A5019377915- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- Radiomics and Machine Learning in Medical Imaging
- Circular RNAs in diseases
- Diabetes Treatment and Management
- Natural Language Processing Techniques
- Extracellular vesicles in disease
- Gastric Cancer Management and Outcomes
- COVID-19 Clinical Research Studies
- Medical Imaging Techniques and Applications
- Infective Endocarditis Diagnosis and Management
- Breast Cancer Treatment Studies
- Lung Cancer Treatments and Mutations
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- RNA Interference and Gene Delivery
- Cardiac Valve Diseases and Treatments
- Apelin-related biomedical research
University of Thessaly
2020-2024
Pasteur Hellenic Institute
2020-2024
Institut Pasteur
2024
DIANA-miRPath is an online miRNA analysis platform harnessing predicted or experimentally supported interactions towards the exploration of combined effects. In its latest version (v4.0, http://www.microrna.gr/miRPathv4), breaks new ground by introducing capacity to tailor target-based functional engine specific biological and/or experimental contexts. Via a redesigned modular interface with rich interaction, annotation and parameterization options, users can now perform enrichment on Gene...
Abstract TarBase is a reference database dedicated to produce, curate and deliver high quality experimentally-supported microRNA (miRNA) targets on protein-coding transcripts. In its latest version (v9.0, https://dianalab.e-ce.uth.gr/tarbasev9), it pushes the envelope by introducing virally-encoded miRNAs, interactions leading target-directed miRNA degradation (TDMD) events largest collection of miRNA–gene date in plethora experimental settings, tissues cell-types. It catalogues ∼6 million...
Early changes in breast intratumor heterogeneity during neoadjuvant chemotherapy may reflect the tumor's ability to adapt and evade treatment. We investigated combination of precision medicine predictors genomic MRI data towards improved prediction recurrence free survival (RFS).
Abstract Coronavirus disease-2019 (COVID-19) can be asymptomatic or lead to a wide symptom spectrum, including multi-organ damage and death. Here, we explored the potential of microRNAs in delineating patient condition predicting clinical outcome. Plasma microRNA profiling hospitalized COVID-19 patients showed that miR-144-3p was dynamically regulated response COVID-19. Thus, further investigated biomarker measured at admission 179 29 healthy controls recruited three centers. In patients,...
Empagliflozin treatment before acute myocardial infarction mainly targets the endothelial cell transcriptome. and after decreased no reflow microvascular injury, leading to reduced infiltration of inflammatory cells, infarct size, improved cardiac function in mice. In diabetic patients receiving empagliflozin infarction, perfused boundary region, flow-mediated dilation, global longitudinal strain were improved.
microRNAs (miRNAs) are small non-coding RNAs (~22 nts) that considered central post-transcriptional regulators of gene expression and key components in many pathological conditions. Next-Generation Sequencing (NGS) technologies have led to inexpensive, massive data production, revolutionizing every research aspect the fields biology medicine. Particularly, RNA-Seq (sRNA-Seq) enables RNA quantification on a high-throughput scale, providing closer look into profiles these crucial within cell....
Only recently, microRNAs (miRNAs) were found to exist in traceable and distinctive amounts the human circulatory system, bringing forth intriguing possibility of using them as minimally invasive biomarkers. miRNAs are short non-coding RNAs that act potent post-transcriptional regulators gene expression. Extensive studies cancer other disease landscapes investigate protective/pathogenic functions dysregulated miRNAs, well their biomarker potential. A specialized resource amassing...
<title>Abstract</title> Calcific aortic valve stenosis (CAVS), characterized by calcium deposition in the a multiannual process, is associated with high mortality and morbidity. To understand phenomena at its early stages, reliable animal models are needed. Here, we used critically revised high-fat vitamin D2 diet rabbit model to unveil earliest vivo-derived mechanisms linked CAVS progression. We modeled inflammation-calcification temporal pattern seen human disease investigated molecular...
MicroRNAs (miRNA) are short, non-coding molecules (~23nt) that fine-tune mRNA expression at the post-transcriptional level by repressing or cleaving their targets. A single miRNA targets several mRNAs; dysfunctions disrupt biological systems. Unravelling interactome of regulators and is vital for networks. Cancer research one hottest fields, due to its high prevalence financial burden. Despite improvements in prevention therapy, challenges from disease complexity precision medicine limit...
DIANA-miRPath webserver enables the exploration of combined miRNA effects using predicted or experimentally supported interactions. Its latest version (DIANA-miRPath v4.0, http://www.microrna.gr/miRPathv4 ), introduces capacity to tailor its target-based functional analysis engine towards specific biological/experimental contexts. Via a modular interface with rich interaction, annotation and parameterization options, users can perform enrichment on Gene Ontology (GO) terms, KEGG REACTOME...