From 26,471 diagnoses (in ICD-10 codes), 34.7% upper infections (URI, J00-02, J06), 11.3% tonsillitis, 10.2% influenza, 9.4% bronchitis, 8.9% laryngitis/tracheitis (J04), 2.7% otitis media, 0.5%...
Myristic acid was identified as a metabolite with the highest diagnostic sensitivity and specificity in metabolome of patients bacteraemia. Subsequently, its significant decrease observed septic shock not responding to treatment. In our study we have captured myristic serum level kinetics 96 hours following accidental intravenous self-administration eubiotic Hylak forte causing infection-like systemic inflammatory response syndrome (SIRS). To knowledge, this is first time levels presented...
Sepsis (and septic shock) is on of the most common causes death worldwide. Bacteremia often, but not necessarily, occurs in patients, impact true bacteremia a patient’s clinical characteristics and outcome remains unclear. The main aim this study was to compare well-defined cohort 258 patients with without treated intensive care unit (ICU) tertiary center hospital Prague, Czech Republic. As expected, more frequently, present previous antibiotic treatment. A higher proportion observed...
Abdominal aortic aneurysm (AAA) is a serious condition of unclear pathogenesis and progression. Two samples were collected from 48 patients during AAA surgery. One sample was the aneurysm, other proximal neck where tissue did not exhibit any aneurysmal changes. Subsequently, gene expression profiles using microarrays (Illumina) compared in RNA extracted samples. Overall, 2,185 genes found to be upregulated 2,100 downregulated; which 158 had different with FDR<0.05 (False Discovery Rate)...
Abstract: Allogeneic SCT remains the only means of cure for many patients with various malignant disorders as well non‐malignant diseases. Infection together severe aGvHD may result in a significant incidence transplant‐related morbidity and mortality. Current evidence suggests that hSPS represent major immunodominant antigens pathogens therefore might play an important role pathogenesis GvHD. We investigated levels total Ig, IgG IgM isotype antibodies to rh‐hsp60, recombinant Mycobacterium...
Currently, Ormond’s disease is classified among IgG4-associated diseases. Its clinical manifestation varies and characterized by the presence of fibrous retroperitoneal tissue that often affects ureters or abdominal aorta iliac arteries. We present a unique case polycystic form disease, imitating tumour in space. At time diagnosis, was not metabolically active did require immunosuppressive therapy. The mass removed surgically. There has been no exacerbation during last 12 months.