A5003261788- Metabolomics and Mass Spectrometry Studies
- Pharmacogenetics and Drug Metabolism
- Cancer Treatment and Pharmacology
- Chemotherapy-induced cardiotoxicity and mitigation
- Multiple Myeloma Research and Treatments
- Infective Endocarditis Diagnosis and Management
- Cancer-related cognitive impairment studies
- Spectroscopy and Chemometric Analyses
- Chemotherapy-induced organ toxicity mitigation
- Cardiac Valve Diseases and Treatments
- Blood groups and transfusion
- Erythropoietin and Anemia Treatment
- Adrenal and Paraganglionic Tumors
- Diabetes Treatment and Management
- Hemoglobinopathies and Related Disorders
- Gut microbiota and health
- Mitochondrial Function and Pathology
- Peptidase Inhibition and Analysis
- Vascular Anomalies and Treatments
- Pulmonary Hypertension Research and Treatments
- Cardiac Imaging and Diagnostics
- Tracheal and airway disorders
- Isotope Analysis in Ecology
- Neuropeptides and Animal Physiology
- Hormonal Regulation and Hypertension
National and Kapodistrian University of Athens
2021-2025
Hippocration General Hospital
2023
Carfilzomib is an irreversible proteasome inhibitor indicated for relapsed/refractory multiple myeloma. toxicity includes renal adverse effects (RAEs) of obscure pathobiology. Therefore, we investigated the mechanisms nephrotoxicity developed by Carfilzomib. In a first experimental series, used our previously established in vivo mouse models cardiotoxicity, that incorporated 2 and 4 doses Carfilzomib, to identify whether affects pathways. Hematology biochemical analyses were performed, while...
Background: Carfilzomib (Cfz) is an anti-cancer drug related to cardiorenal adverse events, with cardiovascular and renal complications limiting its clinical use. Despite the important progress concerning discovery of underlying causes Cfz-induced nephrotoxicity, molecular/biochemical background still not well clarified. Furthermore, number metabolomics-based studies nephrotoxicity limited. Methods: A metabolomics UPLC–HRMS–DIA methodology was applied three bio-sample types i.e., plasma,...
Colistin (CMS) is used for the curation of infections caused by multidrug-resistant bacteria. CMS constrained toxicity, particularly in kidney and neuronal cells. The recommended human doses are 2.5-5 mg/kg/day, toxicity linked to higher doses. So far,
<title>Abstract</title> Calcific aortic valve stenosis (CAVS), characterized by calcium deposition in the a multiannual process, is associated with high mortality and morbidity. To understand phenomena at its early stages, reliable animal models are needed. Here, we used critically revised high-fat vitamin D2 diet rabbit model to unveil earliest vivo-derived mechanisms linked CAVS progression. We modeled inflammation-calcification temporal pattern seen human disease investigated molecular...
<h3>Background:</h3> Sjögren's disease (SjD) is a systemic autoimmune disorder that primarily affects the exocrine glands, particularly salivary and lacrimal glands. Recent efforts have exploited serum saliva metabolome analysis to enhance our understanding of pathogenetic mechanisms development novel biomarkers, however these studies are hampered by limited patient numbers, poorly characterized SjD cases, absence proper control groups, lack clinicohistologic associations, variations in...
(1) Carfilzomib (Cfz) is an antineoplastic agent indicated for the treatment of multiple myeloma. However, its beneficial action attenuated by occurrence cardiotoxicity and nephrotoxicity as most common adverse effects. Presently, there well-established knowledge on pathomechanisms related to these side effects; however, research metabolic alterations provoked drug limited. (2) An in vivo simulation Cfz-induced toxicity was developed (i) Cfz-treated (ii) control mice. RP-HRMS-based protocol...
Abstract Introduction Carfilzomib (Cfz), an irreversible proteasome inhibitor, is a first line antineoplastic agent indicated for relapsed/refractory multiple myeloma, with its clinical use being hampered by cardiovascular adverse effects. Hypertension, the most common side effect of Cfz, remaining unknown pathogenicity. Purpose Considering that management Cfz-related hypertension remains unmet need and renal function plays pivotal role in blood pressure regulation we sought to investigate...