A5060651419- Peroxisome Proliferator-Activated Receptors
- Nephrotoxicity and Medicinal Plants
- Histone Deacetylase Inhibitors Research
- Neurofibromatosis and Schwannoma Cases
- Ubiquitin and proteasome pathways
- Ocular Diseases and Behçet’s Syndrome
- Genetic factors in colorectal cancer
- Cancer Treatment and Pharmacology
- Myasthenia Gravis and Thymoma
- Sarcoidosis and Beryllium Toxicity Research
- Axon Guidance and Neuronal Signaling
- Diet and metabolism studies
- Angiogenesis and VEGF in Cancer
- Multiple Myeloma Research and Treatments
- Peptidase Inhibition and Analysis
- Diabetes Treatment and Management
- Chronic Kidney Disease and Diabetes
- Chemotherapy-induced organ toxicity mitigation
- Cancer, Hypoxia, and Metabolism
National and Kapodistrian University of Athens
2021-2023
Histone deacetylases (HDACs) are core epigenetic factors, with pivotal roles in the regulation of various cellular procedures, and their deregulation is a major trait acquisition malignancy properties. In this study we attempt first comprehensive evaluation six class I (HDAC1, HDAC2, HDAC3) II HDACs (HDAC4, HDAC5, HDAC6) expression patterns thymic epithelial tumors (TETs), aim identifying possible association number clinicopathological parameters. Our revealed higher positivity rates levels...
Background: Recent advances demonstrate the role of chromatin regulators, including histone variants and chaperones, in cancer initiation progression. Methods: Histone H3K4me3, variant centromere protein (CENP-A) chaperones Holliday junction recognition (HJURP) as well DAXX expression were examined immunohistochemically 95 thymic epithelial tumor (TET) specimens. Our results compared with profile DAXX, HJURP CENP-A gene profiling interactive analysis (GEPIA2). Results: The lymphocyte-poor...
Ephrin receptors (Ephs) are receptor tyrosine kinases (RTKs) implicated in tissue development and homeostasis, they aberrantly expressed tumors. Here, immunohistochemical Eph type-A -B expression thymic epithelial tumors (TETs) was assessed correlated with clinicopathological parameters. Tissue microarrays from 98 TETs were stained for EphA1, -A2, -A4 -A6, -B1, -B2, -B4 -B6. The relationship between neoplastic lymphoid cell immunoreactivity score (H-score), histopathological parameters...
The absence of efficient inhibitors for diabetic kidney disease (DKD) progression reflects the gaps in our understanding DKD molecular pathogenesis. A comprehensive proteomic analysis was performed on glomeruli and cortex mice with subsequent validation findings human biopsies omics datasets, aiming to better understand underlying biology early development progression. LC-MS/MS employed analyze proteome 2 models: Ins2Akita (early late DKD) db/db (late DKD). abundance detected proteins...
Carfilzomib is an irreversible proteasome inhibitor indicated for relapsed/refractory multiple myeloma. toxicity includes renal adverse effects (RAEs) of obscure pathobiology. Therefore, we investigated the mechanisms nephrotoxicity developed by Carfilzomib. In a first experimental series, used our previously established in vivo mouse models cardiotoxicity, that incorporated 2 and 4 doses Carfilzomib, to identify whether affects pathways. Hematology biochemical analyses were performed, while...
Tubulointerstitial nephritis with uveitis syndrome is a rare, immune-mediated entity, characterized by oculo-renal inflammation. Diagnosis requires the exclusion of all other causes tubulointerstitial (TIN). We present 6 patients clinical, laboratory, and renal biopsy findings denotative syndrome. All our experienced ocular manifestations, defined bilateral photosensitivity, along decline function. In some patients, increased serum creatinine was accompanied non-nephrotic range proteinuria,...
Abstract Background and Aims Tubulointerstitial nephritis with uveitis (TINU) syndrome is a rare, but probably under-diagnosed, immune-mediated clinical entity, characterized by simultaneous renal ocular manifestations Diagnosis requires exclusion of all other causes tubulointerstitial (TIN). We present six patients clinical, laboratory biopsy findings consistent TINU Method Medical records review. All underwent biopsy. Histochemical (pas, masson, silver, Congo-red) immunohistochemical...
ABSTRACT Background The absence of efficient inhibitors for DKD progression reflects the gaps in our understanding molecular pathogenesis. A comprehensive proteomic analysis was performed on glomeruli and kidney cortex diabetic mice with subsequent validation findings human biopsies - omics datasets aiming to better understand underlying biology early development progression. Methods LC–MS/MS employed analyze proteome mouse models: Glomeruli Ins2Akita 2 month 4 old, db/db 6 old. Following...